Article
Cell Biology
Robert J. J. Jansens, Ruth Verhamme, Aashiq H. Mirza, Anthony Olarerin-George, Cliff Van Waesberghe, Samie R. Jaffrey, Herman W. Favoreel
Summary: Chemical modifications of mRNA, such as N6-methyladenosine (m6A), play a role in post-transcriptional gene regulation. This study found that alphaherpesvirus kinases can trigger phosphorylation of components of the m6A methyltransferase complex, leading to its inhibition and a decrease in m6A levels in virus-infected cells. The viral US3 protein is responsible for this phosphorylation and inhibition, and while inactivation of the m6A methyltransferase complex is not necessary for virus replication, the m6A methylation motif is underrepresented in alphaherpesvirus genomes.
Review
Pharmacology & Pharmacy
Hae Jin Kee, Inkyeom Kim, Myung Ho Jeong
Summary: This article provides an overview of the pathogenesis of hypertension, current anti-hypertensive drugs, and the need for novel drugs. It focuses on the role and regulatory mechanisms of HDACs in hypertension and discusses the progress in developing HDAC inhibitors as potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Nikolaos Garmpis, Christos Damaskos, Dimitrios Dimitroulis, Gregory Kouraklis, Anna Garmpi, Panagiotis Sarantis, Evangelos Koustas, Alexandros Patsouras, Iason Psilopatis, Efstathios A. Antoniou, Michail Karamouzis, Konstantinos Kontzoglou, Afroditi Nonni
Summary: This study found a relationship between HDAC-2 expression and clinical features and survival of breast cancer. Higher expression of HDAC-2 was correlated with the aggressiveness and poor prognosis of breast cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Veterinary Sciences
Tong Zhou, Mingshu Wang, Anchun Cheng, Qiao Yang, Bin Tian, Ying Wu, Renyong Jia, Shun Chen, Mafeng Liu, Xin-Xin Zhao, Xuming Ou, Sai Mao, Di Sun, Shaqiu Zhang, Dekang Zhu, Juan Huang, Qun Gao, Yanling Yu, Ling Zhang
Summary: This article mainly describes the viral protein kinases and their mechanisms of regulating viral protein function through phosphorylation. The study of post-translational modification of viral proteins is of great significance for understanding viral infection mechanisms and developing antiviral treatment.
VETERINARY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wenkai Zhou, Jiaming Wang, Xin Wang, Bingjing Wang, Zhehui Zhao, Jie Fu, Yan Wang, Xuan Zhang, Ping Zhu, Minghong Jiang, Xuetao Cao
Summary: HDAC10 plays an important role in immune response by inhibiting the production of type I interferon through regulating the phosphorylation of IRF3. Deficiency in HDAC10 leads to enhanced antiviral response by promoting the expression of type I interferons and interferon-stimulated genes.
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Valentina Dzreyan, Svetlana Sharifulina
Summary: Cerebral ischemia is the second leading cause of death worldwide, requiring multimodal stroke therapy. Histone deacetylase inhibitors have shown to be effective in protecting the brain from ischemic damage by inducing neurogenesis and angiogenesis in damaged brain areas, promoting functional recovery after stroke.
Review
Oncology
Fengyi Guo, Hongjing Wang
Summary: This review summarizes the classification and mechanisms of action of histone deacetylase and the clinical application of their inhibitors in ovarian cancer. Histone deacetylase inhibitors show promising potential as anti-cancer drugs, and combination therapy with other anticancer drugs for synergistic effects can improve efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Yuqi Jiang, Jie Xu, Kairui Yue, Chao Huang, Mengting Qin, Dongyu Chi, Qixin Yu, Yue Zhu, Xiaohan Hou, Tongqiang Xu, Min Li, C. James Chou, Xiaoyang Li
Summary: The study focused on modifying HDAC inhibitors to deactivate the Michael reaction in order to improve their potency. Compound 11h showed significant improvements in both HDAC inhibitory activity and cell-based antitumor assay, demonstrating potential for clinical application and efficacy against AML.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Taegwan Yun, Hyo Rim Ko, Dong-Kyu Jo, Kye Won Park, Sung-Woo Cho, Jihoe Kim, Jee-Yin Ahn
Summary: This study identified Id2 as a novel MT-binding partner that enhances alpha K40 acetylation, promoting MT polymerization in neurons. The research suggests that Id2 is critical for maintaining MT stability during neural development and has the potential to counteract pathogenic Sirt2 activity in Alzheimer's disease (AD).
CELL DEATH DISCOVERY
(2021)
Article
Chemistry, Medicinal
Kairui Yue, Simin Sun, Geng Jia, Mengting Qin, Xiaohan Hou, C. James Chou, Chao Huang, Xiaoyang Li
Summary: This study reports the development of a highly selective HDAC6 inhibitor with hydrazide as the zinc-binding group (ZBG), which exhibits superior pharmacokinetic properties compared to current hydroxamic acid inhibitors. Structure-activity relationship analysis reveals that the presence of an ethyl group substituent in the hydrazide-based ZBG and a cap group with increased rigidity and volume enhance the HDAC6 selectivity of the designed compounds. The representative inhibitor 35m demonstrates potent HDAC6 inhibitory activity and improved pharmacokinetic properties compared to hydroxamic acid-based HDAC6 inhibitors Tubastatin A and ACY1215. Furthermore, low-dose 35m effectively decreases LPS-induced IL-1 beta release by blocking the activation of NLRP3, indicating its potential as an orally active therapeutic agent for NLRP3-related diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Tinghui Shao, Yujia Xue, Mingming Fang
Summary: The study investigated the transcriptional regulation mechanism of Clca2 in cardiac fibrosis, revealing that the Twist1-HDAC1 complex can suppress the expression of Clca2 in cardiac fibroblasts, potentially leading to FMyT and cardiac fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sonali Bahl, Edward Seto
Summary: Histone deacetylases (HDACs) are enzymes that regulate cellular processes by removing acetyl groups from proteins. HDAC activities are regulated by various mechanisms, including posttranslational modifications like reversible phosphorylation. Dysregulation of HDACs can contribute to disease development, making it important to understand how reversible phosphorylation affects their functions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Urology & Nephrology
Paulina X. Medina X. Rangel, Elizabeth Cross, Chang Liu, Christopher E. E. Pedigo, Xuefei Tian, Elena Gutierrez-Calabres, Soichiro Nagata, Anupama Priyadarshini, Gabriel Lerner, Patricia Bunda, Sudhir Perincheri, Jianlei Gu, Hongyu Zhao, Ying Wang, Kazunori Inoue, Shuta Ishibe
Summary: Loss of Hdac1/2 in podocytes during development leads to sustained DNA damage, senescence, and loss of podocytes. HDACs play a crucial role in maintaining the normal glomerular filtration barrier and preventing premature senescence. The damaged podocytes secrete proinflammatory cytokines, growth factors, and matrix metalloproteinases, resulting in subsequent podocyte detachment and loss.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Agricultural Engineering
Xuefeng Lu, Tae Kyung Hyun
Summary: Post-translational histone modifications, such as histone acetylation, play key roles in regulating gene expression in plant growth, development, and stress responses. The research found that HDAC inhibitors led to hyperacetylation of histone H3, enhancing MeJA-induced ginsenoside production in ginseng adventitious roots. Additionally, the study identified specific PgHDACs that may serve as crucial factors in controlling MeJA-induced ginsenoside production.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Multidisciplinary Sciences
William Villiers, Audrey Kelly, Xiaohan He, James Kaufman-Cook, Abdurrahman Elbasir, Halima Bensmail, Paul Lavender, Richard Dillon, Borbala Mifsud, Cameron S. Osborne
Summary: The PML-RARA gene fusion is the characteristic driver of Acute Promyelocytic Leukaemia (APL) and is known to bind to the genome. Here, the authors characterise the impact of PML-RARA on gene regulation in APL cell lines and patient samples using transcriptomics, epigenomics, and machine learning.
NATURE COMMUNICATIONS
(2023)
Article
Critical Care Medicine
Yael Strulovici-Barel, Renat Shaykhiev, Jacqueline Salit, Ruba S. Deeb, Anja Krause, Robert J. Kaner, Thomas L. Vincent, Francisco Agosto-Perez, Guoqing Wang, Charleen Hollmann, Vignesh Shanmugam, Ahmad M. Almulla, Hisham Sattar, Mai Mahmoud, Jason G. Mezey, Steven S. Gross, Michelle R. Staudt, Matthew S. Walters, Ronald G. Crystal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Ruba S. Deeb, Matthew S. Walters, Yael Strulovici-Barel, Qiuying Chen, Steven S. Gross, Ronald G. Crystal
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2016)
Article
Cell & Tissue Engineering
Kazunori Gomi, Yongjiang Tang, Vanessa Arbelaez, Ronald G. Crystal, Matthew S. Walters
STEM CELL REVIEWS AND REPORTS
(2017)
Article
Cell & Tissue Engineering
Kazunori Gomi, Yongjiang Tang, Vanessa Arbelaez, Ronald G. Crystal, Matthew S. Walters
STEM CELL REVIEWS AND REPORTS
(2017)
Article
Critical Care Medicine
Wu-Lin Zuo, Sushila A. Shenoy, Sheng Li, Sarah L. O'Beirne, Yael Strulovici-Barel, Philip L. Leopold, Guoqing Wang, Michelle R. Staudt, Matthew S. Walters, Christopher Mason, Robert J. Kaner, Jason G. Mezey, Ronald G. Crystal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Multidisciplinary Sciences
Matthew S. Walters, Jacqueline Salit, Jin Hyun Ju, Michelle R. Staudt, Robert J. Kaner, Allison M. Rogalski, Teniola B. Sodeinde, Riyaad Rahim, Yael Strulovici-Barel, Jason G. Mezey, Ahmad M. Almulla, Hisham Sattar, Mai Mahmoud, Ronald G. Crystal
Article
Virology
Wenxin Wu, Wei Zhang, Lili Tian, Brent R. Brown, Matthew S. Walters, Jordan P. Metcalf
Article
Biochemistry & Molecular Biology
Manish Bodas, Andrew R. Moore, Bharathiraja Subramaniyan, Constantin Georgescu, Jonathan D. Wren, Willard M. Freeman, Brent R. Brown, Jordan P. Metcalf, Matthew S. Walters
Summary: This study found that NOTCH3 signaling pathway in cigarette smoke regulates goblet cell differentiation, ultimately affecting the pathophysiology of COPD.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ashish Saxena, Matthew S. Walters, Jae-Hung Shieh, Ling-Bo Shen, Kazunori Gomi, Robert J. Downey, Ronald G. Crystal, Malcolm A. S. Moore
Summary: The airway basal cells communicate with endothelial cells through exosome-enriched EVs, promoting cell survival via VEGFR2 activation and involvement of VEGFA. However, downstream signaling pathways involved in airway basal cell EVs may be distinct from other signaling pathways.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Bharathiraja Subramaniyan, Jason L. Larabee, Manish Bodas, Andrew R. Moore, Anthony W. G. Burgett, Dean A. Myers, Constantin Georgescu, Jonathan D. Wren, James F. Papin, Matthew S. Walters
Summary: The study reveals that SARS-CoV-2 infection in older individuals leads to an early proinflammatory response and a delayed interferon response, along with changes in genes and pathways associated with cell death and senescence.
Article
Cell Biology
Manish Bodas, Bharathiraja Subramaniyan, Andrew R. Moore, Jordan P. Metcalf, Sarah R. Ocanas, Willard M. Freeman, Constantin Georgescu, Jonathan D. Wren, Matthew S. Walters
Summary: The study reveals HEYL as a key regulator of airway epithelial differentiation downstream of NOTCH3 signaling. Expression level of HEYL in bronchial epithelial cells is closely related to cell differentiation capacity, and its overexpression can restore the differentiation capacity of COPD cells towards normal airway epithelium.
Letter
Biochemistry & Molecular Biology
Bharathiraja Subramaniyan, Jason L. Larabee, Manish Bodas, Andrew R. Moore, Anthony W. G. Burgett, James F. Papin, Matthew S. Walters
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Manish Bodas, Bharathiraja Subramaniyan, Harry Karmouty-Quintana, Peter F. Vitiello, Matthew S. Walters
Summary: The lung, as the respiratory organ of mammals, plays a crucial role in gas exchange and is regulated by the NOTCH signaling pathway. Notably, dysregulation of NOTCH3 signaling is associated with the development and pathophysiology of various adult lung diseases.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Guoqing Wang, Haixia Zhou, Yael Strulovici-Barel, Mohammed Al-Hijji, Xuemei Ou, Jacqueline Salit, Matthew S. Walters, Michelle R. Staudt, Robert J. Kaner, Ronald G. Crystal
Article
Respiratory System
Fumihiro Ogawa, Matthew S. Walters, Afrah Shafquat, Sarah L. O'Beirne, Robert J. Kaner, Jason G. Mezey, Haijun Zhang, Philip L. Leopold, Ronald G. Crystal
RESPIRATORY RESEARCH
(2019)