Letter
Immunology
Leon Caly, Ashleigh F. Porter, Joanna Chua, James P. Collet, Julian D. Druce, Michael G. Catton, Sebastian Duchene
Summary: During a mouse plague in early 2021, a farmer from New South Wales, Australia, was diagnosed with locally acquired lymphocytic choriomeningitis virus infection. Whole-genome sequencing revealed a divergent and geographically distinct strain of lymphocytic choriomeningitis virus compared to other published sequences.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Mark J. G. Bakkers, Alex Moon-Walker, Rasmus Herlo, Vesna Brusic, Sarah Hulsey Stubbs, Kathryn M. Hastie, Erica Ollmann Saphire, Tomas L. Kirchhausen, Sean P. J. Whelan
Summary: LCMV is a virus that enters cells by binding to different receptors and causes severe health problems. This study found that LCMV first binds to CD164 before entering cells, providing new targets for therapeutic interventions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Virology
Daniel Grupel, Yaniv Lustig, Tal Brosh-Nissimov
Summary: Lymphocytic choriomeningitis virus (LCMV) is an often-overlooked virus that can have severe consequences. We present the first documented infection by LCMV in Israel, and the epidemiology of LCMV is evolving with the potential for a worldwide endemicity, highlighting the need for increased awareness and testing.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Microbiology
Jamin Liu, Kristeene A. Knopp, Elze Rackaityte, Chung Yu Wang, Matthew T. Laurie, Sara Sunshine, Andreas S. Puschnik, Joseph L. DeRisi
Summary: This study identifies novel host factors associated with Lymphocytic choriomeningitis virus (LCMV) infection of human tissues, highlighting the importance of CD164 in viral entry and suggesting it as a potential therapeutic target for congenital infection.
Article
Immunology
Jonathan Dyal, Shiv Gandhi, Caitlin M. Cossaboom, Austin Leach, Ketan Patel, Marjorie Golden, Joseph Canterino, Marie-Louise Landry, Debi Cannon, Mary Choi, Inna Krapiunaya, John D. Klena, Trevor Shoemaker
Summary: Lymphocytic choriomeningitis virus is an underreported cause of miscarriage and neurologic disease. Surveillance remains challenging due to nonspecific symptomatology, inconsistent case reporting, and difficulties with diagnostic testing.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Yuri Ushijima, Haruka Abe, Takehiro Ozeki, Georgelin N. Ondo, Marien J. V. M. Mbadinga, Rodrigue Bikangui, Chimene Nze-Nkogue, Etienne F. Akomo-Okoue, Ghislain W. E. Ella, Lilian B. M. Koumba, Branly C. B. B. Nso, Rodrigue Mintsa-Nguema, Patrice Makouloutou-Nzassi, Boris K. Makanga, Fred L. M. Nguelet, Vahid R. Zadeh, Shuzo Urata, Armel V. N. Mbouna, Marguerite Massinga-Loembe, Selidji T. Agnandji, Bertrand Lell, Jiro Yasuda
Summary: The study revealed a seroprevalence of 21.5% for LCMV in Gabon, with higher rates in males and adults. Local rodents, shrews, and porcupines around semi-urban areas posed an infection risk.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Peter Pankovics, Arnold Nagy, Zoltan Nyul, Annamaria Juhasz, Karoly Takats, Akos Boros, Gabor Reuter
Summary: This retrospective study aimed to detect lymphocytic choriomeningitis virus (LCMV) RNA in cerebrospinal fluid samples from patients with unknown central nervous system infections in Hungary. Two LCMV cases were identified, belonging to different genetic lineages. This is the first publication of confirmed human LCMV infections in Hungary using molecular methods.
ARCHIVES OF VIROLOGY
(2023)
Review
Medicine, General & Internal
Thomas Ferenc, Mateja Vujica, Anna Mrzljak, Tatjana Vilibic-Cavlek
Summary: This study summarizes the epidemiological, clinical, and diagnostic features of reported patients with congenital LCMV infection. A total of 27 studies with 86 patients were included, and the results showed that 52.73% of the patients were males. Common clinical manifestations included chorioretinitis, hydrocephalus, and psychomotor retardation or developmental delay. The diagnosis was most often confirmed serologically, and computed tomography and/or magnetic resonance imaging revealed ventriculomegaly, periventricular calcifications, and microcephaly. Mothers of congenitally infected infants were often exposed to mice during pregnancy, with flu-like symptoms occurring primarily in the first two trimesters.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Cell Biology
Weldy Bonilla, Nicole Kirchhammer, Anna-Friederike Marx, Sandra M. Kallert, Magdalena A. Krzyzaniak, Min Lu, Stephanie Darbre, Sarah Schmidt, Josipa Raguz, Ursula Berka, Ilena Vincenti, Mindaugas Pauzuolis, Romy Kerber, Sabine Hoepner, Stephan Guenther, Carsten Magnus, Doron Merkler, Klaus K. Orlinger, Alfred Zippelius, Daniel D. Pinschewer
Summary: This study engineered two distantly related arenaviruses for therapeutic cancer vaccination and demonstrated that a prime-boost regimen with these viruses induced tumor-specific CTL responses and eliminated established solid tumors in mice. The findings suggest that combining two genealogically distantly related arenaviruses allows reshuffling of immunodominance hierarchies and breaking self-directed tolerance for effective tumor control.
CELL REPORTS MEDICINE
(2021)
Article
Immunology
Vasilis C. Pliasas, Zach Menne, Virginia Aida, Ji-Hang Yin, Maria C. Naskou, Peter J. Neasham, J. Fletcher North, Dylan Wilson, Katharine A. Horzmann, Joshy Jacob, Ioanna Skountzou, Constantinos S. Kyriakis
Summary: This study evaluated the immunogenicity and efficacy of a novel vaccine against influenza virus infection in a pig model. The results showed that the vaccine induced high levels of anti-NA antibodies and provided protection comparable to a commercial vaccine.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Noopur Bhatnagar, Ki-Hye Kim, Jeeva Subbiah, Sakinah Muhammad-Worsham, Bo Ryoung Park, Rong Liu, Phillip Grovenstein, Bao-Zhong Wang, Sang-Moo Kang
Summary: The study suggests that heterologous prime-boost influenza vaccination strategy is more effective in inducing broader protective immunity compared to repeated vaccination with the same antigen, by increasing strain-specific hemagglutination inhibition titers and high levels of IgG antibodies.
Article
Immunology
Andrew Chak-Yiu Lee, Anna Jinxia Zhang, Can Li, Yanxia Chen, Feifei Liu, Yan Zhao, Hin Chu, Carol Ho-Yan Fong, Pui Wang, Siu-Ying Lau, Kelvin Kai-Wang To, Honglin Chen, Kwok-Yung Yuen
Summary: Intradermal vaccination with DelNS1-LAIV provides potent and long-lasting protection against lethal virus challenge in mice, reducing viral load, epithelial cell death, and inflammatory responses. Activation of antigen-presenting cells and strong immunogenicity suggest that antibody responses play a key role in the protection induced by intradermal DelNS1-LAIV, offering an alternative route for LAIV administration.
Article
Immunology
Adinda Kok, Ron A. M. Fouchier, Mathilde Richard
Summary: Avian influenza viruses from the GsGd lineage have posed a continuing threat to animal and human health since 1996. The genetic diversity of their HA surface glycoprotein presents a serious challenge to pandemic preparedness and vaccine design. Clinical studies on A/H5 influenza vaccination strategies show potential for antibody responses, but crucial questions remain unanswered for future research.
Review
Infectious Diseases
Tatjana Vilibic-Cavlek, Vladimir Savic, Thomas Ferenc, Anna Mrzljak, Ljubo Barbic, Maja Bogdanic, Vladimir Stevanovic, Irena Tabain, Ivana Ferencak, Snjezana Zidovec-Lepej
Summary: LCMV is a neglected zoonotic virus that can cause meningitis and fetal teratogen. Although human clinical cases are rare, it can lead to meningitis and transplant recipient infections. Clinicians should be aware of the potential risks of LCMV infection, especially in patients who have contact with rodents.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Immunology
Jinhwa Lee, Yonghai Li, Yuhao Li, A. Giselle Cino-Ozuna, Michael Duff, Yuekun Lang, Jingjiao Ma, Sunyoung Sunwoo, Juergen A. Richt, Wenjun Ma
Summary: Swine influenza is a significant disease for the swine industry, and traditional whole inactivated virus vaccines may cause vaccine-associated enhanced respiratory disease, while live attenuated influenza virus vaccines can effectively protect pigs from both homologous and heterologous virus infections. In this study, a chimeric bat influenza virus was used to develop a safe live vaccine to prevent swine influenza.
Article
Virology
Eric R. Weiss, Galit Alter, Javier Gordon Ogembo, Jennifer L. Henderson, Barbara Tabak, Yasin Bakis, Mohan Somasundaran, Manuel Garber, Liisa Selin, Katherine Luzuriaga
JOURNAL OF VIROLOGY
(2017)
Article
Virology
Jenny W. Che, Keith A. Daniels, Liisa K. Selin, Raymond M. Welsh
JOURNAL OF VIROLOGY
(2017)
Article
Gastroenterology & Hepatology
Vincent Mallet, Julie Bruneau, Julien Zuber, Cecile Alanio, Stephanie Leclerc-Mercier, Anne-Marie Roque-Afonso, Anke R. M. Kraft, Lucile Couronne, Dominique Roulot, Heiner Wedemeyer, Matthew L. Albert, Patrick Hillon, Liliane Laroche, Stanislas Pol, Olivier Hermine
JOURNAL OF HEPATOLOGY
(2017)
Article
Virology
Eric R. Weiss, Susanna L. Lamers, Jennifer L. Henderson, Alexandre Melnikov, Mohan Somasundaran, Manuel Garber, Liisa Selin, Chad Nusbaum, Katherine Luzuriaga
JOURNAL OF VIROLOGY
(2018)
Article
Gastroenterology & Hepatology
Jana Al-Ayoubi, Patrick Behrendt, Birgit Bremer, Pothakamuri Venkata Suneetha, Anett Gisa, Franziska Rinker, Michael P. Manns, Markus Cornberg, Heiner Wedemeyer, Anke R. M. Kraft
LIVER INTERNATIONAL
(2018)
Article
Gastroenterology & Hepatology
Franziska Rinker, Christine L. Zimmer, Christoph Hoener zu Siederdissen, Michael P. Manns, Anke R. M. Kraft, Heiner Wedemeyer, Niklas K. Bjoerkstroem, Markus Cornberg
JOURNAL OF HEPATOLOGY
(2018)
Article
Multidisciplinary Sciences
Steffen B. Wiegand, Bastian Beggel, Anika Wranke, Elmira Aliabadi, Jerzy Jaroszewicz, Cheng-Jian Xu, Yang Li, Michael P. Manns, Thomas Lengauer, Heiner Wedemeyer, Anke R. M. Kraft, Christine S. Falk, Markus Cornberg
SCIENTIFIC REPORTS
(2019)
Article
Virology
S. Klein, D. Ghersi, M. P. Manns, I. Prinz, M. Cornberg, A. R. M. Kraft
JOURNAL OF VIROLOGY
(2020)
Article
Immunology
Agnes Bonifacius, Sabine Tischer-Zimmermann, Anna C. Dragon, Daniel Gussarow, Alexander Vogel, Ulrike Krettek, Nina Goedecke, Mustafa Yilmaz, Anke R. M. Kraft, Marius M. Hoeper, Isabell Pink, Julius J. Schmidt, Yang Li, Tobias Welte, Britta Maecker-Kolhoff, Joerg Martens, Marc Moritz Berger, Corinna Lobenwein, Metodi Stankov, Markus Cornberg, Sascha David, Georg M. N. Behrens, Oliver Witzke, Rainer Blasczyk, Britta Eiz-Vesper
Summary: Research showed that active COVID-19 patients had high levels of anti-SARS-CoV-2 nucleocapsid and spike IgG, but overall reduced antiviral T cell responses due to inflammatory environment, expression of inhibitory molecules, and effector caspase activity in T cells.
Article
Gastroenterology & Hepatology
Yanqin Du, Olympia E. Anastasiou, Benedikt Strunz, Janina Scheuten, Birgit Bremer, Anke Kraft, Karolina Kleinsimglinhaus, Daniel Todt, Ruth Broering, Matthias Hardtke-Wolenski, Jun Wu, Dongliang Yang, Ulf Dittmer, Mengji Lu, Markus Cornberg, Niklas K. Bjorkstrom, Tanvi Khera, Heiner Wedemeyer
Summary: The study assessed the effects of HBsAg quantities on NK cell functionality in CHB patients, finding a reshaping of the NK cell pool towards more CD56(bright) NK cells during infection. Patients with low HBsAg levels displayed an activated NK cell phenotype with defective functional responses.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Elmira Aliabadi, Melanie Urbanek-Quaing, Benjamin Maasoumy, Birgit Bremer, Martin Grasshoff, Yang Li, Christian E. Niehaus, Heiner Wedemeyer, Anke R. M. Kraft, Markus Cornberg
Summary: The study found that HBV-specific T cell responses in hepatitis B patients are influenced by age and HBcrAg levels rather than HBsAg levels. Additionally, age and HBcrAg levels may impact cell response to PD-L1 inhibition.
Article
Virology
Jasmin Mischke, Sebastian Klein, Austin Seamann, Immo Prinz, Liisa Selin, Dario Ghersi, Markus Cornberg, Anke R. M. Kraft
Summary: Our study investigated the cross-reactive immune response in chronic viral infection, and found that cross-reactive CD8(+) T cells still exist and play a clinically relevant role in chronic infections. Furthermore, checkpoint inhibitor therapy had an impact on chronic infection but did not majorly affect heterologous immunity.
Article
Gastroenterology & Hepatology
Tammo L. Tergast, Benjamin Schulte, Marie Griemsmann, Julia Kahlhofer, Petra Dorge, Jan B. Hinrichs, Anke R. M. Kraft, Julius J. Schmidt, Patrick Behrendt, Heiner Wedemeyer, Markus Cornberg, Benjamin Maasoumy
Summary: This study suggests that diagnostic CM-CT does not increase the incidence of AKI or worsen kidney function in patients with decompensated cirrhosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cell Biology
Bowen Zhang, Zhenhua Zhang, Valerie A. C. M. Koeken, Saumya Kumar, Michelle Aillaud, Hsin-Chieh Tsay, Zhaoli Liu, Anke R. M. Kraft, Chai Fen Soon, Ivan Odak, Berislav Bosnjak, Anna Vlot, Morris A. Swertz, Uwe Ohler, Robert Geffers, Thomas Illig, Jochen Huehn, Antoine-Emmanuel Saliba, Leif Erik Sander, Reinhold Foerster, Cheng-Jian Xu, Markus Cornberg, Leon N. Schulte, Yang Li
Summary: This study identifies diverse genetic and epigenetic regulators that contribute to the severity of COVID-19 through single-cell analysis of patients.
Article
Gastroenterology & Hepatology
Maximilian Wubbolding, Juan Carlos Lopez Alfonso, Chun-Yen Lin, Sebastian Binder, Christine Falk, Jennifer Debarry, Paul Gineste, Anke R. M. Kraft, Rong-Nan Chien, Benjamin Maasoumy, Heiner Wedemeyer, Wen-Juei Jeng, Michael Meyer Hermann, Markus Cornberg, Christoph Honer zu Siederdissen
Summary: The study utilized machine learning to identify SIM combinations as predictors for early virological relapse after stopping NA treatment in HBeAg-negative patients. The combination of SIMs IL-2, MIG/CCL9, RANTES/CCL5, SCF, and TRAIL showed a high predictive value for VR, indicating the potential of SIM patterns in guiding treatment cessation in this patient population.
HEPATOLOGY COMMUNICATIONS
(2021)