期刊
JOURNAL OF VIROLOGY
卷 86, 期 7, 页码 4024-4028出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.06397-11
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资金
- ANPCyT-FONARSEC [PICT-PRH 2008-00315]
- NIH [AI074879, AI057159, CA107023]
- ANPCyT [2007-761]
- UBA [2008-035]
- Consejo Nacional de Investigaciones Cientificas y Tecnologicas
- Swiss National Science Foundation
- UCLA MBI
Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, as well as replication of infectious Junin virus. Our data indicate that all NW hemorrhagic fever arenaviruses utilize a common hTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadly effective in treating South American hemorrhagic fevers.
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