Novel Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Entry That Act by Three Distinct Mechanisms

The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies

(2013) S. Gierer et al.   JOURNAL OF VIROLOGY

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Severe Acute Respiratory Syndrome Coronavirus Replication Inhibitor That Interferes with the Nucleic Acid Unwinding of the Viral Helicase

(2012) Adeyemi O. Adedeji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2

(2012) Anna-Winona Struck et al.   ANTIVIRAL RESEARCH

5-Aryl-4-carboxamide-1,3-oxazoles: Potent and selective GSK-3 inhibitors

(2012) Gabriella Gentile et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphatidylinositol 4-Kinase IIIβ Is Required for Severe Acute Respiratory Syndrome Coronavirus Spike-mediated Cell Entry

(2012) Ning Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is there a future for antiviral fusion inhibitors?

(2012) Ben Berkhout et al.   Current Opinion in Virology

Inhibitors of SARS-CoV entry – Identification using an internally-controlled dual envelope pseudovirion assay

(2011) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the Potential Treatment of Obesity and Diabetes

(2011) Yimin Qian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

Yeast Based Small Molecule Screen for Inhibitors of SARS-CoV

(2011) Matthew Frieman et al.   PLoS One

Different host cell proteases activate the SARS-coronavirus spike-protein for cell–cell and virus–cell fusion

(2011) Graham Simmons et al.   VIROLOGY

Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and Apoptosis

(2011) Marta L. DeDiego et al.   PLoS Pathogens

Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus

(2011) I-Chueh Huang et al.   PLoS Pathogens

Cathepsin L in metastatic bone disease: therapeutic implications

(2010) Gaetano Leto et al.   BIOLOGICAL CHEMISTRY

Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors

(2010) Iou-Jiun Kang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

A Small-Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T cells

(2010) P. P. Shah et al.   MOLECULAR PHARMACOLOGY

Inhibitors of Foot and Mouth Disease Virus Targeting a Novel Pocket of the RNA-Dependent RNA Polymerase

(2010) Ryan C. Durk et al.   PLoS One

TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds

(2009) Shiori Haga et al.   ANTIVIRAL RESEARCH

Novel Targets for Antiretroviral Therapy

(2009) Birgitt Dau et al.   DRUGS

Evidence that Ecotropic Murine Leukemia Virus Contamination in TZM-bl Cells Does Not Affect the Outcome of Neutralizing Antibody Assays with Human Immunodeficiency Virus Type 1

(2009) E. J. Platt et al.   JOURNAL OF VIROLOGY

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

(2009) I. Glowacka et al.   JOURNAL OF VIROLOGY

Cathepsin L, target in cancer treatment?

(2009) Jacqueline M. Lankelma et al.   LIFE SCIENCES

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

SC29EK, a Peptide Fusion Inhibitor with Enhanced  -Helicity, Inhibits Replication of Human Immunodeficiency Virus Type 1 Mutants Resistant to Enfuvirtide

(2008) T. Naito et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reviews Of Anti‐infective Agents: Maraviroc: The First of a New Class of Antiretroviral Agents

(2008) Rodger D. MacArthur et al.   CLINICAL INFECTIOUS DISEASES

Maraviroc: A CCR5-receptor antagonist for the treatment of HIV-1 infection

(2008) Sharon S. Lieberman-Blum et al.   CLINICAL THERAPEUTICS

Effects of inducing or inhibiting apoptosis on Sindbis virus replication in mosquito cells

(2008) H. Wang et al.   JOURNAL OF GENERAL VIROLOGY

Identification of Gammaretroviruses Constitutively Released from Cell Lines Used for Human Immunodeficiency Virus Research

(2008) Y. Takeuchi et al.   JOURNAL OF VIROLOGY

Differential role for low pH and cathepsin-mediated cleavage of the viral spike protein during entry of serotype II feline coronaviruses

(2008) Andrew D. Regan et al.   VETERINARY MICROBIOLOGY

Pharmacokinetics and tissue distribution of 3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzamide; a novel ALK5 inhibitor and a potential anti-fibrosis drug

(2008) Y. W. Kim et al.   XENOBIOTICA