Review
Biochemistry & Molecular Biology
Amanda de Oliveira Lopes, Pedro do Nascimento Marinho, Leticia d'Ambrosio de Souza Medeiros, Vanessa Salete de Paula
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) is a virus containing oncogenes and proteins that play a crucial role in regulating cellular functions and leading to Kaposi's sarcoma. Some of these genes have the potential to be therapeutic targets for Kaposi's sarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Yuan Fang, Wenli Li, Ying Zhang, Chang Zhou, Huanwu Wu, Yiting Zhang, Tao Dai, Jinzhi Wang, Lei Wang, Tongqing Chen, Yulin Zhu, Linding Wang
Summary: The seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV) is high in Gansu, China, especially among certain ethnic groups and syphilis patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Microbiology
Sydney J. Bennett, Dicle Yalcin, Sara R. Privatt, Owen Ngalamika, Salum J. Lidenge, John T. West, Charles Wood
Summary: This study presents the first high-resolution epitope map of the latency-associated nuclear antigen (LANA) in Kaposi sarcoma (KS) patients and asymptomatic KSHV-infected individuals using high-throughput phage display (VirScan). The results show that a 24-amino acid peptide on LANA is highly antigenic in both groups, regardless of co-infection with human immunodeficiency virus (HIV). HIV co-infection is associated with a lower response to this epitope in KS patients, but has little to no effect in the absence of cancer. Further studies on this identified epitope may have therapeutic, diagnostic, or viral decoy potential. The application of these findings could be important for designing effective vaccines and therapeutics for KSHV infection and prevention of progression to KS.
Review
Virology
Lindsey Barrett, Lu Dai, Shanzhi Wang, Zhiqiang Qin
Summary: This article summarizes how KSHV utilizes extracellular vesicles (EVs) to create favorable environments for viral spread and persistence while evading immune responses. EVs play a significant role in the development and function of the immune system.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Qian Chen, Jiangtao Chen, Yuqing Li, Dawei Liu, Yan Zeng, Zheng Tian, Akbar Yunus, Yong Yang, Jie Lu, Xinghua Song, Yan Yuan
Summary: The prevalence of KSHV infection is significantly elevated in Uyghur osteosarcoma patients, with the virus being associated with some osteosarcomas. The study suggests that KSHV infection is a risk factor for osteosarcoma, representing a newly identified viral-associated endemic cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Sophie Grabar, Dominique Costagliola
Summary: An air mattress is a non-breathable sleeping aid commonly used for camping or guests' accommodation.
Article
Microbiology
Yuki Iwaisako, Tadashi Watanabe, Mizuki Hanajiri, Yuichi Sekine, Masahiro Fujimuro
Summary: The KSHV ORF7 plays a key role in viral replication by regulating capsid formation, maintaining viral production, and promoting lytic replication through interactions with other terminase components.
Review
Microbiology
Floriane Lagadec, Vincent Parissi, Paul Lesbats
Summary: The H2A-H2B acidic patch has been identified as a key element for nucleosome recognition and chromatin structure regulation. The folding of chromatin arrays relies on the interaction between the histone H4 tail and the adjacent nucleosome acidic patch. Cellular factors and viral proteins have been found to bind to the acidic patch, influencing the chromatin state and potentially affecting viral infections.
Article
Microbiology
Tate Tabtieng, Rachel C. Lent, Machika Kaku, Alvaro Monago Sanchez, Marta Maria Gaglia
Summary: Type I interferons play a crucial role in infectious and inflammatory diseases. Viruses have developed strategies to suppress the production of type I interferons, and apoptotic caspases have emerged as important regulators of type I interferon signaling. This study reveals that caspase activity inhibits the DNA sensor cGAS during KSHV infection, blocking the antiviral type I interferon response. These findings provide insights into the mechanisms of viral immune evasion and can inform targeted therapeutic strategies for viral infections.
Article
Microbiology
Brian F. Niemeyer, Bridget Sanford, Joy E. Gibson, Jennifer N. Berger, Lauren M. Oko, Eva Medina, Eric T. Clambey, Linda F. van Dyk
Summary: Research has shown that the viral cyclin plays a critical role in promoting the transition of gammaherpesviruses from latency to active infection by affecting the frequency of LANA gene expression. Disruption of the viral cyclin significantly reduces the expression frequency of the LANA gene, without affecting the distribution of infected cells, but is crucial for reactivation.
Article
Biochemistry & Molecular Biology
Yujun Liu, Yuan-Chuan Chen, Bin Yan, Fenyong Liu
Summary: In this study, ribozymes derived from RNase P catalytic RNA were engineered to target the mRNA encoding KSHV RTA. The functional ribozyme F-RTA efficiently sliced the RTA mRNA and suppressed KSHV production and gene expression. This study demonstrates the potential of RNase P ribozymes as a therapy against KSHV.
Article
Infectious Diseases
Jinchuan Shi, Gaoxiang Ying, Zhongdong Zhang
Summary: In the treatment of AIDS patients with Kaposi's sarcoma, the reconstitution of immune function and consecutive chemotherapy with doxorubicin liposome are crucial. Early recognition and histopathological verification of general symptoms such as thrombocytopenia and hemorrhagic purple papules in AIDS patients are necessary to achieve early diagnosis of KS and timely clinical intervention.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Chunhong Di, Guoxia Zheng, Yunheng Zhang, Enyu Tong, Yanli Ren, Yu Hong, Yang Song, Rong Chen, Xiaohua Tan, Lei Yang
Summary: The recombination signal binding protein for immunoglobulin kappa J region (RBPJ) plays a dual role in Kaposi's sarcoma-associated herpesvirus (KSHV) replication. Its interaction with replication and transcription activator (RTA) is essential for lytic replication, while the interaction with latency-associated nuclear antigen (LANA) facilitates latent infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Vickie A. Marshall, Nicholas C. Fisher, Charles A. Goodman, Elena M. Cornejo Castro, Isabella Liu, Sirish Khanal, Benjamin M. Holdridge, Abigail L. Thorpe, Nazzarena Labo, Kristen B. Stolka, Jennifer J. Hemingway-Foday, Mahamat Abassora, Paul N'Dom, Jennifer S. Smith, Neneh Sallah, Anne L. Palser, Paul Kellam, Brandon F. Keele, Denise Whitby
Summary: In sub-Saharan Africa, the endemicity of Kaposi's sarcoma-associated herpesvirus (KSHV) and the resulting Kaposi's sarcoma (KS) pose significant public health challenges. This study conducted near full-length KSHV genome sequence analysis on samples from individuals in Cameroon, revealing unique polymorphisms, genotypic diversity, and evidence of recombination. However, no correlation was found between viral sequence variations and disease. This is the first study to systematically compare near full-length KSHV genome sequences between KS cases and controls in the same region.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Virology
Xin Zhang, Qiwen Fang, Sibo Zhu, Xuefu Wu, Huangbo Yuan, Zhenqiu Liu, Yiyun Xu, Tao Chen, Yan Zeng, Tiejun Zhang
Summary: This study aimed to investigate the genetic and environmental predisposing factors for KSHV infection among the Uygur population in Xinjiang, China. The findings revealed that sweet-food preference, coronary heart disease, and genetic variation in HLA-DQB1*06:09 were strongly associated with KSHV infection.
JOURNAL OF MEDICAL VIROLOGY
(2022)