Article
Cell Biology
Nongthombam Boby, Alyssa Ransom, Barcley T. Pace, Kelsey M. Williams, Christopher Mabee, Arpita Das, Sudesh K. Srivastav, Edith Porter, Bapi Pahar
Summary: Increased production of TGF-beta was observed in intestinal CD3(-)CD20(-)CD68(+) cells from SIV-infected rhesus macaques, which negatively correlated with the frequency of jejunum CD4(+) T cells. Disruption of a negative feedback loop mediated by SMAD7 may enhance TGF-beta production and SMAD-dependent signaling in SIV infection.
Article
Virology
Saori Matsuoka, Takeo Kuwata, Hiroshi Ishii, Tsuyoshi Sekizuka, Makoto Kuroda, Masato Sano, Midori Okazaki, Hiroyuki Yamamoto, Mikiko Shimizu, Shuzo Matsushita, Yohei Seki, Akatsuki Saito, Hiromi Sakawaki, Vanessa M. Hirsch, Tomoyuki Miura, Hirofumi Akari, Tetsuro Matano
Summary: This study found a potent antibody induction associated with germ line BCR/antibody Ig gene polymorphism in rhesus macaques infected with SIV. The results demonstrate that a single nucleotide polymorphism in germ line Ig genes could be a determinant for induction of potent antibodies against virus infection. Germ line BCR/antibody Ig gene polymorphisms may be a factor restricting effective antibody induction or responsiveness to vaccination.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Kevin S. White, Joshua A. Walker, John Wang, Patrick Autissier, Andrew D. Miller, Nadia N. Abuelezan, Rachel Burrack, Qingsheng Li, Woong-Ki Kim, Kenneth C. Williams
Summary: Despite effective antiretroviral therapy, comorbidities such as neurocognitive dysfunction and cardiovascular disease (CVD) remain prevalent among people living with HIV. This study investigates the co-development of cardiac pathology and CNS pathology in SIV-infected rhesus macaques, demonstrating a strong correlation with activated myeloid cells. Similar observations were confirmed in HIV-infected individuals, highlighting the need for adjunctive therapies targeting macrophages.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Bapi Pahar, Wayne Gray, Marissa Fahlberg, Brooke Grasperge, Meredith Hunter, Arpita Das, Christopher Mabee, Pyone Pyone Aye, Faith Schiro, Krystle Hensley, Aneeka Ratnayake, Kelly Goff, Celia LaBranche, Xiaoying Shen, Georgia D. Tomaras, C. Todd DeMarco, David Montefiori, Patricia Kissinger, Preston A. Marx, Vicki Traina-Dorge
Summary: By using a varicella virus-vectored SIV vaccine and protein boosts, this study demonstrated a 37.5% efficacy rate against pathogenic SIV challenge in a rhesus macaque model by generating neutralizing antibodies, binding antibodies, and polyfunctional T-cell responses.
Article
Multidisciplinary Sciences
Jeffy G. Mattathil, Asisa Volz, Olusegun O. Onabajo, Sean Maynard, Sandra L. Bixler, Xiaoying X. Shen, Diego Vargas-Inchaustegui, Marjorie Robert-Guroff, Celia Lebranche, Georgia Tomaras, David Montefiori, Gerd Sutter, Joseph J. Mattapallil
Summary: HIV is a virus that causes immunodeficiency and AIDS, and developing vaccines to prevent infection is crucial. We hypothesized that vaccinating mucosa associated lymphoid tissue (MALT) such as the palatine tonsils could overcome the compartmentalization between mucosal and peripheral immune systems. Our study in rhesus macaques showed that priming with plasmid DNA and boosting with MVA in the tonsil MALT protected against SIVmac251 infection, with 43% remaining uninfected after 9 challenges. Vaccination was associated with reduced viremia and enhanced immune responses. This combination approach could provide protection from mucosal infection with highly pathogenic HIV.
NATURE COMMUNICATIONS
(2023)
Article
Virology
Arpan Acharya, Omalla A. Olwenyi, Michellie Thurman, Kabita Pandey, Brenda M. Morsey, Benjamin Lamberty, Natasha Ferguson, Shannon Callen, Qiu Fang, Shilpa J. Buch, Howard S. Fox, Siddappa N. Byrareddy
Summary: This study established a morphine-dependent simian immunodeficiency virus SIVmac251-infected rhesus macaque model to investigate the impact of opioids on HIV reservoirs. The results suggested that opioids, specifically morphine, play a dual role by reducing CD4(+) T-cell reservoirs in lymphoid tissues while increasing the reservoir size in the central nervous system.
JOURNAL OF VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Sara M. Hendrickson, Archana Thomas, Hans-Peter Raue, Kamm Prongay, Andrew J. Haertel, Nicholas S. Rhoades, Jacob F. Slifka, Lina Gao, Benjamin K. Quintel, Ian J. Amanna, Ilhem Messaoudi, Mark K. Slifka
Summary: In this study, the authors investigate the impact of different Campylobacter vaccination regimens on Campylobacter-associated diarrhea, mortality, and growth kinetics in infant rhesus macaques. They find that vaccination significantly reduces the risk of diarrhea-associated deaths and improves infant growth trajectories.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Dan Liu, Jiaojiao Liu, Tingting Xu, Hongwei Qiao, Yu Qi, Yuxun Gao, Ailixire, Lei Gao, Chunlin Li, Mingrui Xia, Hongjun Li
Summary: Using SIV-infected macaques as a model, this study found brain volume changes at 12 weeks post-infection in various brain regions. Despite early initiation of cART after SIV infection, brain atrophy in macaques was still observed, with signs of potential reversibility. Plasma viral load was associated with subcortical nucleus volume, while CD4(+) T-cell count and CD4(+)/CD8(+) ratio in plasma were linked to widespread cortical volume changes.
Article
Medicine, Research & Experimental
Benjamin D. Varco-Merth, William Brantley, Alejandra Marenco, Derick D. Duell, Devin N. Fachko, Brian Richardson, Kathleen Busman-Sahay, Danica Shao, Walter Flores, Kathleen Engelman, Yoshinori Fukazawa, Scott W. Wong, Rebecca L. Skalsky, Jeremy Smedley, Michael K. Axthelm, Jeffrey D. Lifson, Jacob D. Estes, Paul T. Edlefsen, Louis J. Picker, Cheryl M. A. Cameron, Timothy J. Henrich, Afam A. Okoye
Summary: Inhibiting mTOR can decrease the proliferation of CD4(+)TM cells, but chronic mTOR inhibition alone or in combination with T cell activation is not sufficient to disrupt the stability of the SIV reservoir.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Yongjun Sui, Jianping Li, Roushu Zhang, Sunaina Kiran Prabhu, Hanne Andersen, David Venzon, Anthony Cook, Renita Brown, Elyse Teow, Jason Velasco, Jack Greenhouse, Tammy Putman-Taylor, Tracey-Ann Campbell, Laurent Pessaint, Ian N. Moore, Laurel Lagenaur, Jim Talton, Matthew W. Breed, Josh Kramer, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Mark G. Lewis, Lai-Xi Wang, Jay A. Berzofsky
Summary: Comparing two adjuvanted subunit vaccines in rhesus macaques, the study found that both vaccines were effective in protecting against respiratory SARS-CoV-2 exposure, despite potential differences in mucosal and systemic protective mechanisms. The mucosal vaccine was shown to be safe after multiple doses, efficiently clearing the input virus from the nasal cavity, and may serve as a potent complementary boost to conventional systemic vaccines for overall better protection.
Article
Virology
Widade Ziani, Anya Bauer, Hong Lu, Xiaolei Wang, Xueling Wu, Katharine J. Bar, Hui Li, Dongfang Liu, George M. Shaw, Ronald S. Veazey, Huanbin Xu
Summary: The newly developed SHIV.C.CH848 can establish sustained viremia and viral reservoirs in rhesus macaques with clinical immunodeficiency consequences, providing a valuable SHIV model for HIV research. The findings suggest that this CCR5-tropic, SHIVC strain is valuable for testing responses to HIV vaccines and therapeutics in nonhuman primate models.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Anya Bauer, Emily Lindemuth, Francesco Elia Marino, Ryan F. Krause, Jaimy Joy, Steffen P. Docken, Suvadip Mallick, Kevin M. McCormick, Clinton J. Holt, Ivelin A. Georgiev, Barbara C. Felber, Brandon A. Keele, Ronald C. Veazey, Miles A. Davenport, Hui C. Li, George A. Shaw, Katharine C. Bar
Summary: This study reported the generation of a minimally adapted virus, SHIV.C.CH505.v2, which has enhanced replication fitness and preserved native Env properties. It can be used as a new reagent for nonhuman primate studies of HIV-1 transmission, pathogenesis, and cure.
Article
Neurosciences
Samuel D. Johnson, Howard S. Fox, Shilpa Buch, Siddappa N. Byrareddy
Summary: People living with HIV are at higher risk of opioid misuse due to chronic pain prescriptions and injection drug use. Recent research shows that chronic opioid use in the context of HIV and SIV infection may disrupt the gut-brain axis and lead to dysbiosis. Additional research is needed to further understand the complex interaction between host, opioid abuse, and HIV/SIV infection.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2022)
Article
Virology
Chunxiu Wu, Yizi He, Jin Zhao, Kun Luo, Ziyu Wen, Yudi Zhang, Minchao Li, Yilan Cui, Zijian Liu, Congcong Wang, Zirong Han, Guangye Li, Fengling Feng, Pingchao Li, Ling Chen, Caijun Sun
Summary: The persistence of latently infected cells is a major barrier to HIV-1 eradication, and PD-1 blockade can exacerbate the formation and maintenance of the latent reservoir. However, our study found that PD-1 blockade during therapeutic vaccination resulted in activation of the viral reservoir, rapid viral rebound, accelerated AIDS progression, and death in chronically SIV-infected macaques after treatment interruption.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Margherita Rosati, Mahesh Agarwal, Xintao Hu, Santhi Devasundaram, Dimitris Stellas, Bhabadeb Chowdhury, Jenifer Bear, Robert Burns, Duncan Donohue, Laurent Pessaint, Hanne Andersen, Mark G. Lewis, Evangelos Terpos, Meletios Athanasios Dimopoulos, Alexander Wlodawer, James I. Mullins, David J. Venzon, George N. Pavlakis, Barbara K. Felber
Summary: Both DNA and mRNA vaccines have shown promise in animal models, with DNA vaccines demonstrating protective efficacy and immunogenicity against SARS-CoV-2 in rhesus macaques. DNA vaccine regimens can induce potent antibody and T cell responses, with the co-immunization of protein showing superior effectiveness.
Article
Materials Science, Multidisciplinary
Belen Soriano Cuadrado, Pilar Martinez Viedma, Mari Carmen Lopez Aguayo, Irene Ortega Blazquez, Maria Jose Grande Burgos, Ruben Perez Pulido, Antonio Galvez, Rosario Lucas Lopez
Article
Hematology
Nayoung Kim, Sami Kukkonen, Maria Del Pilar Martinez-Viedma, Sumeet Gupta, Anna Aldovini
Article
Food Science & Technology
Pilar Martinez Viedma, Hikmate Abriouel, Nabil Ben Omar, Rosario Lucas Lopez, Antonio Galvez
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2010)
Article
Food Science & Technology
Pilar Martinez Viedma, Hikmate Abriouel, Nabil Ben Omar, Rosario Lucas Lopez, Antonio Galvez
Article
Biotechnology & Applied Microbiology
Pilar Martinez Viedma, Hikmate Abriouel, Nabil Ben Omar, Rosario Lucas Lopez, Eva Valdivia, Antonio Galvez
Article
Biotechnology & Applied Microbiology
Pilar Martinez Viedma, Hikmate Abriouel, Angel Sobrino Lopez, Nabil Ben Omar, Rosario Lucas Lopez, Eva Valdivia, Olga Martin Belloso, Antonio Galvez
Article
Agriculture, Dairy & Animal Science
A. Sobrino-Lopez, P. Viedma-Martinez, H. Abriouel, E. Valdivia, A. Galvez, O. Martin-Belloso
JOURNAL OF DAIRY SCIENCE
(2009)
Article
Biotechnology & Applied Microbiology
Pilar Martinez Viedma, Hikmate Abriouel, Nabil Ben Omar, Rosario Lucas Lopez, Eva Valdivia, Antonio Galvez
JOURNAL OF FOOD PROTECTION
(2009)
Article
Biotechnology & Applied Microbiology
Pilar Martinez Viedma, Angel Sobrino Lopez, Nabil Ben Omar, Hikmate Abriouel, Rosario Lucas Lopez, Olga Martin Belloso, Antonio Galvez
JOURNAL OF FOOD PROTECTION
(2010)
Article
Food Science & Technology
Pilar Martinez Viedma, Hikmate Abriouel, Nabil Ben Omar, Rosario Lucas Lopez, Antonio Galvez
JOURNAL OF FOOD SCIENCE
(2009)
Article
Food Science & Technology
Pilar Martinez Viedma, Danilo Ercolini, Ilario Ferrocino, Hikmate Abriouel, Nabil Ben Omar, Rosario Lucas Lopez, Antonio Galvez
LWT-FOOD SCIENCE AND TECHNOLOGY
(2010)
Article
Virology
Sami Kukkonen, Maria Del Pilar Martinez-Viedma, Nayoung Kim, Mariana Manrique, Anna Aldovini
Article
Virology
Maria del Pilar Martinez Viedma, Brett E. Pickett
Article
Virology
Maria del Pilar Martinez Viedma, Stephen Panossian, Kennedy Gifford, Kimberly Garcia, Isis Figueroa, Leda Parham, Laise de Moraes, Lillian Nunes Gomes, Tamara Garcia-Salum, Cecilia Perret, Daniela Weiskopf, Gene S. Tan, Antonio Augusto Silva, Viviane Boaventura, Guillermo M. Ruiz-Palacios, Alessandro Sette, Aruna Dharshan De Silva, Rafael A. Medina, Ivette Lorenzana, Kevan M. Akrami, Ricardo Khouri, Daniel Olson, Brett E. Pickett
Summary: Zika virus is a mosquito-borne Flavivirus that may lead to neurological sequelae and induce cross-reactive antibodies. Differential diagnosis of Zika virus infection is challenging, but peptide-based ELISA shows high efficiency and correlation with other tests, making it suitable for antibody detection in diverse regions.