Article
Developmental Biology
Bo Wang, Xiaozhi Rong, Yumei Zhou, Yunzhang Liu, Jiqin Sun, Beibei Zhao, Bei Deng, Lei Lu, Ling Lu, Yun Li, Jianfeng Zhou
Summary: This study reveals that EIF4A3 acts as a Wnt inhibitor by interfering with the formation of beta-catenin/Tcf transcription activation complex, playing a crucial role in regulating embryonic development in zebrafish.
Article
Oncology
Shaojian Lin, Weiwei Zhang, Ziwen Shi, Langping Tan, Yue Zhu, Honghao Li, Xinzhi Peng
Summary: The study revealed the transcriptional regulation of LINC01278 by beta-catenin/LEF-1 transcription factor and its negative feedback regulation on beta-catenin signal in papillary thyroid carcinoma (PTC) cells. This negative regulation inhibits downstream target gene expression activated by the Wnt/beta-catenin pathway.
CANCER CELL INTERNATIONAL
(2021)
Review
Cell Biology
Johnny Bou-Rouphael, Beatrice C. Durand
Summary: Since its discovery in the late 90s, Wnt canonical signaling has been shown to play a crucial role in various neural developmental processes, with recent focus on the TCF/LEF-mediated switch from transcriptional activation to repression. Barhl2 is highlighted for its important functions in vertebrate brain development, while TCF/LEF activities in organizer formation and caudal forebrain growth are also discussed. The dysregulation of the Wnt/beta-catenin pathway could lead to tumorigenesis in both embryonic and neural stem cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Antonio Herrera, Anghara Menendez, Andrea Ochoa, Lidia Bardia, Julien Colombelli, Sebastian Pons
Summary: In the developing spinal cord, neurogenesis stimulates Tcf-dependent transcription through the nuclear accumulation of beta-catenin, independently of Wnt signaling. This process regulates genes involved in contralateral axon growth, including axon guidance and adhesion. These findings demonstrate the importance of Wnt-independent Tcf/beta-catenin regulation in controlling commissural axon growth in the chick spinal cord.
Article
Multidisciplinary Sciences
Stephen Arnovitz, Priya Mathur, Melissa Tracy, Azam Mohsin, Soumi Mondal, Jasmin Quandt, Kyle M. Hernandez, Khashayarsha Khazaie, Marei Dose, Akinola Olumide Emmanuel, Fotini Gounari
Summary: This study reveals that aberrant activation of beta-catenin in thymocytes contributes to leukemias by promoting translocations and transformation. Lymphomas resembling T-ALL are sensitive to PARP inhibitors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Gesa Richter, Tianshu Gui, Benjamin Bourgeois, Chintan N. Koyani, Peter Ulz, Ellen Heitzer, Dirk von Lewinski, Boudewijn M. T. Burgering, Ernst Malle, Tobias Madl
Summary: The research identified the Wnt signaling pathway as a key target of FOXP2-dependent transcriptional regulation, showing that beta-catenin plays a role in regulating FOXP2 transcriptional activity. The study used nuclear magnetic resonance spectroscopy to uncover the molecular details of the interactions between beta-catenin and FOXP2, demonstrating the importance of the FOXP2 alpha-helical motif in transcriptional regulation.
Article
Cell Biology
Yong Ji, Yiqian Liu, Changchun Sun, Lijiang Yu, Zhao Wang, Xu Du, Wu Yang, Chenggong Zhang, Chunmu Tao, Jianjiang Wang, Xi Yang, Sun Di, Yufeng Huang
Summary: Mutations in the Wnt/beta-catenin signaling pathway upstream lead to abnormal activation in colon cancer, and ADCK1 plays a crucial role in promoting cancer progression by interacting with TCF4 to activate the beta-catenin/TCF pathway. This research identifies potential therapeutic targets for colon cancer treatment.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Janna Froehlich, Katja Rose, Andreas Hecht
Summary: The unrestrained transcriptional activity of beta-CATENIN and its binding partner TCF7L2 is often found in colorectal tumor initiation and is considered to be an oncogenic driver throughout intestinal carcinogenesis. However, the TCF7L2 gene carries inactivating mutations in some colorectal tumors and is non-essential in colorectal cancer cell lines. This study shows that CRC cells can become independent of TCF7L2 through compensation by other TCF/LEF family members, or they can lose their dependence on beta-CATENIN/TCF7L2-driven gene expression completely. The findings have important implications for evaluating beta-CATENIN and TCF7L2 as potential drug targets.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Shengliang Gu, Fahui Liu, Xueheng Xie, Meng Ding, Zhen Wang, Xiaoyan Xing, Tianbao Xiao, Xiaobo Sun
Summary: The study aimed to investigate the biological functions and prognostic value of the LEF-1-mediated Wnt/β-catenin pathway in colon cancer (CC). Beta-sitosterol was found to effectively suppress CC cell growth and migration by down-regulating LEF-1 and disrupting the Wnt/β-catenin pathway. These results suggest that beta-sitosterol can be used as a potential treatment for CC by targeting LEF-1.
CELLULAR SIGNALLING
(2023)
Article
Cell Biology
Heidi Espadas-Alvarez, Jacqueline Martinez-Rendon, Isabel Larre, Arturo Matamoros-Volante, Tatiana Romero-Garcia, Tamara Rosenbaum, Angelica Rueda, Refugio Garcia-Villegas
Summary: TRPV4 channel functions in the nucleus, inhibiting the transcriptional activity of beta-catenin through a direct interaction, and may regulate differentiation in various cellular contexts.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Food Science & Technology
Jing Li, Xiaoling Lyu, Pan Wang, Bao Ting Zhu
Summary: This study found that bilberry anthocyanins have a modulating effect on the pathogenesis of Alzheimer's disease. They reduce amyloid plaque load and beta-amyloid 1-42 levels, improve mitochondrial morphology, and decrease NO and ROS levels. In HT22 cells, bilberry anthocyanins also protect against A beta 42-induced cytotoxicity by reducing ROS levels and restoring mitochondrial homeostasis, partly through the upregulation of Mfn2. These findings suggest that bilberry anthocyanins can protect against the development of Alzheimer's disease by restoring mitochondrial homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Multidisciplinary Sciences
Abhishek Sinha, Vinson B. Fan, Aravinda-Bharathi Ramakrishnan, Nicole Engelhardt, Jennifer Kennell, Ken M. Cadigan
Summary: SOX9 promotes turnover of β-catenin independently of the destruction complex and proteasome in mammalian cell culture. This requires the activation of MAML2, which acts as a coactivator for SOX9 in antagonizing the Wnt/β-catenin pathway. This newly identified pathway provides a parallel mechanism for restricting Wnt/β-catenin signaling.
Article
Oncology
Hung-Wen Tsai, Shu-Wen Cheng, Chou-Cheng Chen, I-Wen Chen, Chung-Liang Ho
Summary: In this study, a combined bioinformatics and experimental approach was used to identify potential target genes of the Wnt/beta-catenin signaling pathway. It was found that RMI2 is a new target gene of this pathway and that it promotes epithelial-mesenchymal transition markers, hepatocellular carcinoma cell invasion, and metastasis. These findings suggest that RMI2 could be a potential target for preventing or mitigating the progression of hepatocellular carcinoma.
Review
Chemistry, Medicinal
Zhen Wang, Zilu Li, Haitao Ji
Summary: Aberrant activation of the Wnt/beta-catenin signaling pathway is associated with cancer, and direct targeting of beta-catenin is a promising strategy but challenging. Research has identified potential small-molecule binding sites and summarized bioactive small molecules that target beta-catenin directly.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Integrative & Complementary Medicine
Li Yue-jun, Liao Lin-li, Liu Pei, Tang Ping, Wang Hong, Peng Qing-hua
Summary: SJZD inhibits the development and proliferation of gastric cancer stem cells by attenuating the transcriptional activity of beta-catenin.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Meeting Abstract
Oncology
Xiaohui Tan, Yebo Fu, Liang Chen, Shejuan An, Woojin Lee, Yinglei Lai, Katayoon Rezaei, Sana Tabbara, Christine B. Teal, Yan-gao Man, Robert Siegel, Rachel F. Brem, Sidney W. Fu
Article
Biochemistry & Molecular Biology
Justin E. Wilson, Alex S. Petrucelli, Liang Chen, A. Alicia Koblansky, Agnieszka D. Truax, Yoshitaka Oyama, Arlin B. Rogers, W. June Brickey, Yuli Wang, Monika Schneider, Marcus Muehlbauer, Wei-Chun Chou, Brianne R. Barker, Christian Jobin, Nancy L. Allbritton, Dale A. Ramsden, Beckley K. Davis, Jenny P. Y. Ting
Article
Oncology
Xiaohui Tan, Yebo Fu, Liang Chen, Woojin Lee, Yinglei Lai, Katayoon Rezaei, Sana Tabbara, Patricia Latham, Christine B. Teal, Yan-Gao Man, Robert S. Siegel, Rachel F. Brem, Sidney W. Fu
Article
Oncology
Rongrong Liu, Agnieszka D. Truax, Liang Chen, Peizhen Hu, Zengshan Li, Jun Chen, Chaojun Song, Lihua Chen, Jenny Pan-Yun Ting
Meeting Abstract
Oncology
Liang Chen, Meng Wang, Jin Peng, Christine Teal, Michael Stamatakos, Timothy McCaffrey, Sidney W. Fu
Article
Medicine, Research & Experimental
Amandine I. Garcia, Monique Buisson, Pascale Bertrand, Ruth Rimokh, Etienne Rouleau, Bernard S. Lopez, Rosette Lidereau, Ivan Mikaelian, Sylvie Mazoyer
EMBO MOLECULAR MEDICINE
(2011)
Article
Biochemistry & Molecular Biology
Timothy A. McCaffrey, Constantine Tziros, Jannet Lewis, Richard Katz, Robert Siegel, William Weglicki, Jay Kramer, Tong Mak, Ian Toma, Liang Chen, Elizabeth Benas, Alexander Lowitt, Shruti Rao, Linda Witkin, Yi Lian, Yinglei Lai, Zhaoqing Yang, Sidney W. Fu
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2013)
Article
Multidisciplinary Sciences
Liang Chen, Youhuai Li, Yebo Fu, Jin Peng, Meng-Hsuan Mo, Michael Stamatakos, Christine B. Teal, Rachel F. Brem, Alexander Stojadinovic, Michael Grinkemeyer, Timothy A. McCaffrey, Yan-Gao Man, Sidney W. Fu
Review
Oncology
Sidney W. Fu, Liang Chen, Yan-gao Man
Review
Oncology
Meng-Hsuan Mo, Liang Chen, Yebo Fu, Wendy Wang, Sidney W. Fu
Article
Oncology
Fengmei Shen, Meng-Hsuan Mo, Liang Chen, Shejuan An, Xiaohui Tan, Yebo Fu, Katayoon Rezaei, Zuoren Wang, Lin Zhang, Sidney W. Fu