Article
Cell Biology
Shanshan Wan, Yiwen Zhou, Qiong Huang, Yanning Yang
Summary: Dot1l plays a significant role in HSV-1-induced keratitis, and its inhibition can alleviate corneal injury, oxidative stress, and inflammation. The study also suggests that inhibiting Dot1l can reduce HSV-1-induced oxidative stress and inflammation through the p38 MAPK pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Immunology
Tian Yu, Fabian Schuette, Maria Christofi, John V. Forrester, Gerard J. Graham, Lucia Kuffova
Summary: Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1). The atypical chemokine receptor-2 (ACKR2) has been found to be upregulated during corneal HSV-1 infection and is involved in regulating the inflammatory response and neovascularization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhongnan Xiao, Danmin Shen, Ting Lan, Chao Wei, Zhaoli Luo, Wen Chen, Yurui Zhang, Chenguang Zhang, Yamei Wang, Yabin Lu, Peipei Wang, Fei Yang, Qian Li, Liye Hu, Weihua Wu
Summary: This study found that diabetic hyperglycemia exacerbates the outcomes of intracerebral hemorrhagic stroke by increasing neutrophil infiltration and altering gene expression profile. Supplementing lactoferrin or inhibiting neuronal ferroptosis could potentially improve the acute outcomes of diabetic intracerebral hemorrhagic stroke.
Article
Ophthalmology
Ji-Ni Qiu, Fei-Fei Huang, Chun-Hong Liu, Wen-Jun Cao, Chao-Ran Zhang
Summary: This study aims to report the clinical features and diagnosis of atypical stromal herpes simplex keratitis (HSK), and evaluate the diagnostic efficiency of tear HSV-sIgA in atypical HSK. The tear HSV-sIgA test can help provide quick diagnosis of atypical stromal HSK caused by HSV infection.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Virology
Mashidur Rana, Mizumi Setia, Pratima K. Suvas, Anish Chakraborty, Susmit Suvas
Summary: Reactive oxygen species (ROS) play a crucial role in herpes stromal keratitis (HSK), with neutrophils being the primary cells responsible for ROS generation. NOX2 is involved in ROS production in neutrophils. However, manipulating ROS levels in neutrophils may help alleviate the severity of HSK, and NOX2 is not the main contributor to ROS generation in neutrophils.
JOURNAL OF VIROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Di Yin, Sikai Ling, Dawei Wang, Yao Dai, Hao Jiang, Xujiao Zhou, Soren R. Paludan, Jiaxu Hong, Yujia Cai
Summary: The study targeted HSV-1 genomes directly using mRNA-carrying lentiviral particles (HELP), which efficiently blocked HSV-1 replication and reduced the occurrence of HSK in three different infection models. HELP was capable of eliminating the viral reservoir via retrograde transport from corneas to trigeminal ganglia, while inhibiting viral replication in human-derived corneas without causing off-target effects.
NATURE BIOTECHNOLOGY
(2021)
Article
Ophthalmology
Radhika Natarajan, Hiren D. Matai, Sundaresan Raman, Subham Kumar, Swetha Ravichandran, Samyuktha Swaminathan, John Sahaya Rani Alex
Summary: The study shows that DL algorithm can be a positive aid to diagnose VK, especially in primary care centers where appropriate laboratory facilities or expert manpower are not available.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Matteo Tardelli, Francesca V. Bruschi, Claudia D. Fuchs, Thierry Claudel, Nicole Auer, Victoria Kunczer, Onne A. H. O. Ronda, Henkjan J. Verkade, Tatjana Stojakovic, Hubert Scharnagl, Michael Trauner
Summary: The synergistic contribution of MGL and PNPLA3 to the progression of NAFLD remains unclear. This study demonstrates that combined deficiency of MGL and PNPLA3 in mice results in weight gain on a chow diet, and when challenged by a high-fat diet, DKO mice exhibit more significant hepatic FA synthesis and reduced beta-oxidation compared to Mgl(-/-) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Nibedita Das, Joyeeta Das, Dipanjan Pal
Summary: A 73-year-old woman presented with symptoms of herpetic keratitis during the recovery phase of COVID-19. Treatment with acyclovir and steroids led to improvement. This report adds knowledge about ocular infections during the recovery phase of COVID-19.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Ruknesvary Subramaniam, Khairy Shamel Sonny Teo, Julieana Muhammed
Summary: This article presents the case of a 21-year-old female contact lens wearer who exhibited Acanthamoeba keratitis-like corneal ring infiltration, which was later diagnosed as HSV keratitis. Despite standard anti-amoebic therapy, her keratitis worsened, highlighting the varied manifestations of HSV keratitis and the need for timely diagnosis and treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Poonam Shrestha, Santosh Paudel
Summary: This study aimed to determine the prevalence of stromal keratitis among herpes simplex keratitis patients in a tertiary eye hospital.
JOURNAL OF NEPAL MEDICAL ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Aaron R. Kolb, Sarah Ferguson, Inna Larsen, Curtis Brandt
Summary: Sex-related differences in the incidence or severity of infection have been observed for various viruses. However, in the case of HSV-1 ocular infection in BALB/c mice, no significant sex-specific ocular pathologies were found, regardless of the virulence phenotype. These findings suggest that the use of both sexes may not be necessary for most ocular infection studies.
Article
Immunology
Xiaoting Wu, Danyu You, Jiong Cui, Liyan Yang, Liyu Lin, Yi Chen, Changsheng Xu, Guili Lian, Jianxin Wan
Summary: C3 plays an important role in inflammation and kidney injury. This study found that ischemia reperfusion injury (IRI) in the kidney leads to increased infiltration of neutrophils and formation of neutrophil extracellular traps (NETs). Inhibiting neutrophil infiltration can reduce kidney injury and inflammation. C3 deficiency can ameliorate acute kidney injury (AKI) by reducing neutrophil infiltration and the formation of NETs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Ophthalmology
Xiaole Li, Manav Nayeni, Monali S. S. Malvankar-Mehta
Summary: This study systematically compared different interventions for treating HSK and their patient outcomes. The results showed that corticosteroids and antivirals were most effective when used together. Oral acyclovir was as effective as its ointment counterpart. Tapering corticosteroid use and using it for at least 10 weeks could lead to greater therapeutic benefits. Anti-inflammatory drugs like flurbiprofen, cyclosporine-A, and tacrolimus were safe and effective for treating HSK. Long-term follow-up and randomized controlled trials could provide further insights on these potential alternatives.
OPHTHALMIC EPIDEMIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Shuyu Xiao, Yang Yang, Wanhong Miao, Chunming Lyu, Jinhua Tao, Ying Yu
Summary: This study found that Yiqi Jiedu formula alleviated corneal inflammation in mice with recurrent herpes simplex virus keratitis by enhancing the STAT5 signaling pathway, promoting the differentiation of Treg cells, reducing the proportion of pro-inflammatory cells, and reducing corneal lesions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yen-Chung Lai, Yung-Chun Chuang, Chih-Peng Chang, Yee-Shin Lin, Guey-Chuen Perng, Han-Chung Wu, Shie-Liang Hsieh, Trai-Ming Yeh
ANTIVIRAL RESEARCH
(2018)
Article
Critical Care Medicine
Chiao-Hsuan Chao, Hong-Ru Chen, Yung-Chun Chuang, Trai-Ming Yeh
Article
Infectious Diseases
Liang-Hsuan Lu, Chiao-Hsuan Chao, Trai-Ming Yeh
JOURNAL OF INFECTION
(2019)
Article
Microbiology
Chiao-Hsuan Chao, Wei-Chueh Wu, Yen-Chung Lai, Pei-Jane Tsai, Guey-Chuen Perng, Yee-Shin Lin, Trai-Ming Yeh
Article
Immunology
Yu-San Kao, Chia-Yi Yu, Hong-Jyun Huang, Sen-Mao Tien, Wan-Yu Wang, Martyr Yang, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin, Shu-Wen Wan
JOURNAL OF IMMUNOLOGY
(2019)
Article
Medicine, Research & Experimental
Ying-Ray Lee, Shan-Ying Wu, Ruei-Yi Chen, Yee-Shin Lin, Trai-Ming Yeh, Hsiao-Sheng Liu
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2020)
Review
Microbiology
Yen-Chung Lai, Chiao-Hsuan Chao, Trai-Ming Yeh
Article
Biochemistry & Molecular Biology
Zi-Yi Lu, Miao-Huei Cheng, Chia-Yi Yu, Yee-Shin Lin, Trai-Ming Yeh, Chia-Ling Chen, Chien-Chin Chen, Shu-Wen Wan, Chih-Peng Chang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Immunology
Hong-Jyun Huang, Martyr Yang, Hsin-Wei Chen, Shuying Wang, Chih-Peng Chang, Tzong-Shiann Ho, Yu-San Kao, Sen-Mao Tien, Hsing-Han Lin, Po-Chun Chang, Yen-Chung Lai, Yu-Peng Hsiao, Yi-Ling Liu, Chiao-Hsuan Chao, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin, Shu-Wen Wan
Summary: This study developed a modified DENV vaccine candidate with enhanced features by combining modifications of two DENV proteins. The vaccine candidate showed protective effects against DENV infection in a mouse model, indicating its potential clinical application.
Article
Microbiology
Sen-Mao Tien, Po-Chun Chang, Yen-Chung Lai, Yung-Chun Chuang, Chin-Kai Tseng, Yu-San Kao, Hong-Jyun Huang, Yu-Peng Hsiao, Yi-Ling Liu, Hsing-Han Lin, Chien-Chou Chu, Miao-Huei Cheng, Tzong-Shiann Ho, Chih-Peng Chang, Shu-Fen Ko, Che-Piao Shen, Robert Anderson, Yee-Shin Lin, Shu-Wen Wan, Trai-Ming Yeh
Summary: Dengue virus (DENV) is a global health problem without effective treatment. This study demonstrates the potential of humanized anti-NS1 monoclonal antibodies (mAbs) as a therapeutic tool for DENV infection. The humanized mAbs showed therapeutic benefits in reducing bleeding time and skin hemorrhage, and they also inhibited vascular permeability and enhanced cytolysis of DENV-infected cells.
Article
Immunology
Yen-Chung Lai, Yu-Wei Cheng, Chiao-Hsuan Chao, Yu-Ying Chang, Chi-De Chen, Wei-Jiun Tsai, Shuying Wang, Yee-Shin Lin, Chih-Peng Chang, Woei-Jer Chuang, Li-Yin Chen, Ying-Ren Wang, Sui-Yuan Chang, Wenya Huang, Jen-Ren Wang, Chin-Kai Tseng, Chun-Kuang Lin, Yung-Chun Chuang, Trai-Ming Yeh
Summary: In COVID-19 patients, elevated levels of ACE2 antibodies were found to cross-react with S1-RBD antibodies, suggesting a potential mechanism of immune response induced by SARS-CoV-2 infection. This cross-reactivity highlights the complex interactions between the virus and the host immune system in COVID-19 pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yi-Ling Cheng, Chiao-Hsuan Chao, Yen-Chung Lai, Kun-Han Hsieh, Jen-Ren Wang, Shu-Wen Wan, Hong-Jyun Huang, Yung-Chun Chuang, Woei-Jer Chuang, Trai-Ming Yeh
Summary: This study confirms the presence of antibodies related to SARS-CoV-2 in dengue virus patients, and these antibodies can cross-react with proteins of the dengue virus. These antibodies can inhibit the pathological reactions caused by dengue virus infection, potentially providing some level of protection against dengue virus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chiao-Hsuan Chao, Dayna Cheng, Sheng-Wen Huang, Yung-Chun Chuang, Trai-Ming Yeh, Jen-Ren Wang
Summary: This study collected serum samples from 113 Taiwan participants after receiving different SARS-CoV-2 vaccines and compared the differences in immune responses. The results showed that mRNA vaccines elicited higher levels of antibodies and had higher broadly neutralizing ability compared to AZD1222. Additionally, the study found a significant increase in anti-ACE2 autoantibodies after vaccination.
FRONTIERS IN IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
T. M. Yeh
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Review
Cell Biology
Hong-Ru Chen, Yen-Chung Lai, Trai-Ming Yeh
JOURNAL OF BIOMEDICAL SCIENCE
(2018)