Binding of Anti-Membrane-Proximal gp41 Monoclonal Antibodies to CD4-Liganded and -Unliganded Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Virions

Anti-HIV-1 antibodies 2F5 and 4E10 interact differently with lipids to bind their epitopes

(2011) Henri G Franquelim et al.   AIDS

Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges

(2011) Morgane Bomsel et al.   IMMUNITY

MPER-specific antibodies induce gp120 shedding and irreversibly neutralize HIV-1

(2011) Claudia R. Ruprecht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enzyme Digests Eliminate Nonfunctional Env from HIV-1 Particle Surfaces, Leaving Native Env Trimers Intact and Viral Infectivity Unaffected

(2011) E. T. Crooks et al.   JOURNAL OF VIROLOGY

HIV Type 1 Env Precursor Cleavage State Affects Recognition by Both Neutralizing and Nonneutralizing gp41 Antibodies

(2010) Bimal K. Chakrabarti et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Synthesis and analysis of the membrane proximal external region epitopes of HIV-1

(2010) Sampat Ingale et al.   JOURNAL OF PEPTIDE SCIENCE

Ablation of the Complementarity-Determining Region H3 Apex of the Anti-HIV-1 Broadly Neutralizing Antibody 2F5 Abrogates Neutralizing Capacity without Affecting Core Epitope Binding

(2010) J. P. Julien et al.   JOURNAL OF VIROLOGY

In-Solution Virus Capture Assay Helps Deconstruct Heterogeneous Antibody Recognition of Human Immunodeficiency Virus Type 1

(2010) D. P. Leaman et al.   JOURNAL OF VIROLOGY

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

(2010) Hugo Mouquet et al.   NATURE

Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution

(2010) X. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions

(2010) E. M. Scherer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Importance of Antibody Isotype in HIV-1 Virus Capture Assay and in TZM-bl Neutralization

(2010) Kristina K. Peachman et al.   VIRAL IMMUNOLOGY

The effect of sCD4 on the binding and accessibility of HIV-1 gp41 MPER epitopes to human monoclonal antibodies

(2010) Kristina K. Peachman et al.   VIROLOGY

4E10 and 2F5 monoclonal antibodies: binding specificities to phospholipids, tolerance, and clinical safety issues

(2009) Carl R Alving   AIDS

Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes

(2009) Gary R Matyas et al.   AIDS

Distinct Mechanisms of Lipid Bilayer Perturbation Induced by Peptides Derived from the Membrane-Proximal External Region of HIV-1 gp41

(2009) Beatriz Apellániz et al.   BIOCHEMISTRY

Interactions of HIV-1 Antibodies 2F5 and 4E10 with a gp41 Epitope Prebound to Host and Viral Membrane Model Systems

(2009) Ana S. Veiga et al.   CHEMBIOCHEM

Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design Implications

(2009) S. Bryson et al.   JOURNAL OF VIROLOGY

Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIVBa-L

(2009) A. J. Hessell et al.   JOURNAL OF VIROLOGY

Antibody Specificities Associated with Neutralization Breadth in Plasma from Human Immunodeficiency Virus Type 1 Subtype C-Infected Blood Donors

(2009) E. S. Gray et al.   JOURNAL OF VIROLOGY

In Vivo gp41 Antibodies Targeting the 2F5 Monoclonal Antibody Epitope Mediate Human Immunodeficiency Virus Type 1 Neutralization Breadth

(2009) X. Shen et al.   JOURNAL OF VIROLOGY

Stable Docking of Neutralizing Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Monoclonal Antibodies 2F5 and 4E10 Is Dependent on the Membrane Immersion Depth of Their Epitope Regions

(2009) S. M. Dennison et al.   JOURNAL OF VIROLOGY

A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies

(2009) R. Pejchal et al.   JOURNAL OF VIROLOGY

Broad Neutralization of Human Immunodeficiency Virus Type 1 Mediated by Plasma Antibodies against the gp41 Membrane Proximal External Region

(2009) E. S. Gray et al.   JOURNAL OF VIROLOGY

Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface

(2009) L. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10

(2009) J. S. Klein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of HIV membrane in neutralization by two broadly neutralizing antibodies

(2009) S. M. Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1

(2009) Yun (Kenneth) Kang et al.   VACCINE

Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1

(2008) Gary R. Matyas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural Details of HIV-1 Recognition by the Broadly Neutralizing Monoclonal Antibody 2F5: Epitope Conformation, Antigen-Recognition Loop Mobility, and Anion-Binding Site

(2008) Jean-Philippe Julien et al.   JOURNAL OF MOLECULAR BIOLOGY

Factors Associated with the Development of Cross-Reactive Neutralizing Antibodies during Human Immunodeficiency Virus Type 1 Infection

(2008) D. N. Sather et al.   JOURNAL OF VIROLOGY

The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 4E10 Monoclonal Antibody Is Better Adapted to Membrane-Bound Epitope Recognition and Blocking than 2F5

(2008) N. Huarte et al.   JOURNAL OF VIROLOGY

Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C

(2008) J. M. Binley et al.   JOURNAL OF VIROLOGY

Sequestering of the Prehairpin Intermediate of gp41 by Peptide N36Mut(e,g) Potentiates the Human Immunodeficiency Virus Type 1 Neutralizing Activity of Monoclonal Antibodies Directed against the N-Terminal Helical Repeat of gp41

(2008) E. Gustchina et al.   JOURNAL OF VIROLOGY

Importance of the Membrane-Perturbing Properties of the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 gp41 to Viral Fusion

(2008) S. A. Vishwanathan et al.   JOURNAL OF VIROLOGY

Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia

(2008) G. D. Tomaras et al.   JOURNAL OF VIROLOGY

The Membrane-Proximal External Region of the Human Immunodeficiency Virus Type 1 Envelope: Dominant Site of Antibody Neutralization and Target for Vaccine Design

(2008) M. Montero et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Molecular architecture of native HIV-1 gp120 trimers

(2008) Jun Liu et al.   NATURE

A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

(2008) G. Frey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics

(2008) Josh D. Nelson et al.   VIROLOGY