Review
Biochemistry & Molecular Biology
Malte Kellermann, Felix Scharte, Michael Hensel
Summary: Pathogenic intracellular microorganisms manipulate host cells to create niches for survival and replication. This review focuses on the manipulation of organelle compartments by pathogens and highlights the specific interactions of different pathogens with host cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jhalak Singhal, Evanka Madan, Ayushi Chaurasiya, Pallavi Srivastava, Niharika Singh, Shikha Kaushik, Amandeep Kaur Kahlon, Mukesh Kumar Maurya, Manisha Marothia, Prerna Joshi, Anand Ranganathan, Shailja Singh
Summary: SUMOylation is involved in the infection process of Leishmania donovani by hijacking the host immune responses and facilitating host autophagy. Targeting the SUMOylation pathway may provide a potential therapeutic intervention for leishmaniasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Virology
Xing Zhang, Yan Zhang, Wen Liu, Bing Luo
Summary: Protein post-translational modifications (PTMs) are reversible processes that regulate the function of target proteins without altering their sequences. EBV, a ubiquitous herpesvirus, can manipulate host ubiquitination, SUMOylation, and phosphorylation to establish a latent infection or favor viral replication and pathogenesis. Understanding the mechanisms by which EBV products manipulate host PTMs is crucial for exploring new therapeutic strategies against EBV-associated diseases.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Massimiliano Baldassarre, Virtu Solano-Collado, Arda Balci, Rosa A. Colamarino, Ivy M. Dambuza, Delyth M. Reid, Heather M. Wilson, Gordon D. Brown, Subhankar Mukhopadhyay, Gordon Dougan, Stefania Spano
Summary: The Rab32/BLOC-3 pathway in macrophages is a novel and crucial host immune defense mechanism that controls bacterial and fungal infection independently of other known antimicrobial mechanisms, helping mammals protect against various pathogens.
Review
Microbiology
Nora Kostow, Matthew D. Welch
Summary: Manipulation of host cell plasma membrane by intracellular bacterial pathogens is crucial for their infection. Bacteria employ various strategies to target and influence the composition and shape of the plasma membrane, taking advantage of pathways such as signal transduction, endocytosis, and exocytosis. Further investigation into the contributions of bacterial and host factors to plasma membrane manipulation will provide valuable insights into pathogenesis and fundamental principles of plasma membrane biology.
CURRENT OPINION IN MICROBIOLOGY
(2023)
Review
Immunology
Oliver Harschnitz, Lorenz Studer
Summary: The review explains the use of human pluripotent stem cell technology in studying antiviral immunity in the central nervous system. This technology offers a unique opportunity for researching new therapies and mechanisms of CNS viral infections, including those associated with SARS-CoV-2. The advancements in this technology allow for studying host-virus interactions and complex disease mechanisms in disease-relevant cells of the human CNS.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Microbiology
Huifang Wang, Zhuoyue Lu, Nemat O. Keyhani, Juan Deng, Xin Zhao, Shuaishuai Huang, Zhibing Luo, Kai Jin, Yongjun Zhang
Summary: Fungal pathogen Beauveria bassiana expresses an endo-beta-1,3-glucanase (BbEng1) that helps the fungus evade host immune recognition and defense by remodeling the cell wall pathogen associated molecular patterns (PAMPs). Loss of BbEng1 increases cell wall glucan levels and overexpression of BbEng1 decreases cell wall glucan levels, leading to increased virulence.
Review
Cell Biology
T. K. Sajeev, Garima Joshi, Pooja Arya, Vibhuti Mahajan, Akanksha Chaturvedi, Ram Kumar Mishra
Summary: Pathogens constantly challenge the survival of host species, prompting orchestrated defense responses by the immune system. Post-translational modifications, including ubiquitination and SUMOylation, play crucial roles in regulating immune responses. SUMOs modify target proteins both covalently and non-covalently, impacting their localization, interactions, functions, and stability in the immune system. The interplay of SUMOylation and immune signaling pathways is complex and essential for maintaining a robust immune network in hosts and presents opportunities for novel therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Hafsa Qadri, Munazah Fazal Qureshi, Manzoor Ahmad Mir, Abdul Haseeb Shah
Summary: The incidence of human fungal infections is increasing due to the expansion of the immunocompromised patient population. Fungal pathogens deploy multiple resistance strategies to tackle the effect of antifungal agents, with glucose playing a central role in influencing pathogenicity and virulence traits.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Immunology
Suborno Jati, Soham Sengupta, Malini Sen
Summary: The study found that the Wnt5A signaling pathway plays different roles in handling pathogenic and non-pathogenic infections, with a potentially crucial role in regulating intracellular actin organization of bacteria.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Yolanda Rivera-Cuevas, Vern B. Carruthers
Summary: Intracellular pathogens interact with the ESCRT machinery of their hosts using short linear amino acid motifs similar to those used by ESCRTs to assemble on target membranes. They exploit this molecular mimicry to preserve their intracellular niche, gain resources, or egress from infected cells.
Article
Multidisciplinary Sciences
Mouhita Humayun, Jose M. Ayuso, Keon Young Park, Bruno Martorelli Di Genova, Melissa C. Skala, Sheena C. Kerr, Laura J. Knoll, David J. Beebe
Summary: The development of a human microphysiological system of intestinal tissue provides a new method for studying the interactions between parasites and immune cells, which is of great importance for understanding human parasitic infections.
Article
Biochemistry & Molecular Biology
Apollo Stacy, Vinicius Andrade-Oliveira, John A. McCulloch, Benedikt Hild, Ji Hoon Oh, P. Juliana Perez-Chaparro, Choon K. Sim, Ai Ing Lim, Verena M. Link, Michel Enamorado, Giorgio Trinchieri, Julia A. Segre, Barbara Rehermann, Yasmine Belkaid
Summary: The research shows that gut microbiota from previously infected hosts have enhanced resistance to infection, associated with altered bile acid metabolism and expansion of taxa that utilize taurine. The supply of exogenous taurine alone can induce this alteration and enhance resistance. Mechanistically, taurine potentiates the microbiota's production of sulfide, inhibiting cellular respiration and promoting resistance to pathogen invasion.
Article
Biochemistry & Molecular Biology
Rui Qin, Lara K. Mahal
Summary: Recent discoveries have shed light on the roles of glycans in infectious diseases, particularly in the host glycome response to infection. While the functions and dynamics of host glycans during infection are still not fully understood, new findings have provided insights into the mechanisms and implications of these interactions in host immunity.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2021)
Review
Neurosciences
Fergan Imbert, Dianne Langford
Summary: The conjugation of small ubiquitin-like modifier (SUMO) proteins to substrates is a crucial post-translational modification that regulates protein activity and subcellular localization, playing a key role in viral infections. Viruses manipulate the SUMO pathway to modify host proteins, impacting host innate immunity and viral replication, particularly in latent infections like HIV-1.
JOURNAL OF NEUROVIROLOGY
(2021)
Article
Virology
Carolin Buerck, Andreas Mund, Julia Berscheminski, Lisa Kieweg, Sarah Muencheberg, Thomas Dobner, Sabrina Schreiner
JOURNAL OF VIROLOGY
(2016)
Article
Biochemistry & Molecular Biology
J. Berscheminski, J. Brun, T. Speiseder, P. Wimmer, W. H. Ip, M. Terzic, T. Dobner, S. Schreiner
Article
Biochemistry & Molecular Biology
P. Wimmer, J. Berscheminski, P. Blanchette, P. Groitl, P. E. Branton, R. T. Hay, T. Dobner, S. Schreiner
Review
Virology
Peter Wimmer, Sabrina Schreiner
Article
Microbiology
Frederic Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette
Article
Microbiology
Frederic Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette
Article
Biotechnology & Applied Microbiology
Friederike Neumann, Manja Czech-Sioli, Thomas Dobner, Adam Grundhoff, Sabrina Schreiner, Nicole Fischer
JOURNAL OF GENERAL VIROLOGY
(2016)
Article
Virology
Nora Freudenberger, Tina Meyer, Peter Groitl, Thomas Dobner, Sabrina Schreiner
JOURNAL OF VIROLOGY
(2018)
Article
Virology
Raviteja Inturi, Kwangchol Mun, Katrin Singethan, Sabrina Schreiner, Tanel Punga
JOURNAL OF VIROLOGY
(2018)
Review
Virology
Sabrina Schreiner, Michael Nassal
Article
Virology
Sarah Muencheberg, Ron T. Hay, Wing H. Ip, Tina Meyer, Christina Weiss, Jara Brenke, Sawinee Masser, Kamyar Hadian, Thomas Dobner, Sabrina Schreiner
JOURNAL OF VIROLOGY
(2018)
Article
Virology
Anna Reichel, Anne-Charlotte Stilp, Myriam Scherer, Nina Reuter, Soeren Lukassen, Bahram Kasmapour, Sabrina Schreiner, Luka Cicin-Sain, Andreas Winterpacht, Thomas Stamminger
JOURNAL OF VIROLOGY
(2018)
Article
Chemistry, Multidisciplinary
Samuel Hofmann, Julia Mai, Sawinee Masser, Peter Groitl, Alexander Herrmann, Thomas Sternsdorf, Ruth Brack-Werner, Sabrina Schreiner
Article
Microbiology
Lilian Goettig, Christina Weiss, Miona Stubbe, Lisa Hanrieder, Samuel Hofmann, Alessandro Grodziecki, Daniela Stadler, Arnaud Carpentier, Ulrike Protzer, Sabrina Schreiner
Summary: Apobec3A is upregulated during HAdV infection and its stabilization is mediated by viral proteins E1B-55K and E4orf6, leading to limited HAdV replication through a deaminase-dependent mechanism. Silencing Apobec3A enhances adenoviral replication. HAdV triggers Apobec3A dimerization and increases its activity to repress the virus by disrupting viral replication centers.
Article
Biology
Peter A. C. Wing, Tamara Davenne, Jochen Wettengel, Alvina G. Lai, Xiaodong Zhuang, Anindita Chakraborty, Valentina D'Arienzo, Catharina Kramer, Chunkyu Ko, James M. Harris, Sabrina Schreiner, Martin Higgs, Stephanie Roessler, Joanna L. Parish, Ulrike Protzer, Peter Balfe, Jan Rehwinkel, Jane A. McKeating
LIFE SCIENCE ALLIANCE
(2019)