Article
Immunology
Juan F. Hernandez-Franco, Ganesh Yadagiri, Veerupaxagouda Patil, Dina Bugybayeva, Sara Dolatyabi, Ekachai Dumkliang, Mithilesh Singh, Raksha Suresh, Fatema Akter, Jennifer Schrock, Gourapura J. Renukaradhya, Harm Hogenesch
Summary: This study evaluated the effectiveness of commercially available cross-protective swIAV vaccines and monovalent whole inactivated H1N2 swine influenza vaccine when administered through different routes. The results showed that intradermal vaccination generated a stronger cross-reactive antibody response and higher avidity, and induced the production of both IgG and IgA virus-specific antibody-secreting cells.
Article
Materials Science, Biomaterials
Li Zhang, Xueliang Xiu, Zhipeng Li, Rui Su, Xuemei Li, Shichao Ma, Fengsen Ma
Summary: Porous microneedles (pMNs) are a novel transdermal drug delivery modality that can carry drugs and vaccines and exert a synergistic effect through the release of drugs and adjuvants in the skin. In this study, biocompatible pMNs with good mechanical properties and high porosity were successfully prepared. The coated pMNs induced an efficient immune response in rats. This research suggests that pMNs have a promising prospect for future applications in preventing global epidemics like influenza.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Immunology
Dana M. Gates, Steven A. Cohen, Kelly Orr, Aisling R. Caffrey
Summary: The study evaluated trends in pharmacist-administered pediatric influenza vaccination rates in the United States, finding low utilization rates with regional variations. Improving accessibility to pediatric vaccination may increase overall vaccination rates.
Article
Virology
Ashley Moreland, Christina Gillezeau, Naomi Alpert, Emanuela Taioli
Summary: Vaccination campaigns targeting influenza are effective in reaching those most vulnerable to serious COVID-19, and if implemented, may help reach more vulnerable individuals who have not yet been vaccinated against COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Engineering, Biomedical
Haochen Wang, Junhua Xu, Lin Xiang
Summary: Efforts are being made to explore economical and efficient vaccination methods to combat frequent global epidemics. Nucleic acid vaccines have attracted much attention due to their design flexibility and wide application, but their clinical translation is limited by the lack of an efficient delivery system. Microneedles offer a painless, cost-effective, and efficient drug delivery strategy, breaking through the skin barrier to deliver vaccines to immune cell-rich areas. Preclinical and clinical studies have shown the feasibility of microneedle-mediated vaccination and its potential for nucleic acid vaccine delivery. This review summarizes the current research status and improvements in microneedle vaccines, as well as the challenges for future clinical translation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Immunology
Noopur Bhatnagar, Ki-Hye Kim, Jeeva Subbiah, Sakinah Muhammad-Worsham, Bo Ryoung Park, Rong Liu, Phillip Grovenstein, Bao-Zhong Wang, Sang-Moo Kang
Summary: The study suggests that heterologous prime-boost influenza vaccination strategy is more effective in inducing broader protective immunity compared to repeated vaccination with the same antigen, by increasing strain-specific hemagglutination inhibition titers and high levels of IgG antibodies.
Article
Pediatrics
Stacey L. Rowe, Karin Leder, Kirsten P. Perrett, Nicole Romero, Terry M. Nolan, Nicola Stephens, Benjamin C. Cowie, Allen C. Cheng
Summary: This study demonstrates the direct effectiveness of maternal influenza and pertussis vaccination in preventing these diseases in infants aged <2 months. The findings emphasize the significance of maternal vaccination in preventing these diseases in infants.
Article
Biotechnology & Applied Microbiology
Ilan Green, Shai Ashkenazi, Eugene Merzon, Shlomo Vinker, Avivit Golan-Cohen
Summary: Studies have shown similarities between influenza and coronaviruses in terms of structure, binding receptors, and immune responses. Influenza vaccine can induce cross-immunity. The research suggests that influenza vaccination could reduce the risk of SARS-CoV-2 infection, making it highly recommended before the influenza season to lessen the burden of influenza outbreaks and their association with reduced rates of COVID-19.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Education & Educational Research
Carrie Ann Hall, Christy Skelly, Nancy Marc, Judy Risko
Summary: The study found that college students who received intradermal influenza vaccination on a college campus were more likely to prefer this method in the future and reported experiencing less pain. Moreover, individuals who reported greater pain with intramuscular injection in the past were significantly more likely to opt for intradermal injection in the future.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2021)
Article
Multidisciplinary Sciences
Cassie Caudill, Jillian L. Perry, Kimon Iliadis, Addis T. Tessema, Brian J. Lee, Beverly S. Mecham, Shaomin Tian, Joseph M. DeSimone
Summary: Faceted microneedles produced with CLIP 3D printing technology show improved surface coating of vaccine components, enhanced cargo retention in skin, immune cell activation, and humoral immune response, as well as eliciting T cell responses in animal models. This platform offers a promising approach for noninvasive, self-applicable vaccination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Xin Fan, Ning Li, Meiyi Xu, Decheng Yang, Beinan Wang
Summary: Intrapulmonary immunization with a subunit vaccine shows significant effects in combating Staphylococcus aureus lung infection, reducing bacterial colonization, alleviating inflammation, boosting antimicrobial abilities, and providing long-lasting protection.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biology
Jie Mao, Gi-Deok Eom, Keon-Woong Yoon, Hae-Ji Kang, Ki-Back Chu, Fu-Shi Quan
Summary: Both sublingual and oral immunization can induce protective immunity against influenza virus infection, with sublingual immunization being more effective.
Article
Immunology
Andrew Chak-Yiu Lee, Anna Jinxia Zhang, Can Li, Yanxia Chen, Feifei Liu, Yan Zhao, Hin Chu, Carol Ho-Yan Fong, Pui Wang, Siu-Ying Lau, Kelvin Kai-Wang To, Honglin Chen, Kwok-Yung Yuen
Summary: Intradermal vaccination with DelNS1-LAIV provides potent and long-lasting protection against lethal virus challenge in mice, reducing viral load, epithelial cell death, and inflammatory responses. Activation of antigen-presenting cells and strong immunogenicity suggest that antibody responses play a key role in the protection induced by intradermal DelNS1-LAIV, offering an alternative route for LAIV administration.
Article
Immunology
Swathi Gopalaiah, Kshama M. Appaiah, Shrikrishna Isloor, Dilip Lakshman, Ramesh P. Thimmaiah, Suguna Rao, Mahadevappa Gouri, Naveen Kumar, Kavitha Govindaiah, Avinash Bhat, Simmi Tiwari
Summary: Administering rabies pre-exposure prophylactic vaccine through intramuscular (IM) and intradermal (ID) routes proved to be effective and safe in protecting cattle against rabies. The ID route was more economical due to its dose-sparing effect. Both routes can be considered for pre-exposure prophylaxis.
Article
Immunology
Cornelis A. De Pijper, Annefleur C. Langedijk, Sanne Terryn, Steven Van Gucht, Martin P. Grobusch, Abraham Goorhuis, Cornelis Stijnis
Summary: Long-lasting immunological rabies memory can be quickly reactivated within 7 days after a single intramuscular booster immunization, even when administered 10-24 years after pre-exposure prophylaxis.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
J. Jeremy Chae, Jae Hwan Jung, Wei Zhu, Brandon G. Gerberich, Mohammad Reza Bahrani Fard, Hans E. Grossniklaus, C. Ross Ethier, Mark R. Prausnitz
Summary: The study developed a drug-free, nonsurgical method to lower intraocular pressure in glaucoma patients, using hyaluronic acid hydrogel injections to stabilize IOP reduction for 4 months. Safety assessment showed good tolerance of the treatment, which can effectively treat glaucoma.
Editorial Material
Engineering, Biomedical
Youngeun Kim, Mark R. Prausnitz
Summary: This minimally invasive microneedle patch detects specific protein biomarkers in dermal interstitial fluid with high sensitivity through a needle-integrated immunoassay coupled with an ultrabright fluorescent label.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Instruments & Instrumentation
Erkan Azizoglu, Ozgen Ozer, Mark R. Prausnitz
Summary: The study developed dissolving microneedle patches for transdermal delivery of montelukast sodium, showing drug localization and selective loading can be achieved through solvent washing method, with demonstrated stability in storage and delivery efficiency.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Jie Tang, Richard Schutzman, Carlos A. Rodriguez, Joerg Lahann, Nair Rodriguez-Hornedo, Mark R. Prausnitz, Steven P. Schwendeman
Summary: This study aimed to develop an injectable poly(D,L-lactide) (PLA) microparticle for sustained release of contraceptive hormone, etonogestrel (ENG). The ENG-cs-MPs prepared by the coaxial electrospray method showed high drug loading, high encapsulation efficiency, and long-term stable release, suggesting their potential as a long-acting injectable contraceptive with improved pharmacokinetic profile.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Simple Kumar, Andrew Li, Naresh N. Thadhani, Mark R. Prausnitz
Summary: The study showed that optimizing intracellular macromolecule delivery by nanoparticle-mediated photoporation can be achieved by prolonged exposure at low laser fluence, potentially due to longer time for molecules to diffuse into cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Review
Nanoscience & Nanotechnology
Wei Li, Jie Tang, Dennis Lee, Thomas R. Tice, Steven P. Schwendeman, Mark R. Prausnitz
Summary: Long-acting drug delivery formulations enable sustained and prolonged drug release, improving patient compliance. This review discusses FDA-approved long-acting drug delivery formulations, including different slow-release mechanisms and materials, and provides a comprehensive summary of their clinical applications and product information.
NATURE REVIEWS MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Rohan Murty, Abishek Sankaranarayanan, Isabella I. Bowland, Juan Mena-Lapaix, Mark R. Prausnitz
Summary: This study successfully localized antigen delivery to the epidermis using angled insertion of microneedles. Angled insertion significantly reduced microneedle insertion depth and increased epidermal localization of antigen delivery.
Article
Endocrinology & Metabolism
Kevin T. Nguyen, Nicole Y. Xu, Jennifer Y. Zhang, Trisha Shang, Ananda Basu, Richard M. Bergenstal, Kristin Castorino, Kong Y. Chen, David Kerr, Suneil K. Koliwad, Lori M. Laffel, Nestoras Mathioudakis, L. Kurt Midyett, Joshua D. Miller, James H. Nichols, Francisco J. Pasquel, Priya Prahalad, Mark R. Prausnitz, Jane Jeffrie Seley, Jennifer L. Sherr, Elias K. Spanakis, Guillermo E. Umpierrez, Amisha Wallia, David C. Klonoff
Summary: This article is the outcome of the Continuous Ketone Monitoring Consensus Panel, which consisted of 20 US-based experts. The panel reviewed medical literature on various topics related to continuous ketone monitoring and developed 30 conclusions unanimously. The report aims to support the development and application of this technology for the benefit of people with diabetes.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2022)
Article
Instruments & Instrumentation
Hagar Labouta, Robert Langer, Pieter R. Cullis, Olivia M. Merkel, Mark R. Prausnitz, Yasmine Gomaa, Sara S. Nogueira, Tushar Kumeria
Summary: The successful development of mRNA vaccines highlights the crucial role of drug delivery technologies in protecting billions of people from COVID-19. These vaccines, built upon years of scientific research in mRNA drug delivery, vaccines, and other biologicals, have proven to be safe and effective in preventing the disease.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Ophthalmology
Brandon G. Gerberich, Bailey G. Hannon, Dillon M. Brown, A. Thomas Read, Matthew D. Ritch, Elisa Schrader Echeverri, Lauren Nichols, Cahil Potnis, Sreesh Sridhar, Maya G. Toothman, Stephen A. Schwaner, Erin J. Winger, Hannah Huang, Gabby S. Gershon, Andrew J. Feola, Machelle T. Pardue, Mark R. Prausnitz, C. Ross Ethier
Summary: This study assessed the neuroprotective effects of scleral stiffening treatments in an experimental model of glaucoma. The results showed that neither global nor local scleral stiffening provided demonstrable neuroprotection in hypertensive eyes.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Brandon G. Gerberich, Amy J. Wood-Yang, Afsane Radmand, Lauren M. Nichols, Amir Hejri, Elisa Schrader Echeverri, Hannah G. Gersch, Mark R. Prausnitz
Summary: A computational model was developed to predict the crosslinking efficiency of visible/near infrared photosensitizers in the sclera for the treatment of myopia and glaucoma. The study validated photocrosslinking against riboflavin corneal crosslinking experimental studies and simulated the treatment using methylene blue administered by retrobulbar injection and irradiated with a transpupillary light beam. Optimal ranges for treatment parameters were determined and the sensitivity of crosslinking to various parameters was quantified, with oxygen concentration in the injection solution, scleral thickness, and injection volume being the most sensitive parameters.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Wei Li, Jonathan Yuxuan Chen, Richard N. Terry, Jie Tang, Andrey Romanyuk, Steven P. Schwendeman, Mark R. Prausnitz
Summary: There is a great need for a simple and long-acting contraception method. This study developed a core-shell microneedle patch that achieved zero-order release of a contraceptive hormone for 6 months, compared to a monolithic microneedle patch with a shorter release time. The core-shell design effectively controlled the burst release of the hormone.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Song Li, Youngeun Kim, Jeong Woo Lee, Mark R. Prausnitz
Summary: Single-use microneedle patches have been developed for painless and bloodless tattooing, which can provide medical information, respond to physiological changes, and encode personal health information. These patches offer increased safety and access to medical tattoos for improved cosmetic outcomes.
Article
Engineering, Biomedical
Andrey Romanyuk, Ruixue Wang, Alexander Marin, Benjamin M. M. Janus, Eric I. I. Felner, Dengning Xia, Yenny Goez-Gazi, Kendra J. J. Alfson, Abdul S. S. Yunus, Eric A. A. Toth, Gilad Ofek, Ricardo Carrion Jr, Mark R. R. Prausnitz, Thomas R. R. Fuerst, Alexander K. K. Andrianov
Summary: This study describes a novel MN technology that combines EBOV GP antigen with a polyphosphazene-based immunoadjuvant and vaccine delivery system. The prepared dissolvable EBOV GP MN patch vaccine showed superior antigenicity compared to a non-polyphosphazene polymer-based analog. Mice vaccinated with the polyphosphazene-based MN patches exhibited strong antibody responses against EBOV GP and complete protection against lethal challenge.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Youngeun Kim, Jae Hwan Jung, Andrew R. Tadros, Mark R. Prausnitz
Summary: Topical application of STAR particles with microneedle protrusions can create micropores on the skin, significantly increasing skin permeability even to water-soluble compounds and macromolecules. This study demonstrates the tolerability, acceptability, and reproducibility of STAR particles on human subjects at various pressures and repeated applications. The results show that one-time application of STAR particles at pressures between 40 and 80 kPa leads to skin microporation and erythema, with increased pressure directly correlating to these effects, and most subjects reported comfort with STAR particles. Repeated application for 10 consecutive days at 80 kPa showed similar skin microporation, erythema, and comfort, indicating the safety and reliability of STAR particles for enhancing cutaneous drug delivery.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)