Article
Immunology
Xing Yang, Jingfan Zhou, Chengrong Liu, Yafei Qu, Weili Wang, Maggie Z. X. Xiao, Fanxiu Zhu, Zhenshan Liu, Qiming Liang
Summary: The ORF45 protein from Kaposi's sarcoma-associated herpesvirus activates NLRP1 by binding to its Linker1 region using a mechanism distinct from the previously described DPP9-dependent mechanism of NLRP1 activation.
Article
Virology
Qinqin Sun, Fan Wang, Qingyang Chen, Ronit Sarid, Xiaojuan Li, Ersheng Kuang
Summary: The lytic replication of Kaposi's sarcoma-associated herpesvirus (KSHV) is enhanced by ORF45, which upregulates the expression of ATF4 and LAMP3, leading to reprogrammed cellular transcription and translation that supports viral protein production.
JOURNAL OF VIROLOGY
(2022)
Review
Virology
Natalie Atyeo, Bernadett Papp
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) protein ORF45 plays a crucial role in the early and late phases of the viral life cycle, promoting lytic reactivation and proper targeting of the viral capsid. It interacts with host proteins, such as ERK/RSK signaling cascade, and inhibits the host interferon response. Understanding the expression kinetics and interaction partners of ORF45 is significant for studying KSHV biology and gammaherpesvirus infections.
Review
Biochemistry & Molecular Biology
Amanda de Oliveira Lopes, Pedro do Nascimento Marinho, Leticia d'Ambrosio de Souza Medeiros, Vanessa Salete de Paula
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) is a virus containing oncogenes and proteins that play a crucial role in regulating cellular functions and leading to Kaposi's sarcoma. Some of these genes have the potential to be therapeutic targets for Kaposi's sarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Yuan Fang, Wenli Li, Ying Zhang, Chang Zhou, Huanwu Wu, Yiting Zhang, Tao Dai, Jinzhi Wang, Lei Wang, Tongqing Chen, Yulin Zhu, Linding Wang
Summary: The seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV) is high in Gansu, China, especially among certain ethnic groups and syphilis patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Ashish Kumar, Michelle Salemi, Resham Bhullar, Sara Guevara-Plunkett, Yuanzhi Lyu, Kang-Hsin Wang, Chie Izumiya, Mel Campbell, Ken-ichi Nakajima, Yoshihiro Izumiya
Summary: The study used proximity labeling to explore interactions between KSHV viral proteins and cellular proteins, revealing cellular proteins involved in innate immune regulation. The results suggest that selective splicing factors play a role in the regulation of innate immune responses during KSHV replication.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Na Zhang, Han Shi, Miaomiao Yan, Guangliang Liu
Summary: This study reveals that human IFIT5 functions as a negative regulator in the type I IFN signaling pathway by inhibiting the phosphorylation and nuclear translocation of IRF3, therefore impairing the formation of the IRF3-TBK1-IKK epsilon complex and resulting in the degradation of IRF3 and IKK epsilon.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Virology
Lindsey Barrett, Lu Dai, Shanzhi Wang, Zhiqiang Qin
Summary: This article summarizes how KSHV utilizes extracellular vesicles (EVs) to create favorable environments for viral spread and persistence while evading immune responses. EVs play a significant role in the development and function of the immune system.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Qian Chen, Jiangtao Chen, Yuqing Li, Dawei Liu, Yan Zeng, Zheng Tian, Akbar Yunus, Yong Yang, Jie Lu, Xinghua Song, Yan Yuan
Summary: The prevalence of KSHV infection is significantly elevated in Uyghur osteosarcoma patients, with the virus being associated with some osteosarcomas. The study suggests that KSHV infection is a risk factor for osteosarcoma, representing a newly identified viral-associated endemic cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Sophie Grabar, Dominique Costagliola
Summary: An air mattress is a non-breathable sleeping aid commonly used for camping or guests' accommodation.
Article
Biochemistry & Molecular Biology
Congci Yu, Bei Wang, Yue Zhu, Chongyang Zhang, Lili Ren, Xiaobo Lei, Zichun Xiang, Zhuo Zhou, He Huang, Jianwei Wang, Zhendong Zhao
Summary: The transcription regulator ID2 plays a crucial role in immune cell development and differentiation, and it also negatively regulates antiviral innate immune responses. ID2 inhibits the activation of IRF3 by TBK1 and IKK epsilon, leading to a reduction in IFNB1 expression. Knocking out ID2 enhances innate immune responses and suppresses infection by different viruses.
Article
Microbiology
Yuki Iwaisako, Tadashi Watanabe, Mizuki Hanajiri, Yuichi Sekine, Masahiro Fujimuro
Summary: The KSHV ORF7 plays a key role in viral replication by regulating capsid formation, maintaining viral production, and promoting lytic replication through interactions with other terminase components.
Article
Pharmacology & Pharmacy
Gina Cordoba-David, Jorge Garcia-Gimenez, Regiane Cardoso Castelo-Branco, Susana Carrasco, Pablo Cannata, Alberto Ortiz, Adrian M. Ramos
Summary: The study investigates the impact of the type I interferon (TI-IFN) pathway and upstream signaling pathways on tubular injury in kidney disease. The results demonstrate that activation of the TI-IFN pathway and upstream signaling pathways leads to proinflammatory and antiviral responses in tubular cells. Pharmacological inhibition and gene knockdown experiments reveal that inhibition of TBK1/IKK epsilon and IFNAR can protect against tubular injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Tate Tabtieng, Rachel C. Lent, Machika Kaku, Alvaro Monago Sanchez, Marta Maria Gaglia
Summary: Type I interferons play a crucial role in infectious and inflammatory diseases. Viruses have developed strategies to suppress the production of type I interferons, and apoptotic caspases have emerged as important regulators of type I interferon signaling. This study reveals that caspase activity inhibits the DNA sensor cGAS during KSHV infection, blocking the antiviral type I interferon response. These findings provide insights into the mechanisms of viral immune evasion and can inform targeted therapeutic strategies for viral infections.
Article
Biochemistry & Molecular Biology
Yujun Liu, Yuan-Chuan Chen, Bin Yan, Fenyong Liu
Summary: In this study, ribozymes derived from RNase P catalytic RNA were engineered to target the mRNA encoding KSHV RTA. The functional ribozyme F-RTA efficiently sliced the RTA mRNA and suppressed KSHV production and gene expression. This study demonstrates the potential of RNase P ribozymes as a therapy against KSHV.