期刊
JOURNAL OF VIROLOGY
卷 85, 期 10, 页码 5202-5207出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00239-11
关键词
-
类别
资金
- Ministries of Education, Culture, Sports, Science, and Technology
- Ministry of Health Labor and Welfare of Japan
- Contract Research Fund for the Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases
- Ministry of Health
- ERATO
- Global Center of Excellence
- National Institute of Allergy and Infectious Diseases, Public Health Service
- Grants-in-Aid for Scientific Research [22790425] Funding Source: KAKEN
Although H5N1 influenza A viruses can cause systemic infection, their neurotropism and long-term effects on the central nervous system (CNS) are not fully understood. We assessed H5N1viral invasion of the CNS and its long-term effects in a ferret model. An H5N1 virus caused nonsuppurative encephalitis, which lasted for 3 months without neurologic signs. Further, another H5N1 virus caused nonsuppurative vasculitis with brain hemorrhage. Three-dimensional analysis of viral distribution in the brain identified the olfactory system as a major route for brain invasion. The efficient growth of virus in the upper respiratory tract may thus facilitate viral brain invasion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据