Article
Microbiology
Ewa Chrostek, Nelson Martins, Marta S. Marialva, Luis Teixeira
Summary: Temperature modulates the antiviral protection conferred by Wolbachia in Drosophila, with higher temperatures leading to more lethal viruses and reduced Wolbachia protection. Host developmental temperature is a determinant of the level of antiviral protection provided by Wolbachia.
Article
Plant Sciences
Francisco J. de Lamo, Staf B. Spijkers, Frank L. W. Takken
Summary: Fusarium oxysporum can cause disease or provide biological control, utilizing different mechanisms to reduce susceptibility of the host to subsequent infections.
Article
Microbiology
Yuta Hikichi, Rachel Van Duyne, Phuong Pham, Jennifer L. Groebner, Ann Wiegand, John W. Mellors, Mary F. Kearney, Eric O. Freed
Summary: The presence of mutations in the HIV-1 envelope glycoprotein (Env) can lead to reduced susceptibility to multiple classes of antiretroviral drugs (ARVs) and may contribute to virological failure in patients. The accumulation of Env mutations in individuals failing integrase inhibitor therapy suggests a possible mechanism for drug resistance development without mutations in target genes. Understanding how Env mutations affect drug resistance may influence therapeutic strategies for ARV-treated patients.
Article
Plant Sciences
Ying Wu, W. Kyle Sexton, Qiong Zhang, David Bloodgood, Yan Wu, Caroline Hooks, Frank Coker, Andrea Vasquez, Cheng- Wei, Shunyuan Xiao
Summary: This study reveals that the abaxial surface of Arabidopsis leaves has enhanced immunity against powdery mildew, which is attributed to the EDS1/PAD4- and PEN2/PEN3-dependent defenses. These defense mechanisms may also play a role in conferring adaxial immunity against powdery mildew in other plant species.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Cell Biology
Pavlo A. Nesterenko, Jami McLaughlin, Brandon L. Tsai, Giselle Burton Sojo, Donghui Cheng, Daniel Zhao, Zhiyuan Mao, Nathanael J. Bangayan, Matthew B. Obusan, Yapeng Su, Rachel H. Ng, William Chour, Jingyi Xie, Yan-Ruide Li, Derek Lee, Miyako Noguchi, Camille Carmona, John W. Phillips, Jocelyn T. Kim, Lili Yang, James R. Heath, Paul C. Boutros, Owen N. Witte
Summary: Cross-reactivity and direct killing of target cells by SARS-CoV-2-specific CD8(+) T cells are not well studied. Isolating and overexpressing T cell receptors (TCRs) in allogeneic cells allows for extensive profiling of T cell reactivity. The discovery that some CD8(+) T cells can recognize multiple coronaviruses may help define vaccine epitopes that induce long-term immunity.
Article
Zoology
Mao-Sen Ye, Jin-Yan Zhang, Dan-Dan Yu, Min Xu, Ling Xu, Long-Bao Lv, Qi-Yun Zhu, Yu Fan, Yong-Gang Yao
Summary: The Chinese tree shrew is becoming an important experimental animal in biomedical research. By collecting and analyzing RNA data, researchers have identified thousands of new coding and non-coding genes in the tree shrew genome. Comparative analysis showed that tree shrews are more similar to primates than to mice at the tissue-transcriptome level.
ZOOLOGICAL RESEARCH
(2021)
Article
Biochemical Research Methods
Suchismita Behera, R. Rajendra Reddy, Khushman Taunk, Srikanth Rapole, Rajesh Raghunath Pharande, Amol Ratnakar Suryawanshi
Summary: This study used an advanced quantitative proteomics approach to identify differentially abundant proteins in dog brain tissues infected with furious rabies virus. The results showed that proteins associated with calcium signaling and transport pathway, efficient neuronal functions, and metabolic pathway were most altered during the infection. This study provides insight into the molecular pathogenesis of furious rabies virus infection.
JOURNAL OF PROTEOMICS
(2022)
Article
Biochemistry & Molecular Biology
Nan Wang, Shuang Bai, Feng Bei, Ning Zhao, Sisi Jia, Tao Jin, Jinxin Wang, Hengzhi Wang, Weitang Liu
Summary: This study reports on a population of Myosoton aquaticum L. that exhibits resistance to herbicides in the absence of known acetolactate synthase (ALS) resistance mutations, highlighting the role of non-target-site resistance mechanisms.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Biology
Richard J. Harris, Bryan G. Fry
Summary: The evolution of venom resistance through coevolutionary chemical arms races has been documented multiple times in the animal kingdom. Previous studies focused on N-glycosylation motifs and amino acid mutations in resistance to snake venom neurotoxins, but a new study has discovered a novel form of resistance through charge reversal mutations.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Virology
Madoka Horiya, Guillermo Posadas-Herrera, Mutsuyo Takayama-Ito, Yukie Yamaguchi, Itoe Iizuka-Shiota, Hirofumi Kato, Aikou Okamoto, Masayuki Saijo, Chang-Kweng Lim
Summary: Rabies virus is widely distributed and vaccination is an important preventive measure. This study conducted a genomic analysis of a chicken embryo cell culture vaccine strain and confirmed its genetic characteristics. The evaluated efficacy of the vaccine suggests it is suitable for preventing the current rabies virus.
Article
Immunology
Yue Zhang, Mengwei Zhang, Xilan Liao, Yunsong Yu, Qing Liu, Yongwen Luo, Jun Luo, Xiaofeng Guo
Summary: Rabies is an important zoonotic disease caused by the rabies virus (RABV). Researchers have found that inserting the interleukin-25 (IL-25) gene into the genome of RABV can enhance the immune responses induced by the rabies vaccine, leading to higher levels of virus neutralizing antibodies (VNA). Mice immunized with the recombinant RABV showed a higher survival rate and milder clinical signs after challenge with CVS-11, suggesting that IL-25 can be used as a viral vaccine adjuvant.
Article
Multidisciplinary Sciences
Lei Jin, Makoto Matsuyama, Heather A. Sullivan, Mulangma Zhu, Thomas K. Lavin, YuanYuan Hou, Nicholas E. Lea, Maxwell T. Pruner, Maria Lucia Dam Ferdinez, Ian R. Wickersham
Summary: Monosynaptic tracing using rabies virus is a valuable technique for neuroscience, but a 2017 article reported paradoxical results due to unintended mutations in the virus. The modified version with intended modifications did not efficiently spread without the expression of an exogenous protease. However, under certain conditions, the modified version was able to spread but resulted in the deaths of most source cells. Further optimization and validation are needed for this new approach to become robust.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Boyue Zhang, Ting Cai, Hongling He, Xuezhe Huang, Guie Chen, Yanqin Lai, Yongwen Luo, Shile Huang, Jun Luo, Xiaofeng Guo
Summary: Rabies is a highly fatal zoonotic disease with no effective treatment available. Recent studies have shown that the tripartite-motif protein (TRIM) family plays a role in regulating viral replication. Specifically, tripartite-motif protein 21 (TRIM21) has been found to be upregulated in the brain tissue of mice infected with rabies virus and its knockdown inhibits viral replication. Knockdown of interferon-alpha and interferon-beta further modulates the inhibition of viral replication caused by TRIM21 knockdown. TRIM21 regulates RABV replication via the IRF7-IFN axis, highlighting its potential as a target for rabies treatment or management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xing Liu, Fang Li, Jiwen Zhang, Lulu Wang, Jinliang Wang, Zhiyuan Wen, Zilong Wang, Lei Shuai, Xijun Wang, Jinying Ge, Dongming Zhao, Zhigao Bu
Summary: The study demonstrates that ATP6V1A interacts with RABV M protein to promote virus replication and is involved in viral uncoating process through specific residue interactions. Upregulation of ATP6V1A enhances RABV growth in cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Microbiology
Erdal Erol, Mariela Scortti, Jordan Fortner, Mukesh Patel, Jose A. Vazquez-Boland
Summary: Clonal multidrug resistance in Rhodococcus equi has complicated the therapeutic management of this pathogen, with the emergence of the MDR 2287 clone linked to acquisition of the pRErm46 plasmid and rpoB(S531F) mutation. Susceptibility testing showed generally susceptibility of R. equi isolates, including MDR ones, to a panel of antimicrobials according to specific criteria, with molecular analyses highlighting the link between pRErm46 and increased MICs for certain antibiotics and the emergence of novel MDR strains with different rpoB mutations.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Matteo Gentili, Joanna Kowal, Mercedes Tkach, Takeshi Satoh, Xavier Lahaye, Cecile Conrad, Marilyn Boyron, Berangere Lombard, Sylvere Durand, Guido Kroemer, Damarys Loew, Marc Dalod, Clotilde Thery, Nicolas Manel
Article
Virology
Xavier Lahaye, Nicolas Manel
CURRENT OPINION IN VIROLOGY
(2015)
Article
Cell Biology
Xavier Lahaye, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, Aymeric Silvin, Cecile Conrad, Abdelhakim Ahmed-Belkacem, Elisa C. Rodriguez, Jean-Francois Guichou, Nathalie Bosquet, Matthieu Piel, Roger Le Grand, Megan C. King, Jean-Michel Pawlotsky, Nicolas Manel
Review
Biochemistry & Molecular Biology
Anvita Bhargava, Xavier Lahaye, Nicolas Manel
CYTOKINE & GROWTH FACTOR REVIEWS
(2018)
Article
Biochemistry & Molecular Biology
Xavier Lahaye, Matteo Gentili, Aymeric Silvin, Cecile Conrad, Lea Picard, Mabel Jouve, Elina Zueva, Mathieu Maurin, Francesca Nadalin, Gavin J. Knott, Baoyu Zhao, Fenglei Du, Marlene Rio, Jeanne Amiel, Archa H. Fox, Pingwei Li, Lucie Etienne, Charles S. Bond, Laurence Colleaux, Nicolas Manel
Article
Immunology
Xavier Lahaye, Takeshi Satoh, Matteo Gentili, Silvia Cerboni, Cecile Conrad, Ilse Hurbain, Ahmed El Marjou, Christine Lacabaratz, Jean-Daniel Lelievre, Nicolas Manel
Article
Cell Biology
Gregory W. Moseley, Xavier Lahaye, Daniela M. Roth, Sibil Oksayan, Richard P. Filmer, Caitlin L. Rowe, Danielle Blondel, David A. Jans
JOURNAL OF CELL SCIENCE
(2009)
Article
Virology
Xavier Lahaye, Aurore Vidy, Baptiste Fouquet, Danielle Blondel
JOURNAL OF VIROLOGY
(2012)
Article
Cell Biology
Matteo Gentili, Xavier Lahaye, Francesca Nadalin, Guilherme F. P. Nader, Emilia Puig Lombardi, Solene Herve, Nilushi S. De Silva, Derek C. Rookhuizen, Elina Zueva, Christel Goudot, Mathieu Maurin, Aurore Bochnakian, Sebastian Amigorena, Matthieu Piel, Daniele Fachinetti, Arturo Londono-Vallejo, Nicolas Manel
Article
Cell Biology
Jarrod S. Johnson, Nicholas De Veaux, Alexander W. Rives, Xavier Lahaye, Sasha Y. Lucas, Brieuc P. Perot, Marine Luka, Victor Garcia-Paredes, Lynn M. Amon, Aaron Watters, Ghaith Abdessalem, Alan Aderem, Nicolas Manel, Dan R. Littman, Richard Bonneau, Mickael M. Menager
Article
Cell Biology
Federico Cocozza, Nathalie Nevo, Ester Piovesana, Xavier Lahaye, Julian Buchrieser, Olivier Schwartz, Nicolas Manel, Mercedes Tkach, Clotilde Thery, Lorena Martin-Jaular
JOURNAL OF EXTRACELLULAR VESICLES
(2020)
Article
Biochemistry & Molecular Biology
Marius Doring, Kevin De Azevedo, Guillermo Blanco-Rodriguez, Francesca Nadalin, Takeshi Satoh, Matteo Gentili, Xavier Lahaye, Nilushi S. De Silva, Cecile Conrad, Mabel Jouve, Mireille Centlivre, Yves Levy, Nicolas Manel
Summary: The study identified that infection of human DCs by MVA results in early viral gene expression and different responses in distinct clusters of DCs, including production of inflammatory cytokines, upregulation of costimulatory molecules, and apoptosis.
Article
Immunology
Aymeric Silvin, Chun I. Yu, Xavier Lahaye, Francesco Imperatore, Jean-Baptiste Brault, Sylvain Cardinaud, Christian Becker, Wing-Hong Kwan, Cecile Conrad, Mathieu Maurin, Christel Goudot, Santy Marques-Ladeira, Yuanyuan Wang, Virginia Pascual, Esperanza Anguiano, Randy A. Albrecht, Matteo Iannacone, Adolfo Garcia-Sastre, Bruno Goud, Marc Dalod, Arnaud Moris, Miriam Merad, A. Karolina Palucka, Nicolas Manel
SCIENCE IMMUNOLOGY
(2017)
Article
Cell Biology
Anvita Bhargava, Alice Williart, Mathieu Maurin, Patricia M. Davidson, Mabel Jouve, Matthieu Piel, Xavier Lahaye, Nicolas Manel
Summary: SUN1 and SUN2 have distinct antiviral activities, preferentially inhibiting HIV-1 and HIV-2 respectively, with SUN1 neutralizing the effects of DNA damage inducers. The study shows that chromatin dynamics and the DNA damage response play a significant role in controlling HIV infection by structural components of the nuclear envelope.