Article
Microbiology
Yuki Iwaisako, Tadashi Watanabe, Mizuki Hanajiri, Yuichi Sekine, Masahiro Fujimuro
Summary: The KSHV ORF7 plays a key role in viral replication by regulating capsid formation, maintaining viral production, and promoting lytic replication through interactions with other terminase components.
Review
Biochemistry & Molecular Biology
Amanda de Oliveira Lopes, Pedro do Nascimento Marinho, Leticia d'Ambrosio de Souza Medeiros, Vanessa Salete de Paula
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) is a virus containing oncogenes and proteins that play a crucial role in regulating cellular functions and leading to Kaposi's sarcoma. Some of these genes have the potential to be therapeutic targets for Kaposi's sarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Qinqin Sun, Fan Wang, Qingyang Chen, Ronit Sarid, Xiaojuan Li, Ersheng Kuang
Summary: The lytic replication of Kaposi's sarcoma-associated herpesvirus (KSHV) is enhanced by ORF45, which upregulates the expression of ATF4 and LAMP3, leading to reprogrammed cellular transcription and translation that supports viral protein production.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Yuan Fang, Wenli Li, Ying Zhang, Chang Zhou, Huanwu Wu, Yiting Zhang, Tao Dai, Jinzhi Wang, Lei Wang, Tongqing Chen, Yulin Zhu, Linding Wang
Summary: The seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV) is high in Gansu, China, especially among certain ethnic groups and syphilis patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Microbiology
Chunhong Di, Guoxia Zheng, Yunheng Zhang, Enyu Tong, Yanli Ren, Yu Hong, Yang Song, Rong Chen, Xiaohua Tan, Lei Yang
Summary: The recombination signal binding protein for immunoglobulin kappa J region (RBPJ) plays a dual role in Kaposi's sarcoma-associated herpesvirus (KSHV) replication. Its interaction with replication and transcription activator (RTA) is essential for lytic replication, while the interaction with latency-associated nuclear antigen (LANA) facilitates latent infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Yuki Iwaisako, Tadashi Watanabe, Youichi Suzuki, Takashi Nakano, Masahiro Fujimuro
Summary: Although the formation and function of the alpha- and betaherpesvirus terminase complexes are well understood, the Kaposi's sarcoma-associated herpesvirus (KSHV) terminase complex is still largely uncharacterized. We previously reported the presence of soccer ball-like capsids in ORF7-deficient KSHV-harboring cells. Here, we demonstrate that ORF67.5 is required for terminal repeat (TR) cleavage, infectious virus production, and enhancement of the interaction between ORF7 and ORF29.
JOURNAL OF VIROLOGY
(2023)
Article
Microbiology
Sydney J. Bennett, Dicle Yalcin, Sara R. Privatt, Owen Ngalamika, Salum J. Lidenge, John T. West, Charles Wood
Summary: This study presents the first high-resolution epitope map of the latency-associated nuclear antigen (LANA) in Kaposi sarcoma (KS) patients and asymptomatic KSHV-infected individuals using high-throughput phage display (VirScan). The results show that a 24-amino acid peptide on LANA is highly antigenic in both groups, regardless of co-infection with human immunodeficiency virus (HIV). HIV co-infection is associated with a lower response to this epitope in KS patients, but has little to no effect in the absence of cancer. Further studies on this identified epitope may have therapeutic, diagnostic, or viral decoy potential. The application of these findings could be important for designing effective vaccines and therapeutics for KSHV infection and prevention of progression to KS.
Review
Virology
Lindsey Barrett, Lu Dai, Shanzhi Wang, Zhiqiang Qin
Summary: This article summarizes how KSHV utilizes extracellular vesicles (EVs) to create favorable environments for viral spread and persistence while evading immune responses. EVs play a significant role in the development and function of the immune system.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Qian Chen, Jiangtao Chen, Yuqing Li, Dawei Liu, Yan Zeng, Zheng Tian, Akbar Yunus, Yong Yang, Jie Lu, Xinghua Song, Yan Yuan
Summary: The prevalence of KSHV infection is significantly elevated in Uyghur osteosarcoma patients, with the virus being associated with some osteosarcomas. The study suggests that KSHV infection is a risk factor for osteosarcoma, representing a newly identified viral-associated endemic cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Sophie Grabar, Dominique Costagliola
Summary: An air mattress is a non-breathable sleeping aid commonly used for camping or guests' accommodation.
Article
Virology
Isaura Vanessa Gutierrez, Poulomee Sarkar, Cyprian C. Rossetto
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus that causes serious diseases in humans. During lytic replication, the virus produces new virions through a cascade of gene expression. ORF59, a viral factor expressed during this process, plays a crucial role in DNA synthesis and interacts with histones and cellular methyltransferases. Studies on ORF59 deletions show specific amino acid regions are required for histone interaction and nuclear localization but not for DNA synthesis, demonstrating its essential role during lytic replication.
JOURNAL OF VIROLOGY
(2021)
Review
Microbiology
Floriane Lagadec, Vincent Parissi, Paul Lesbats
Summary: The H2A-H2B acidic patch has been identified as a key element for nucleosome recognition and chromatin structure regulation. The folding of chromatin arrays relies on the interaction between the histone H4 tail and the adjacent nucleosome acidic patch. Cellular factors and viral proteins have been found to bind to the acidic patch, influencing the chromatin state and potentially affecting viral infections.
Article
Microbiology
Su-Kyung Kang, Myung-Ju Lee, Ho-Hyun Ryu, Jisu Lee, Myung-Shin Lee
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to various diseases, efficient virus production and isolation are crucial for research. DMSO shows promise in enhancing KSHV viral production by affecting its lytic genes, and the activation of JNK is implicated in this process.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Virology
Thomas F. Schulz, Anika Freise, Saskia C. Stein
Summary: Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic herpesvirus with latencyassociated nuclear antigen (LANA) playing crucial roles in viral persistence, replication, partitioning, establishment of latency, and immune evasion. LANA mediates replication of the viral genome, attaches episomes to daughter cells during cell division, establishes latency in newly infected cells, modulates cellular proteome, and interferes with the immune system.
CURRENT OPINION IN VIROLOGY
(2023)
Article
Microbiology
Tate Tabtieng, Rachel C. Lent, Machika Kaku, Alvaro Monago Sanchez, Marta Maria Gaglia
Summary: Type I interferons play a crucial role in infectious and inflammatory diseases. Viruses have developed strategies to suppress the production of type I interferons, and apoptotic caspases have emerged as important regulators of type I interferon signaling. This study reveals that caspase activity inhibits the DNA sensor cGAS during KSHV infection, blocking the antiviral type I interferon response. These findings provide insights into the mechanisms of viral immune evasion and can inform targeted therapeutic strategies for viral infections.