Article
Biology
Robert LeDesma, Brigitte Heller, Abhishek Biswas, Stephanie Maya, Stefania Gili, John Higgins, Alexander Ploss
Summary: This study reveals that the multifunctional protein ORF1 of Hepatitis E virus (HEV) is crucial for genome replication and is not regulated by proteolytic processing. The essential role of six cysteines in the pPCP domain in viral replication is associated with the coordination of divalent metal ions. Moreover, the pPCP domain can only rescue viral genome replication when expressed in the context of the full-length ORF1 protein.
Review
Medicine, General & Internal
Camille Peneau, Jessica Zucman-Rossi, Jean-Charles Nault
Summary: Virus-related liver carcinogenesis, including chronic hepatitis B and C infections, is a major contributor to cancer-related deaths worldwide. Mechanisms such as chronic inflammation and cirrhosis, viral insertional mutagenesis, and expression of oncogenic proteins play key roles in the oncogenic properties of HBV infection. Additionally, adeno associated virus type 2 (AAV2) insertion mutagenesis has been linked to the occurrence of HCC in non-cirrhotic patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Virology
Hui-Chun Li, Chee-Hing Yang, Shih-Yen Lo
Summary: The life cycle of the hepatitis C virus can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release. The replication of HCV genomic RNA is regulated by various factors and has led to the development of direct-acting antivirals targeting the replication complex.
Article
Multidisciplinary Sciences
Lijun Zhang, Chuhe Liu, Liufang Yin, Cheng Huang, Shengjie Fan
Summary: Hepatic fibrosis is a late stage process of chronic liver diseases, and blocking this process is beneficial for treatment and recovery. Mangiferin has been found to relieve tissue fibrosis in animal models through anti-inflammatory and anti-oxidative effects. This study investigated the effects of mangiferin on CCl4-induced liver fibrosis in mice and found that it alleviated liver damage and reduced collagen accumulation through inhibiting NF-kappa B signaling.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Akash Kumar, Preeti Hooda, Anindita Puri, Radhika Khatter, Mohammed S. Al-Dosari, Neha Sinha, Mohammad K. Parvez, Deepak Sehgal
Summary: Hepatitis E Virus (HEV) is a RNA virus that requires modulation of specific enzymes for infection prevention. Methotrexate and compound A have been found to inhibit the activity of HEV helicase, thereby inhibiting HEV RNA replication.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Review
Microbiology
Chonghui Xu, Jizheng Chen, Xinwen Chen
Summary: Hepatitis viruses are the primary causative agents of hepatitis and pose a major public health issue globally. The host innate immune system acts as the first line of defense against these viruses. However, hepatitis viruses evade host immune surveillance through various strategies, compromising the innate immune response and creating a favorable environment for viral replication.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhongyao Qian, Chenchen Yang, Liangheng Xu, Houfack K. Mickael, Shuangfeng Chen, Yike Zhang, Yueping Xia, Tengyuan Li, Wenhai Yu, Fen Huang
Summary: Hepatitis E virus-encoded miRNA (HEV-miR-A6) activates SIRP-alpha to promote viral replication by inhibiting the expression of type I interferon beta (IFN-beta).
Article
Microbiology
Harini Sooryanarain, S. Ansar Ahmed, Xiang-Jin Meng
Summary: The study found that progesterone significantly increases HEV replication in human liver cells, but does not modulate HEV-induced interferon response. PGRMC1/2 receptors affect the levels of HEV-induced IFN-lambda 1 expression via the ERK pathway, resulting in reduced HEV replication.
Article
Microbiology
Yang Wang, Hongling He, Jiesen Li, Luman Chen, Jun Luo, Yanqi Kuang, Ziyu Lv, Ruqi Fan, Boyue Zhang, Yongwen Luo, Xiaofeng Guo
Summary: Studies have shown that RABV infection can induce autophagy in BV2 cells, and this autophagy is positively correlated with the viral load. A higher multiplicity of infection leads to stronger autophagy response in cells.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Richeng Mao, Minhui Dong, Zhongliang Shen, Hu Zhang, Yuanjie Liu, Dawei Cai, Bidisha Mitra, Jiming Zhang, Haitao Guo
Summary: DDX17 is a member of the DEAD-box helicase family proteins that inhibits HBV replication through reducing cytoplasmic encapsidated pgRNA levels in a helicase-dependent manner, competing with HBV polymerase to bind to pgRNA at the 5' epsilon motif.
JOURNAL OF VIROLOGY
(2021)
Article
Gastroenterology & Hepatology
Lu Sun, Hui Feng, Ichiro Misumi, Takayoshi Shirasaki, Lucinda Hensley, Olga Gonzalez-Lopez, Itoe Shiota, Wei-Chun Chou, Jenny P. -Y. Ting, John M. Cullen, Dale O. Cowley, Jason K. Whitmire, Stanley M. Lemon
Summary: In this study, the researchers used gene editing to make mice susceptible to cleavage by the 3ABC protein, which enhanced HAV replication and disrupted disease progression. However, cleavage of mMAVS alone was not enough to overcome the host-species barrier to HAV infection in mice.
JOURNAL OF HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Angelo Zambam de Mattos, Jose D. Debes, Andre Boonstra, Ju-Dong Yang, Domingo C. Balderramo, Giovana D. P. Sartori, Angelo Alves de Mattos
Summary: Chronic infections caused by hepatitis B and hepatitis C viruses are major contributors to hepatocellular carcinoma (HCC) worldwide. Effective measures to reduce the burden of viral hepatitis-related HCC include universal vaccination against hepatitis B, identification and treatment of infected individuals, and surveillance of high-risk groups for early detection of tumors.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Microbiology
Maria Mercedes Elizalde, Luciana Tadey, Lilia Mammana, Jorge Fabian Quarleri, Rodolfo Hector Campos, Diego Martin Flichman
Summary: This study provides new insights into the biological characteristics of HBV genotypes, showing significant differences in replication capacity and antigen expression among different genotypes. Understanding these differences may help to elucidate the differential role of genotypes in the pathogenesis of HBV.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Immunology
Fenglin Zhao, Xiaoyu Xie, Xu Tan, Hongli Yu, Miaomiao Tian, Huanran Lv, Chengyong Qin, Jianni Qi, Qiang Zhu
Summary: Approximately 250 million people worldwide suffer from chronic Hepatitis B virus infection, leading to significant public health challenges. Despite available vaccines and antiviral drugs, curing chronic hepatitis B remains a distant goal. HBV-encoded proteins, including surface antigen, core antigen, envelope antigen, HBx, and polymerase, play crucial roles in viral persistence and liver pathogenesis, offering potential avenues for new CHB therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Huan Liu, Dexi Liu
Summary: In this study, a novel SARS-CoV-2 viral vector was developed, allowing for investigation by the broader scientific community. The vector transduces target cells in an ACE2-dependent manner, and the incorporation of the VEEV self-amplification mechanism increases gene expression level and extends transgene expression time. Furthermore, the vector has significant applications in neutralizing antibody quantification and antiviral drug testing.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Jie Zhao, Yue-yuan Wang, Wen-ling Chen, Guang-shu Hao, Jian-ping Sun, Qing-fang Shi, Fang Tian, Run-tian Ma
Summary: Developing highly sensitive and selective methods for Cu2+ detection in living systems is of great significance in clinical copper-related disease diagnosis. In this study, a near infrared fluorescent probe CySBH was designed and synthesized for real-time tracking and visualization of Cu2+ in living cells, showing excellent selectivity and sensitivity.
Article
Biochemistry & Molecular Biology
Hsiu-Fang Fan, Wen-Ling Chen, Yan-Zhow Chen, Jian-Wei Huang, Yu-Xin Shen
Summary: This study demonstrates that the abnormal accumulation of alpha-Syn protein in human brain cells is a pathological feature of Parkinson's disease. There are differences in oligomer formation and intracellular interactions between familial Parkinson's disease mutants and C-terminal alpha-Syn truncations.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Environmental Sciences
En Lien, Rama Shanker Sahu, Wen-Ling Chen, Yang-hsin Shih
Summary: Sulfamethoxazole (SMX), a widely used antibiotic, has raised concerns over the development of antibiotic-resistant bacteria in the environment. This study investigated the use of perovskite-type photocatalysts for the removal of SMX. The CaCu3Ti4O7 (CCTO) perovskites showed excellent degradation efficiency under UV-light irradiation, with the addition of NaBr electrolytes further enhancing the removal rate. The study suggests that the inexpensive and environmentally benign CCTO perovskite photocatalyst can be applied for the treatment of emerging contaminants in the future.
Article
Agricultural Engineering
Wenling Chen, Feifei Chen, Shanxing Lai, Menggui Jin, Siyu Xu, Yanfeng Liu, Xing Liang, Ty P. A. Ferre
Summary: This study investigated the distribution and dynamics of cotton fine roots under film-mulched drip irrigation using the minirhizotron technique. The non-uniform distribution of soil moisture and salinity affected the distribution of root length density (RLD). The average RLD in the shallow soil layer decreased due to localized salinity accumulation. A high RLD peak was observed in the 95-100 cm soil layer with high soil moisture content. The production and number of new roots were highest during the initial growth stages. Thinner roots in the deep soil had shorter lifespans than those in shallow soil. The minirhizotron technique was found to be reliable for estimating cotton fine root distribution and dynamics under film-mulched drip irrigation. A cotton root system architecture model could be developed based on these observations for more accurate evaluation of root distribution and dynamics.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Engineering, Environmental
Yi-Jie Li, Chia-Hsien Chuang, Wen-Chih Cheng, Shu-Hwa Chen, Wen-Ling Chen, Yu-Jie Lin, Chung-Yen Lin, Yang-hsin Shih
Summary: This study demonstrates that the indigenous microbial community in agricultural soil in Taiwan can degrade Hexabromocyclododecanes (HBCDs) without the need for additional carbon sources. The researchers identified the metabolic pathways utilized by the soil microbial community and several bacterial taxa that contribute to HBCD biotransformation. The study provides insights into the natural attenuation and remediation mechanisms of HBCDs.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Multidisciplinary Sciences
Abdul Aziz Alimul Hidayat, Wen-Ling Chen, Rahimah Mohd Nor, Musrifatul Uliyah, Fatin Lailatul Badriyah, Masunatul Ubudiyah
Summary: This study aims to determine the factors associated with patient care manager role and the implementation of the clinical pathway among nurses in private hospitals. The results showed a significant correlation between the role of patient care manager and compliance with COVID-19 clinical pathways.
Article
Pharmacology & Pharmacy
Yanyan Zhang, Jiadong Lou, Gareth R. Williams, Yuhan Ye, Dandan Ren, Anhua Shi, Junzi Wu, Wenling Chen, Li-Min Zhu
Summary: In this study, pH-responsive mesoporous silica nanoparticles (MSN) were developed for targeted and synergistic anticancer therapy. The MSNs, functionalized with a histidine-tagged targeting peptide, showed pH-responsive drug release and effectively targeted tumor cells. The presence of an anticancer drug and Cu2+ enhanced the chemotherapeutic effect by generating reactive oxygen species. In vitro and in vivo experiments demonstrated the effective killing of tumor cells and diminished tumor volume without off-target toxicity. The functionalized MSNs show great potential for targeted and synergistic anticancer therapies.
Article
Chemistry, Applied
Wen-Hsin Chang, Yee Soon Ling, Ko-Chih Wang, Fan-Hua Nan, Wen-Ling Chen
Summary: Mislabelling the geographic origin of same-species aquaculture products can be difficult, but this study successfully used untargeted small-molecule fingerprinting to distinguish between Atlantic salmon from Chile and Norway. The technique identified candidate markers associated with feed formulations, but no markers of potential food safety concern were found.
Article
Optics
Wenling Chen, Chao Liu, Yuqi Zou, Zhihe Ren, Yuanzhuo Xiang, Fanchao Meng, Yinsheng Xu, Chong Hou, Sheng Liang, Lueyun Yang, Guangming Tao
Summary: This Letter presents a flexible omnidirectional reflective film made of polymer substrates and two types of chalcogenide glasses for CO2 laser protection. The optimal structure parameters of the device were determined through simulation. The reflector, fabricated by thermal evaporation, achieved a reflectivity of over 78% at 10.6 μm. This flexible reflective film provides a solution for full-angle CO2 laser protection and has potential applications in wearable laser protective clothing.
CHINESE OPTICS LETTERS
(2023)
Review
Chemistry, Inorganic & Nuclear
Huanhuan Zhao, Qingyu Li, Anhua Shi, Ji Cui, Wenling Chen, Junzi Wu
Summary: Nanoparticle-based drug delivery systems have advantages in disease treatment, but their side effects and toxicity are controversial. Plant polysaccharide nanoparticles, as safe and natural biomaterials, have become candidate materials for nano-drug delivery systems due to their excellent biodegradability and biocompatibility. They can improve medicine solubility, reduce toxicity and side effects, and enhance biological targeting of medicines. Therefore, the application of plant polysaccharide nanoparticles in drug delivery systems is of great research value.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Business, Finance
Chien-Chiang Lee, Chih-Wei Wang, Hsin-Yi Hsieh, Wen-Ling Chen
Summary: This paper examines the impact of central bank digital currency volatility on a firm's implied volatility. The sample consists of 2853 listed companies in the United States from 2014 to 2018. The results show that the variation of central bank digital currency has a positive effect on a firm's implied volatility. Additionally, the healthier the firm's conditions, the weaker the relationship between central bank digital currency variation and a firm's implied volatility. Moreover, the positive relationship between central bank digital currency and firm's implied volatility holds true for investment-grade, speculative-grade, and unrated firms. Finally, the use of simultaneous equation models (SEM) confirms the robustness of the results even after excluding endogenous concerns. This research serves as a reminder for corporate managers and provides new implications for policymakers.
RESEARCH IN INTERNATIONAL BUSINESS AND FINANCE
(2023)
Article
Biochemistry & Molecular Biology
Rong Ren, David H. Bremner, Wenling Chen, Anhua Shi, Tong Wang, Ying Wang, Chengji Wang, Junzi Wu, Li-Min Zhu
Summary: This study developed an integrated AI-MPDA@BSA nanocomposite for pancreatic cancer diagnosis and treatment using photoacoustic imaging and cascade nitric oxide release. The nanocomposite exhibited significant anti-cancer effects through the combination of photodynamic therapy and gas therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Wen-Ling Chen, Sih-Yi Yu, Shu-Yen Liu, Sheng-Chi Lin, Tsung-Han Lee
Summary: Livestock wastewater is used for agricultural irrigation to save water and fertilise the soil. This study used high-resolution mass spectrometry to analyze the impact of swine wastewater irrigation on soil and vegetables. The results showed the presence of micropollutants in both soil and vegetables, but no accumulation or contamination was found under the trial conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Astronomy & Astrophysics
Nuo Lei, Zhengzheng Zhou, Qi Zhuang, Wenling Chen, Sergey Chalov, Shuguang Liu, Lisha Gao, Guangtao Dong
Summary: This study evaluates the accuracy of the China Meteorological Forcing Data Set (CMFD) in the Shanghai megacity and improves the accuracy of CMFD precipitation. The performance of CMFD precipitation varies at different time scales, with better accuracy at the monthly scale. The Geographic Differential Analysis (GDA) method is used to calibrate the CMFD precipitation data set, resulting in improved capability, especially at the sub-daily and daily scales. The calibrated CMFD provides reliable precipitation estimates and captures more extreme precipitation events, making it valuable for hydrological and meteorological hazard monitoring and assessment in the Shanghai area.
EARTH AND SPACE SCIENCE
(2023)
Article
Economics
Chien-Chiang Lee, Chih-Wei Wang, Wen-Ling Chen, Pei-Chin Hong
Summary: In this study, we examined the impact of compulsory disclosure regulations on the relationship between Environmental, Social, and Governance (ESG) factors and firm-specific extreme risk. By using a difference-in-difference approach, we found that the negative impact of ESG score on extreme risk becomes more significant after the announcement of compulsory disclosure regulations. Furthermore, our findings also showed that this effect is more pronounced when firms issue green bonds. Subsample tests revealed that the compulsory influence of the government is more evident in firms with high financial transparency and low crash risk. The empirical findings of our study have important policy implications for governments, regulators, and investors.
