期刊
JOURNAL OF VIROLOGY
卷 86, 期 7, 页码 4019-4023出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.06871-11
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- NIH from the Southeastern Regional Center of Excellence for Emerging Infections and Biodefense [U54 AI057157]
Humans develop polyclonal, serotype-specific neutralizing antibody responses after dengue virus (DENV) infection. Many mouse antibodies that neutralize DENV bind to the lateral ridge or A strand epitopes on domain III of the viral envelope (EDIII) protein. It has been assumed that these epitopes are also the main target of human neutralizing antibodies. Using recombinant dengue serotype 2 viruses with altered EDIII epitopes, we demonstrate that EDIII epitopes are not the main target of human neutralizing antibody.
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