Article
Microbiology
Makoto Ohashi, Mitchell Hayes, Kyle McChesney, Eric Johannsen
Summary: EBV infection can lead to specific types of lymphoma and some epithelial cancers. In vitro, EBV infection of resting B-lymphocytes drives them to proliferate as lymphoblastoid cell lines, serving as a model for studying EBV lymphomagenesis. This study reveals that interaction between EBNA3C and CtBP results in EBNA3C-mediated upregulation.
Article
Oncology
Samantha S. Soldan, Emma M. Anderson, Drew M. Frase, Yue Zhang, Lisa B. Caruso, Yin Wang, Julianna S. Deakyne, Benjamin E. Gewurz, Italo Tempera, Paul M. Lieberman, Troy E. Messick
Summary: The study demonstrated that the EBNA1 inhibitor VK-1727 selectively inhibited cell growth in EBV-positive gastric carcinoma and reduced tumor growth in animal models, but not in EBV-negative gastric carcinoma. Short-term treatment tended to activate viral genes, while long-term treatment resulted in significant decrease in viral gene expression.
Article
Multidisciplinary Sciences
Chong Wang, Xiang Liu, Jun Liang, Yohei Narita, Weiyue Ding, Difei Li, Luyao Zhang, Hongbo Wang, Merrin Man Long Leong, Isabella Hou, Catherine Gerdt, Chang Jiang, Qian Zhong, Zhonghui Tang, Carmy Forney, Leah Kottyan, Matthew T. Weirauch, Benjamin E. Gewurz, Mu-sheng Zeng, Sizun Jiang, Mingxiang Teng, Bo Zhao
Summary: EBV controls lymphocyte growth and transformation by reorganizing the host genome architecture to facilitate the expression of oncogenes.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Yiran Qu, Bingyang Zhang, Yingli Wang, Shuang Yin, Jordan L. Pederick, John B. Bruning, Yan Sun, Anton Middelberg, Jingxiu Bi
Summary: The study investigated the relationship between insertion sites in ferritin (N-terminus and C-terminus) and immune responses, finding that C-terminus insertion resulted in a stronger cell-mediated immune response than N-terminus insertion. This research provides new insights into the development of ferritin nanoparticle vaccines.
Article
Gastroenterology & Hepatology
Hui Song, Yan Zhang, Juanjuan Liu, Wen Liu, Bing Luo
Summary: The study revealed a new mechanism of EBV in regulating the expression of DNMT3a in EBV-associated gastric carcinoma. Targeting the EBNA1/E2F1/DNMT3a axis could be a potential therapeutic strategy for EBVaGC with high DNMT3a expression.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Microbiology
Jayaraju Dheekollu, Andreas Wiedmer, Samantha S. Soldan, Leonardo Josue Castro-Munoz, Christopher Chen, Hsin-Yao Tang, David W. Speicher, Paul M. Lieberman
Summary: EBV is associated with various malignancies and autoimmune disease. EBNA1 is essential for viral episome maintenance and DNA replication. PLOD1 interacts with EBNA1, regulates its protein stability, and plays a role in viral persistence and DNA replication.
Article
Biochemical Research Methods
Hansaim Lim, Chung-Jung Tsai, Ozlem Keskin, Ruth Nussinov, Attila Gursoy
Summary: HMI-PRED 2.0 is a publicly available web service that predicts host-microbe protein-protein interaction using interface mimicry. It aims to be user-friendly without requiring extensive computational experience.
Article
Clinical Neurology
Brit Ellen Rod, Stig Wergeland, Kjetil Bjornevik, Trygve Holmoy, Elling Ulvestad, Gro Njolstad, Kjell-Morten Myhr, Oivind Torkildsen
Summary: B cell depletion therapy leads to a decrease in EBNA1 IgG levels and an increase in VCA IgG levels in patients with multiple sclerosis (MS). This supports the hypothesis that the mechanism of action for B cell depletion therapy may be mediated by effects on EBV infection.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Microbiology
Katherine A. Willard, Ashley P. Barry, Cliff I. Oduor, John Michael Ong'echa, Jeffrey A. Bailey, Ann M. Moormann, Micah A. Luftig
Summary: In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. These findings provide insight into viral and host factors involved in this process and the potential contribution of promiscuous lytic activity to the formation of EBV-associated diseases.
Review
Virology
Boris Ryabchenko, Vojtech Sroller, Lenka Hornikova, Alexey Lovtsov, Jitka Forstova, Sandra Huerfano
Summary: This review provides detailed descriptions of the diverse and complex interactions between small and medium size DNA viruses and promyelocytic leukemia nuclear bodies (PM NBs). The interactions between PM NB components and viruses can influence viral genome expression and/or replication, as well as IFN-mediated or apoptotic cell responses to viral infection. The review also discusses the interactions between PM NBs and Hepatitis B virus, papillomaviruses, polyomaviruses, and avian anellovirus. Despite numerous studies on the functions of PM NBs in the context of viral infection, there are still gaps in our understanding of the fine interactions between viruses and the highly dynamic PM NBs, which require further investigation.
Article
Biology
Myriam Scherer, Clarissa Read, Gregor Neusser, Christine Kranz, Anna K. Kuderna, Regina Mueller, Florian Full, Sonja Woerz, Anna Reichel, Eva-Maria Schilling, Paul Walther, Thomas Stamminger
Summary: PML nuclear bodies undergo rearrangement to form giant cages upon viral infection, trapping viral genomes and capsids, and providing a multilayered defense strategy against viral infections.
Article
Multidisciplinary Sciences
Jiao Chen, Zuer Lu, Weibin Gong, Xue Xiao, Xiaoli Feng, Wei Li, Shan Shan, Dongyi Xu, Zheng Zhou
Summary: Inhibition of host DNA damage response (DDR) by viruses is a common mechanism to manipulate host cellular machinery and orchestrate viral life cycles. Here, the study reveals the structural basis of Epstein-Barr virus tegument protein BKRF4 binding to partially unfolded nucleosomes and elucidates an unconventional mechanism of host DDR signal attenuation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Mathias Montenarh, Friedrich A. Graesser, Claudia Goetz
Summary: Protein kinase CK2 is a versatile kinase that phosphorylates various cellular and viral proteins, playing important roles in cellular signaling, cell proliferation, apoptosis, angiogenesis, immune response, migration, and invasion. It is also involved in viral infection and the generation of cancer cells. Specifically, in Epstein-Barr virus infection, CK2 phosphorylates viral and cellular proteins, contributing to virus replication and cell transformation.
Article
Oncology
Louise Zanella, Maria Elena Reyes, Ismael Riquelme, Michel Abanto, Daniela Leon, Tamara Viscarra, Carmen Ili, Priscilla Brebi
Summary: EBV, a globally distributed pathogen, is associated with various human cancers originating from B-cells and non-B-cells. The virus is classified into EBV-1 and EBV-2, differing in their transformation abilities, with EBV-1 being more efficient in transforming B-cells into LCL and EBV-2 preferring T-cell lymphocyte infection. The EBNA3A oncoprotein plays an essential role in B-cell transformation and has six nuclear localization signals (NLSs) that regulate nucleocytoplasmic protein trafficking, with variations in genetic patterns associated with EBV types.
Article
Virology
Cui Lin, Jingyu Hu, Yadong Dai, Huandong Zhang, Kang Xu, Weiren Dong, Yan Yan, Xiran Peng, Jiyong Zhou, Jinyan Gu
Summary: Circovirus is the smallest virus to cause immune suppression in pigs. The nuclear entry and stability of the capsid protein (Cap) of porcine circovirus type 2 (PCV2) are crucial for its infection and replication. IPO5 acts as a host factor that maintains self-stability of PCV2 virions and promotes their nuclear import. By directly binding to Cap, IPO5 blocks proteasome degradation and facilitates PCV2 replication.
JOURNAL OF VIROLOGY
(2022)