Pattern Recognition Receptor MDA5 Modulates CD8+ T Cell-Dependent Clearance of West Nile Virus from the Central Nervous System

The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection

(2013) J. S. Errett et al.   JOURNAL OF VIROLOGY

Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses

(2013) Hyelim Cho et al.   NATURE MEDICINE

West Nile virus infection and immunity

(2013) Mehul S. Suthar et al.   NATURE REVIEWS MICROBIOLOGY

IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling

(2013) Helen M. Lazear et al.   PLoS Pathogens

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

(2012) Helene Minyi Liu et al.   Cell Host & Microbe

Timing and Magnitude of Type I Interferon Responses by Distinct Sensors Impact CD8 T Cell Exhaustion and Chronic Viral Infection

(2012) Yaming Wang et al.   Cell Host & Microbe

The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness

(2012) Mehul S. Suthar et al.   IMMUNITY

Critical Role of MDA5 in the Interferon Response Induced by Human Metapneumovirus Infection in Dendritic Cells and In Vivo

(2012) M. D. R. Banos-Lara et al.   JOURNAL OF VIROLOGY

Interferon Response Factors 3 and 7 Protect against Chikungunya Virus Hemorrhagic Fever and Shock

(2012) Penny A. Rudd et al.   JOURNAL OF VIROLOGY

Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication

(2012) L. B. Thackray et al.   JOURNAL OF VIROLOGY

CD8+ T Cells Use TRAIL To Restrict West Nile Virus Pathogenesis by Controlling Infection in Neurons

(2012) B. Shrestha et al.   JOURNAL OF VIROLOGY

An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo

(2012) Amy C. Wollish et al.   VIROLOGY

Immune Responses to West Nile Virus Infection in the Central Nervous System

(2012) Hyelim Cho et al.   Viruses-Basel

Uridine Composition of the Poly-U/UC Tract of HCV RNA Defines Non-Self Recognition by RIG-I

(2012) Gretja Schnell et al.   PLoS Pathogens

RNA sensor–induced type I IFN prevents diabetes caused by a β cell–tropic virus in mice

(2011) Stephen A. McCartney et al.   JOURNAL OF CLINICAL INVESTIGATION

Keratinocytes Are Cell Targets of West Nile Virus In Vivo

(2011) P.-Y. Lim et al.   JOURNAL OF VIROLOGY

The Naturally Attenuated Kunjin Strain of West Nile Virus Shows Enhanced Sensitivity to the Host Type I Interferon Response

(2011) S. Daffis et al.   JOURNAL OF VIROLOGY

Melanoma Differentiation-Associated Gene 5 Is Critical for Protection against Theiler's Virus-Induced Demyelinating Disease

(2011) Y.-H. Jin et al.   JOURNAL OF VIROLOGY

Beta Interferon Controls West Nile Virus Infection and Pathogenesis in Mice

(2011) H. M. Lazear et al.   JOURNAL OF VIROLOGY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

Cytosolic surveillance and antiviral immunity

(2011) Vijay AK Rathinam et al.   Current Opinion in Virology

MDA5 and TLR3 Initiate Pro-Inflammatory Signaling Pathways Leading to Rhinovirus-Induced Airways Inflammation and Hyperresponsiveness

(2011) Qiong Wang et al.   PLoS Pathogens

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Recognition of viruses by cytoplasmic sensors

(2010) Courtney Wilkins et al.   CURRENT OPINION IN IMMUNOLOGY

Type I IFN controls chikungunya virus via its action on nonhematopoietic cells

(2010) Clémentine Schilte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Polyinosinic:Polycytidylic Acid Boosts the Generation of Memory CD8 T Cells through Melanoma Differentiation-Associated Protein 5 Expressed in Stromal Cells

(2010) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Induction and Inhibition of Type I Interferon Responses by Distinct Components of Lymphocytic Choriomeningitis Virus

(2010) S. Zhou et al.   JOURNAL OF VIROLOGY

The Innate Immune Adaptor Molecule MyD88 Restricts West Nile Virus Replication and Spread in Neurons of the Central Nervous System

(2010) K. J. Szretter et al.   JOURNAL OF VIROLOGY

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

(2010) A. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rabies Virus Infection Induces Type I Interferon Production in an IPS-1 Dependent Manner While Dendritic Cell Activation Relies on IFNAR Signaling

(2010) Elizabeth J. Faul et al.   PLoS Pathogens

IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity

(2010) Mehul S. Suthar et al.   PLoS Pathogens

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo

(2010) Leonid Gitlin et al.   PLoS Pathogens

Toll-like Receptor 7 Mitigates Lethal West Nile Encephalitis via Interleukin 23-Dependent Immune Cell Infiltration and Homing

(2009) Terrence Town et al.   IMMUNITY

MDA5 and MAVS Mediate Type I Interferon Responses to Coxsackie B Virus

(2009) J. P. Wang et al.   JOURNAL OF VIROLOGY

Induction of IFN-β and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7

(2009) Stephane Daffis et al.   PLoS Pathogens

MDA5/RIG-I and virus recognition

(2008) Osamu Takeuchi et al.   CURRENT OPINION IN IMMUNOLOGY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor Necrosis Factor Alpha Protects against Lethal West Nile Virus Infection by Promoting Trafficking of Mononuclear Leukocytes into the Central Nervous System

(2008) B. Shrestha et al.   JOURNAL OF VIROLOGY

Mechanism of mda-5 Inhibition by Paramyxovirus V Proteins

(2008) K. S. Childs et al.   JOURNAL OF VIROLOGY

Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia

(2008) J. K. Roth-Cross et al.   JOURNAL OF VIROLOGY

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

(2008) S. Daffis et al.   JOURNAL OF VIROLOGY

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE

Evolution of MDA-5/RIG-I-dependent innate immunity: Independent evolution by domain grafting

(2008) D. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MDA-5 Recognition of a Murine Norovirus

(2008) Stephen A. McCartney et al.   PLoS Pathogens