The Frequency of CD127+ Hepatitis C Virus (HCV)-Specific T Cells but Not the Expression of Exhaustion Markers Predicts the Outcome of Acute HCV Infection

High-Programmed Death-1 Levels on Hepatitis C Virus-Specific T Cells during Acute Infection Are Associated with Viral Persistence and Require Preservation of Cognate Antigen during Chronic Infection

(2014) A. Rutebemberwa et al.   JOURNAL OF IMMUNOLOGY

The Common  -Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

(2014) A. L. Kinter et al.   JOURNAL OF IMMUNOLOGY

Successful Vaccination Induces Multifunctional Memory T-Cell Precursors Associated With Early Control of Hepatitis C Virus

(2012) Su–Hyung Park et al.   GASTROENTEROLOGY

Spontaneous Clearance of Chronic Hepatitis C Virus Infection Is Associated With Appearance of Neutralizing Antibodies and Reversal of T-Cell Exhaustion

(2012) Sukanya Raghuraman et al.   JOURNAL OF INFECTIOUS DISEASES

Delayed Induction, Not Impaired Recruitment, of Specific CD8+ T Cells Causes the Late Onset of Acute Hepatitis C

(2011) Eui–Cheol Shin et al.   GASTROENTEROLOGY

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

(2010) Bertram Bengsch et al.   PLoS Pathogens

Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution

(2009) V. Kasprowicz et al.   JOURNAL OF VIROLOGY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

(2009) Nobuhiro Nakamoto et al.   PLoS Pathogens

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

(2008) Nobuhiro Nakamoto et al.   GASTROENTEROLOGY

Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells

(2008) G. Badr et al.   JOURNAL OF VIROLOGY