Review
Microbiology
Takashi Hatano, Daisuke Sano, Hideaki Takahashi, Nobuhiko Oridate
Summary: The incidence of oropharyngeal cancer is increasing due to its association with HPV, which can evade the immune system and integrate into the host genome, contributing to oncogenesis.
Article
Immunology
Hella Pasmans, Magdalena A. Berkowska, Annieck M. Diks, Bas de Mooij, Rick J. Groenland, Lia de Rond, M. Alina Nicolaie, Sjoerd H. van der Burg, Jacques J. M. van Dongen, Fiona R. M. van der Klis, Anne-Marie Buisman
Summary: A study comparing immune responses in women vaccinated with bivalent and nonavalent HPV vaccines found consistent expansion of plasma cells and monocytes, but varied responses in other immune cells. Antibody levels and memory B and T-cell responses also differed between the two vaccine groups.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Ashley N. Della Fera, Alix Warburton, Tami L. Coursey, Simran Khurana, Alison A. McBride
Summary: Persistent infection with oncogenic human papillomavirus (HPV) types contributes to approximately 5% of human cancers. The HPV infectious cycle and viral proteins manipulate cellular proliferation and differentiation, increasing the risk of carcinogenesis in infected cells.
Article
Biochemistry & Molecular Biology
Jian Xie, Daniel DiMaio
Summary: Historically, genetic analysis of mammalian cells involved isolating randomly arising mutant cell lines to identify the mutant gene responsible for altered properties. Recent advancements in somatic cell genetics have introduced functional genomics screens which systematically perturb the expression of every protein-coding gene to determine the resulting phenotype. A novel functional genomics screening strategy has been outlined where libraries of artificial transmembrane proteins, called traptamers, are expressed to select rare cells with desired phenotypes that can help dissect complex biological processes. By using this new strategy, insights into the process of how human papillomaviruses enter cells have been gained.
Review
Pharmacology & Pharmacy
Ramar Vanajothi, Natarajan Srikanth, Rajendran Vijayakumar, Manikandan Palanisamy, Sundaresan Bhavaniramya, Kumpati Premkumar
Summary: This article discusses how HPV virus evades the host immune system and leads to disease progression. The development of vaccines for HPV infection and associated diseases is crucial, but effective antiviral drugs are currently lacking.
CURRENT DRUG TARGETS
(2022)
Article
Virology
Caleb J. Studstill, Cary A. Moody
Summary: High-risk HPVs activate and exploit DNA damage response pathways to promote viral replication, which increases the susceptibility of the host cell to genomic instability and carcinogenesis.
ANNUAL REVIEW OF VIROLOGY
(2023)
Review
Oncology
Lourdes Gutierrez-Xicotencatl, Adolfo Pedroza-Saavedra, Lilia Chihu-Amparan, Azucena Salazar-Pina, Minerva Maldonado-Gama, Fernando Esquivel-Guadarrama
Summary: HPV is recognized as the main cause of cervical cancer, with low-risk and high-risk types. High-risk HPV types 16 and 18 are the most common worldwide. The oncogenic proteins E6 and E7 play a major role in cancer development, while E5 is involved in the early stages of transformation.
MOLECULAR CANCER RESEARCH
(2021)
Article
Obstetrics & Gynecology
Naoya Akiba, Takayuki Iriyama, Toshio Nakayama, Takahiro Seyama, Seisuke Sayama, Keiichi Kumasawa, Atsushi Komatsu, Shinichiro Yabe, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
Summary: The study investigates the spontaneous outcomes of vascularized retained products of conception (RPOC) after second-trimester abortion and predictive factors for severe postpartum hemorrhage (SPPH). Patients with type 3 RPOC and a maximum vascularized mass diameter >= 30 mm are at a higher risk of developing SPPH. Ultrasonographic assessment focusing on the depth of vascularity in combination with the measurement of size is essential in identifying women with RPOC at high risk for SPPH.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Midori Yoshikawa, Takayuki Iriyama, Kensuke Suzuki, Seisuke Sayama, Tetsushi Tsuruga, Keiichi Kumasawa, Takeshi Nagamatsu, Kengo Homma, Isao Naguro, Yutaka Osuga, Hidenori Ichijo, Tomoyuki Fujii
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Ayumi Taguchi, Konan Hara, Jun Tomio, Kei Kawana, Tomoki Tanaka, Satoshi Baba, Akira Kawata, Satoko Eguchi, Tetsushi Tsuruga, Mayuyo Mori, Katsuyuki Adachi, Takeshi Nagamatsu, Katsutoshi Oda, Toshiharu Yasugi, Yutaka Osuga, Tomoyuki Fujii
Article
Oncology
Yoshiaki Maru, Akira Kawata, Ayumi Taguchi, Yoshiyuki Ishii, Satoshi Baba, Mayuyo Mori, Takeshi Nagamatsu, Katsutoshi Oda, Iwao Kukimoto, Yutaka Osuga, Tomoyuki Fujii, Yoshitaka Hippo
Article
Obstetrics & Gynecology
Keiichi Kumasawa, Takayuki Iriyama, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2020)
Article
Rheumatology
Kenji Tanimura, Shigeru Saito, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Atsushi Fukui, Masashi Deguchi, Yuki Sasagawa, Noriko Arase, Hisashi Arase, Hideto Yamada
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Obstetrics & Gynecology
Hiroaki Itoh, Keisuke Ishii, Naoya Shigeta, Atsuo Itakura, Hiromi Hamada, Takeshi Nagamatsu, Tomohiko Ishida, Yasuaki Bungyoku, Ali Falahati, Miori Tomisaka, Mikiya Kitamura
Summary: The study evaluated the efficacy and safety of dinoprostone vaginal insert (PROPESS) in pregnant post-term Japanese women requiring cervical ripening. Results showed that PROPESS administration for up to 12 hours significantly increased successful cervical ripening rate, shortened time to vaginal delivery, and reduced the need for uterotonic drugs such as oxytocin.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Obstetrics & Gynecology
Tamae Nabeshima, Tatsuya Fujii, Takeshi Nagamatsu, Ayako Hashimoto, Takahiro Seyama, Kaori Kubota, Seisuke Sayama, Toshio Nakayama, Keiichi Kumasawa, Takayuki Iriyama, Yutaka Osuga, Tomoyuki Fujii
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2020)
Article
Obstetrics & Gynecology
Ryosuke Shindo, Shigeru Aoki, Toshihiro Misumi, Sayuri Nakanishi, Takeshi Umazume, Takeshi Nagamatsu, Hisashi Masuyama, Atsuo Itakura, Tomoaki Ikeda
Summary: In Japan, the criteria for the latent and active phases of the first stage of labor have not been determined. A study was conducted to construct a spontaneous labor curve, showing that labor progress is slow until 5 cm cervical dilation, accelerates between 5 and 6 cm, and steadily progresses after 6 cm dilation. The active phase of labor is proposed to start at 5 cm dilation of the cervix, divided into an acceleration phase (5-6 cm dilation) and a maximal phase (>6 cm dilation).
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Obstetrics & Gynecology
Megumi Nakanishi, Takayuki Iriyama, Seisuke Sayama, Shouhei Hanaoka, Masatake Toshimitsu, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Yutaka Osuga
Summary: Uterine degeneration occurs during pregnancy in cases of adenomyosis, causing worsened symptoms, but this degeneration is transient and disappears completely after childbirth.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Review
Hematology
Hiroko Oda, Takeshi Nagamatsu, Yutaka Osuga
Summary: Thrombomodulin (TM) has multiple organ protective roles during pregnancy, aside from its anticoagulation function. Placental TM deficiency is associated with pregnancy complications such as miscarriage, fetal growth restriction, and preeclampsia. Recombinant TM shows promise as a therapeutic target for these conditions.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Obstetrics & Gynecology
Minori Kasuya, Naoya Akiba, Takayuki Iriyama, Seisuke Sayama, Kaori Kubota, Masatake Toshimitsu, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Tomoyuki Fujii, Yutaka Osuga
Summary: This study aimed to compare the impact of fetal growth restriction (FGR) and maternal organ dysfunction on the severity of maternal preeclamptic features. The results showed that PE cases preceded by FGR had earlier diagnosis and delivery, but there were no significant differences in maternal morbidities compared to cases without FGR. For early-onset PE, the results were comparable between two groups.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Mari Ichinose, Takayuki Iriyama, Seisuke Sayama, Masatake Toshimitsu, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Shouhei Hanaoka, Yutaka Osuga
Summary: This is the first report on the imaging findings of early postpartum degeneration of adenomyosis, based on a case of a patient who underwent pregnancy. The magnetic resonance imaging showed cyst-like degenerations with hemorrhagic changes.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Risa Miyatake, Tatsuya Fujii, Keiichi Kumasawa, Mari Ichinose, Masatake Toshimitsu, Seisuke Sayama, Takahiro Seyama, Takayuki Iriyama, Takeshi Nagamatsu, Yutaka Osuga
Summary: Hyperreactio luteinalis (HL) is a rare condition characterized by bilateral ovarian enlargement during pregnancy. It is usually caused by increased production of human chorionic gonadotropin (hCG) associated with gestational trophoblastic diseases or multiple pregnancies. While the prognosis is generally good, obstetric complications such as preeclampsia (PE) and preterm births can occur. Monitoring the sFlt-1/PlGF ratio is found to be useful in managing HL cases associated with PE.
CASE REPORTS IN OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Yuko Takahashi, Takeshi Nagamatsu, Tatsuya Fujii, Ayako Hashimoto, Seisuke Sayama, Takahiro Seyama, Takayuki Iriyama, Keiichi Kumasawa, Yutaka Osuga, Tomoyuki Fujii
OXFORD MEDICAL CASE REPORTS
(2020)