Review
Biochemistry & Molecular Biology
Amanda de Oliveira Lopes, Pedro do Nascimento Marinho, Leticia d'Ambrosio de Souza Medeiros, Vanessa Salete de Paula
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) is a virus containing oncogenes and proteins that play a crucial role in regulating cellular functions and leading to Kaposi's sarcoma. Some of these genes have the potential to be therapeutic targets for Kaposi's sarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Yuan Fang, Wenli Li, Ying Zhang, Chang Zhou, Huanwu Wu, Yiting Zhang, Tao Dai, Jinzhi Wang, Lei Wang, Tongqing Chen, Yulin Zhu, Linding Wang
Summary: The seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV) is high in Gansu, China, especially among certain ethnic groups and syphilis patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Virology
Lindsey Barrett, Lu Dai, Shanzhi Wang, Zhiqiang Qin
Summary: This article summarizes how KSHV utilizes extracellular vesicles (EVs) to create favorable environments for viral spread and persistence while evading immune responses. EVs play a significant role in the development and function of the immune system.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Qian Chen, Jiangtao Chen, Yuqing Li, Dawei Liu, Yan Zeng, Zheng Tian, Akbar Yunus, Yong Yang, Jie Lu, Xinghua Song, Yan Yuan
Summary: The prevalence of KSHV infection is significantly elevated in Uyghur osteosarcoma patients, with the virus being associated with some osteosarcomas. The study suggests that KSHV infection is a risk factor for osteosarcoma, representing a newly identified viral-associated endemic cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Dongdong Cao, Shuyuan Wu, Xiaolu Wang, Ying Li, Huiling Xu, Zemin Pan, Zhaofu Wu, Lei Yang, Xiaohua Tan, Dongmei Li
Summary: KSHV infection promotes cell proliferation and enhances the expression of Notch signaling pathway proteins in SH-SY5Y cells, potentially contributing to the increased cell proliferation.
CANCER CELL INTERNATIONAL
(2021)
Article
Microbiology
Yuki Iwaisako, Tadashi Watanabe, Mizuki Hanajiri, Yuichi Sekine, Masahiro Fujimuro
Summary: The KSHV ORF7 plays a key role in viral replication by regulating capsid formation, maintaining viral production, and promoting lytic replication through interactions with other terminase components.
Article
Biochemistry & Molecular Biology
Yujun Liu, Yuan-Chuan Chen, Bin Yan, Fenyong Liu
Summary: In this study, ribozymes derived from RNase P catalytic RNA were engineered to target the mRNA encoding KSHV RTA. The functional ribozyme F-RTA efficiently sliced the RTA mRNA and suppressed KSHV production and gene expression. This study demonstrates the potential of RNase P ribozymes as a therapy against KSHV.
Article
Virology
Qinqin Sun, Fan Wang, Qingyang Chen, Ronit Sarid, Xiaojuan Li, Ersheng Kuang
Summary: The lytic replication of Kaposi's sarcoma-associated herpesvirus (KSHV) is enhanced by ORF45, which upregulates the expression of ATF4 and LAMP3, leading to reprogrammed cellular transcription and translation that supports viral protein production.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Tate Tabtieng, Rachel C. Lent, Machika Kaku, Alvaro Monago Sanchez, Marta Maria Gaglia
Summary: Type I interferons play a crucial role in infectious and inflammatory diseases. Viruses have developed strategies to suppress the production of type I interferons, and apoptotic caspases have emerged as important regulators of type I interferon signaling. This study reveals that caspase activity inhibits the DNA sensor cGAS during KSHV infection, blocking the antiviral type I interferon response. These findings provide insights into the mechanisms of viral immune evasion and can inform targeted therapeutic strategies for viral infections.
Article
Infectious Diseases
Jinchuan Shi, Gaoxiang Ying, Zhongdong Zhang
Summary: In the treatment of AIDS patients with Kaposi's sarcoma, the reconstitution of immune function and consecutive chemotherapy with doxorubicin liposome are crucial. Early recognition and histopathological verification of general symptoms such as thrombocytopenia and hemorrhagic purple papules in AIDS patients are necessary to achieve early diagnosis of KS and timely clinical intervention.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Bojan F. Hoernich, Anna K. Grosskopf, Candice J. Dcosta, Sarah Schlagowski, Alexander S. Hahn
Summary: IFITMs are broad-spectrum antiviral proteins that inhibit the entry of enveloped viruses. IFITM1 restricts KSHV and RRV infection in some cells by reducing membrane fusogenicity, but not in primary umbilical vein endothelial cells. High constitutive IFITM expression can potently inhibit IAV glycoprotein-driven infection of non-lung cells.
Article
Virology
Shun Iida, Sohtaro Mine, Keiji Ueda, Tadaki Suzuki, Hideki Hasegawa, Harutaka Katano
Summary: The histone deacetylase inhibitor SBHA was found to efficiently induce KSHV reactivation and apoptosis in PEL cells, suggesting its potential as a tool for KSHV reactivation induction and a novel therapeutic strategy against PEL.
JOURNAL OF VIROLOGY
(2021)
Review
Oncology
Sophie Grabar, Dominique Costagliola
Summary: An air mattress is a non-breathable sleeping aid commonly used for camping or guests' accommodation.
Article
Virology
Kevin Brackett, Ameera Mungale, Mary Lopez-Isidro, Duncan A. Proctor, Guillermo Najarro, Carolina Arias
Summary: CRISPR interference (CRISPRi) can efficiently silence latent and lytic viral genes of Kaposi's sarcoma-associated herpesvirus (KSHV) in epithelial and B-cells, providing a functional genomics tool for studying virus-host interactions.
Article
Virology
Xin Zhang, Qiwen Fang, Sibo Zhu, Xuefu Wu, Huangbo Yuan, Zhenqiu Liu, Yiyun Xu, Tao Chen, Yan Zeng, Tiejun Zhang
Summary: This study aimed to investigate the genetic and environmental predisposing factors for KSHV infection among the Uygur population in Xinjiang, China. The findings revealed that sweet-food preference, coronary heart disease, and genetic variation in HLA-DQB1*06:09 were strongly associated with KSHV infection.
JOURNAL OF MEDICAL VIROLOGY
(2022)