期刊
JOURNAL OF VIROLOGY
卷 87, 期 12, 页码 7191-7196出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03284-12
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资金
- Center for Cancer Research at the National Cancer Institute, NIH
- IATAP program at NIH
We describe cryo-electron microscopic studies of the interaction between the ectodomain of the trimeric HIV-1 envelope glycoprotein (Env) and Z13e1, a broadly neutralizing antibody that targets the membrane-proximal external region (MPER) of the gp41 subunit. We show that Z13e1-bound Env displays an open quaternary conformation similar to the CD4-bound conformation. Our results support the idea that MPER-directed antibodies, such as Z13e1, block viral entry by interacting with Env at a step after CD4 activation.
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