Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
Article
Biochemistry & Molecular Biology
Davide Maestri, Giorgia Napoletani, Andrew Kossenkov, Sarah Preston-Alp, Lisa B. Caruso, Italo Tempera
Summary: This study found that PARP1 affects the binding of CTCF/Cohesin, leading to disruption of the three-dimensional structure of EBV and altered viral gene expression. Additionally, different types of EBV latency exhibit distinct three-dimensional structures and variations in viral gene expression. The study also revealed differences in H3K27ac-enriched interactions and a link between the EBV genome and the human genome in cellular transformation.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Immunology
Yaxian Ma, Peiling Zhang, Yuhan Bao, Hui Luo, Jiachen Wang, Liang Huang, Miao Zheng
Summary: Chronic active Epstein-Barr virus (CAEBV) disease is a high-mortality disease characterized by persistent infectious mononucleosis-like symptoms. This study analyzed the outcomes of PD-1 inhibitors treatment for CAEBV patients and found that the treatment had a high response rate and tolerable toxicity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yoshimi Enose-Akahata, Limin Wang, Fahad Almsned, Kory R. Johnson, Yair Mina, Joan Ohayon, Xin Wei Wang, Steven Jacobson
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), and the cause of MS remains unknown. This study investigated the antibody responses against various viruses in the cerebrospinal fluid (CSF) and serum of MS patients, and found significant differences compared to healthy volunteers, as well as a pattern of antibody responses against multiple viruses, including Epstein-Barr virus. These findings indicate that virus-specific antibody signatures might reflect the disease-associated inflammatory milieu in the CSF of patients with neuroinflammatory diseases.
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Immunology
S. Chatterjee, B. S. Sanjeev
Summary: By constructing a disease-gene network, the relationship between Epstein-Barr virus (EBV) and different types of cancers (Gastric cancer, Nasopharyngeal cancer, Hodgkin's lymphoma and Burkitt's lymphoma) was investigated, and important genes associated with EBV were identified. Through functional enrichment analysis, it was found that EBV affects critical pathways related to cellular growth arrest/apoptosis. Therefore, BCR-ABL1 tyrosine kinase inhibitors may have potential clinical applications in inhibiting BCR-mediated EBV activation.
MICROBIAL PATHOGENESIS
(2023)
Review
Biochemistry & Molecular Biology
Mathias Montenarh, Friedrich A. Graesser, Claudia Goetz
Summary: Protein kinase CK2 is a versatile kinase that phosphorylates various cellular and viral proteins, playing important roles in cellular signaling, cell proliferation, apoptosis, angiogenesis, immune response, migration, and invasion. It is also involved in viral infection and the generation of cancer cells. Specifically, in Epstein-Barr virus infection, CK2 phosphorylates viral and cellular proteins, contributing to virus replication and cell transformation.
Article
Multidisciplinary Sciences
Munetoshi Hinata, Tetsuo Ushiku
Summary: A histology-based deep learning model was constructed to efficiently screen EBV and MSI/dMMR subtypes in gastric cancers, showing high accuracy in detecting the subgroup and highlighting intraepithelial lymphocytosis as a discriminative characteristic shared by EBV and MSI/dMMR tumors. This model offers a potential economical and less time-consuming alternative for stratifying patients who respond to ICIs.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Francesco Baccianti, Charlene Masson, Susanne Delecluse, Zhe Li, Remy Poirey, Henri-Jacques Delecluse
Summary: EBV efficiently infects and transforms B lymphocytes by activating viral gene expression and manipulating cellular pathways to limit the immune response, according to this study. The viral particle components sequentially activate proinflammatory B lymphocyte signaling pathways, leading to viral gene expression and cytokine release. However, infection also triggers the expression of ZFP36L1, a stress protein that limits the cytokine response. This study highlights the complex interactions between EBV and host cells during infection and transformation.
Article
Biochemical Research Methods
Hansaim Lim, Chung-Jung Tsai, Ozlem Keskin, Ruth Nussinov, Attila Gursoy
Summary: HMI-PRED 2.0 is a publicly available web service that predicts host-microbe protein-protein interaction using interface mimicry. It aims to be user-friendly without requiring extensive computational experience.
Article
Multidisciplinary Sciences
Tobias Lanz, R. Camille Brewer, Peggy P. Ho, Jae-Seung Moon, Kevin M. Jude, Daniel Fernandez, Ricardo A. Fernandes, Alejandro M. Gomez, Gabriel-Stefan Nadj, Christopher M. Bartley, Ryan D. Schubert, Isobel A. Hawes, Sara E. Vazquez, Manasi Iyer, J. Bradley Zuchero, Bianca Teegen, Jeffrey E. Dunn, Christopher B. Lock, Lucas B. Kipp, Victoria C. Cotham, Beatrix M. Ueberheide, Blake T. Aftab, Mark S. Anderson, Joseph L. DeRisi, Michael R. Wilson, Rachael J. M. Bashford-Rogers, Michael Platten, K. Christopher Garcia, Lawrence Steinman, William H. Robinson
Summary: Multiple sclerosis (MS) is an autoimmune disease where autoreactive lymphocytes attack the central nervous system. Epstein-Barr virus (EBV) infection has been linked to MS, with molecular mimicry between EBV nuclear antigen 1 (EBNA1) and central nervous system protein GlialCAM. EBNA1 immunization exacerbates disease in MS mouse models and anti-EBNA1 and anti-GlialCAM antibodies are prevalent in MS patients, providing a mechanistic link between MS and EBV and guiding the development of new MS therapies.
Article
Medicine, General & Internal
Yin Xu, Ayako Hiyoshi, Kelsi A. Smith, Fredrik Piehl, Tomas Olsson, Katja Fall, Scott Montgomery
Summary: The study suggests that having infectious mononucleosis in childhood and especially adolescence is a risk factor associated with a diagnosis of multiple sclerosis, independent of shared familial factors.
Article
Multidisciplinary Sciences
Linlin Zhang, Mengjia Liu, Meng Zhang, Junhong Ai, Jiao Tian, Ran Wang, Zhengde Xie
Summary: Infectious mononucleosis (IM) is an acute syndrome associated with primary Epstein-Barr virus (EBV) infection. The exact pathogenic mechanism of IM remains unclear and there is currently no effective treatment. B cells and NK cells play important roles in IM, while the balance between CD4+ T cells and CD8+ T cells is crucial for lifelong control of the disease. Transcriptome sequencing of different cell populations involved in IM can help understand their functions and pathogenic mechanisms.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Immunology
Mariann Gyoengyoesi, Dominika Lukovic, Julia Mester-Tonczar, Katrin Zlabinger, Patrick Einzinger, Andreas Spannbauer, Victor Schweiger, Katharina Schefberger, Eslam Samaha, Jutta Bergler-Klein, Martin Riesenhuber, Christian Nitsche, Christian Hengstenberg, Patrick Mucher, Helmuth Haslacher, Monika Breuer, Robert Strassl, Elisabeth Puchhammer-Stoeckl, Christian Loewe, Dietrich Beitzke, Ena Hasimbegovic, Thomas A. Zelniker
Summary: This study evaluated the reactivation of parvovirus-B19 and Herpesviridae family members in patients with long-COVID syndrome and found that vaccination with monovalent COVID-19 vaccines was associated with reduced fatigue and multiorgan symptoms. It also led to lower levels of DNA virus-related IgM, plasma IgG subfractions, cytomegalovirus IgG and IgM, and EBV IgM titers.
Article
Immunology
Guang-Qiang Meng, Jing-Shi Wang, Yi-Ni Wang, Na Wei, Zhao Wang
Summary: These findings suggest that rituximab-containing regimens are effective in treating EBV-HLH patients with predominately B cell infection, especially for eliminating EBV. However, the treatment may not be as effective for patients with T and NK cell predominated EBV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katherine H. Reiter, Anita Ramachandran, Xue Xia, Lauren E. Boucher, Juergen Bosch, Michael J. Matunis
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Multidisciplinary Sciences
Ke Zhang, Christopher J. Donnelly, Aaron R. Haeusler, Jonathan C. Grima, James B. Machamer, Peter Steinwald, Elizabeth L. Daley, Sean J. Miller, Kathleen M. Cunningham, Svetlana Vidensky, Saksham Gupta, Michael A. Thomas, Ingie Hong, Shu-Ling Chiu, Richard L. Huganir, Lyle W. Ostrow, Michael J. Matunis, Jiou Wang, Rita Sattler, Thomas E. Lloyd, Jeffrey D. Rothstein
Article
Biochemical Research Methods
Caelin Cubenas-Potts, Tharan Srikumar, Christine Lee, Omoruyi Osula, Divya Subramonian, Xiang-Dong Zhang, Robert J. Cotter, Brian Raught, Michael J. Matunis
Article
Microbiology
Renfeng Li, Gangling Liao, Raja Sekhar Nirujogi, Sneha M. Pinto, Patrick G. Shaw, Tai-Chung Huang, Jun Wan, Jiang Qian, Harsha Gowda, Xinyan Wu, Dong-Wen Lv, Kun Zhang, Srikanth S. Manda, Akhilesh Pandey, S. Diane Hayward
Editorial Material
Cell Biology
Christine C. Lee, Michael J. Matunis
Article
Biochemistry & Molecular Biology
Dylan McLaughlin, Christopher T. Coey, Wei-Chih Yang, Alexander C. Drohat, Michael J. Matunis
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Biotechnology & Applied Microbiology
Dong-Wen Lv, Jun Zhong, Kun Zhang, Akhilesh Pandey, Renfeng Li
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2017)
Article
Cell Biology
Kun Zhang, Dong-Wen Lv, Renfeng Li
Article
Microbiology
Dong-Wen Lv, Kun Zhang, Renfeng Li
Article
Biochemistry & Molecular Biology
Katherine Reiter, Debaditya Mukhopadhyay, Hong Zhang, Lauren E. Boucher, Nirbhay Kumar, Juergen Bosch, Michael J. Matunis
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Christopher T. Coey, Megan E. Fitzgerald, Atanu Maiti, Katherine H. Reiter, Catherine M. Guzzo, Michael J. Matunis, Alexander C. Drohat
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Cell Biology
Caelin Cubenas-Potts, Jacqueline D. Goeres, Michael J. Matunis
MOLECULAR BIOLOGY OF THE CELL
(2013)
Editorial Material
Biochemistry & Molecular Biology
Jian Lu, Michael J. Matunis
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Reuven Wiener, Anthony T. DiBello, Patrick M. Lombardi, Catherine M. Guzzo, Xiangbin Zhang, Michael J. Matunis, Cynthia Wolberger
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2013)
Article
Multidisciplinary Sciences
Catherine M. Guzzo, Alison Ringel, Eric Cox, Ijeoma Uzoma, Heng Zhu, Seth Blackshaw, Cynthia Wolberger, Michael J. Matunis