期刊
JOURNAL OF VIROLOGY
卷 87, 期 13, 页码 7781-7786出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00037-13
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资金
- [CA-84941]
- [CA-33616]
The adenovirus E1A C-terminal region restrains oncogenic transformation through interaction with three distinct cellular protein complexes that include the DYRK1A/1B/HAN11 complex. The E6 proteins of beta-human papillomaviruses (beta-HPVs) also interact with the DYRK1/HAN11 complex. A variant of HPV5 E6 frequently found in epidermodysplasia verruciformis skin lesions interacted less efficiently with DYRK1A/HAN11. The E6 variant and E7 of HPV5 efficiently coimmortalized primary epithelial cells, suggesting that naturally arising variants may contribute potential oncogenic activities of beta-HPV E6 proteins.
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