期刊
JOURNAL OF VIROLOGY
卷 85, 期 22, 页码 12067-12072出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.05559-11
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资金
- NIH, National Institute of Allergy and Infectious Diseases (NIAID)
Cleavage of the flavivirus prM protein by a cellular furin-like protease is a hallmark of virion maturation. While this cleavage is a required step in the viral life cycle, it can be inefficient. Virions that retain uncleaved prM may be infectious. We investigated whether cleavage by furin of prM on partially mature West Nile virus (WNV) during virus entry contributes to infectivity. Using quantitative assays of WNV infection, we found that virions incorporating considerable amounts of uncleaved prM protein were insensitive to treatment of cells with a potent inhibitor of furin activity. Thus, partially mature WNV does not require furin-like proteases for infectivity.
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