期刊
JOURNAL OF VIROLOGY
卷 84, 期 20, 页码 10907-10912出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01357-10
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资金
- NIH [RO1 AI076114, RO1 AI049120]
- NCRR [P51 RR000167]
- Research Facilities Improvement Program [RR15459-01, RR020141-01]
The kinetics of CD8(+) T cell epitope presentation contribute to the antiviral efficacy of these cells yet remain poorly defined. Here, we demonstrate presentation of virion-derived Vpr peptide epitopes early after viral penetration and prior to presentation of Vif-derived epitopes, which required de novo Vif synthesis. Two Rev epitopes exhibited differential presentation kinetics, with one Rev epitope presented within 1 h of infection. We also demonstrate that cytolytic activity mirrors the recognition kinetics of infected cells. These studies show for the first time that Vpr- and Rev-specific CD8(+) T cells recognize and kill simian immunodeficiency virus (SIV)-infected CD4(+) T cells early after SIV infection.
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