Article
Microbiology
Makoto Ohashi, Mitchell Hayes, Kyle McChesney, Eric Johannsen
Summary: EBV infection can lead to specific types of lymphoma and some epithelial cancers. In vitro, EBV infection of resting B-lymphocytes drives them to proliferate as lymphoblastoid cell lines, serving as a model for studying EBV lymphomagenesis. This study reveals that interaction between EBNA3C and CtBP results in EBNA3C-mediated upregulation.
Article
Oncology
Samantha S. Soldan, Emma M. Anderson, Drew M. Frase, Yue Zhang, Lisa B. Caruso, Yin Wang, Julianna S. Deakyne, Benjamin E. Gewurz, Italo Tempera, Paul M. Lieberman, Troy E. Messick
Summary: The study demonstrated that the EBNA1 inhibitor VK-1727 selectively inhibited cell growth in EBV-positive gastric carcinoma and reduced tumor growth in animal models, but not in EBV-negative gastric carcinoma. Short-term treatment tended to activate viral genes, while long-term treatment resulted in significant decrease in viral gene expression.
Article
Cell Biology
Xiaohua Huang, Bin Wang, Runji Chen, Shuping Zhong, Fenfei Gao, Yanmei Zhang, Yongdong Niu, Congzhu Li, Ganggang Shi
Summary: The study aimed to assess the mechanism of FXR in cervical cancer and found that FXR reduces cell viability, induces apoptosis, and promotes cell cycle arrest. FXR inhibits cervical cancer by upregulating SHP, MDM2, and p53.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kester Mo Henningsen, Valentina Manzini, Anna Magerhans, Sabrina Gerber, Matthias Dobbelstein
Summary: MDM2 can remove p53 from promoters by rapidly terminating its interactions with chromatin in a ubiquitin-dependent manner, in addition to its antagonism through covering the transactivation domain and destabilization.
Article
Biochemistry & Molecular Biology
Viktoria K. Ilic, Olga Egorova, Ernest Tsang, Milena Gatto, Yi Wen, Yong Zhao, Yi Sheng
Summary: The proto-oncogene MDM2 is frequently amplified in many human cancers and its overexpression is associated with poor prognosis. MDM2 shows oncogenic activity by negatively regulating tumor suppressor p53 and proteins involved in DNA repair, cell cycle control, and apoptosis pathways. Inhibition of MDM2 activity has been pursued as an attractive direction for anti-cancer therapeutics. This study identified a biflavonoid compound Hinokiflavone as a promising candidate compound targeting MDM2. Hinokiflavone was shown to bind the MDM2-MDMX RING domain and inhibit MDM2-mediated ubiquitination in vitro. Hinokiflavone treatment downregulated MDM2 and MDMX and induced apoptosis in various cancer cell lines. Hinokiflavone demonstrated tumor-suppressive activity that is both p53-dependent and -independent.
Article
Immunology
Yiran Qu, Bingyang Zhang, Yingli Wang, Shuang Yin, Jordan L. Pederick, John B. Bruning, Yan Sun, Anton Middelberg, Jingxiu Bi
Summary: The study investigated the relationship between insertion sites in ferritin (N-terminus and C-terminus) and immune responses, finding that C-terminus insertion resulted in a stronger cell-mediated immune response than N-terminus insertion. This research provides new insights into the development of ferritin nanoparticle vaccines.
Article
Gastroenterology & Hepatology
Hui Song, Yan Zhang, Juanjuan Liu, Wen Liu, Bing Luo
Summary: The study revealed a new mechanism of EBV in regulating the expression of DNMT3a in EBV-associated gastric carcinoma. Targeting the EBNA1/E2F1/DNMT3a axis could be a potential therapeutic strategy for EBVaGC with high DNMT3a expression.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Cell Biology
Yunshan Liu, Beibei Cao, Liqiao Hu, Jingjing Ye, Wei Tian, Xiaojing He
Summary: This study elucidated the molecular link between MAGE-C2 and two major E3 systems, MDM2 and TRIM28, in p53 ubiquitination. MAGE-C2 inhibits MDM2 activity on p53 ubiquitination through direct interaction, while TRIM28 acts as a binding partner of MAGE-C2 and competes for MDM2 interaction, thereby promoting p53 ubiquitination. MAGE-C2 functions as a potential inhibitor of MDM2, and TRIM28 is a vital regulator for MAGE-C2 function in p53 protein level and cell proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Miao Yan, Xin Li, Jinbao Gu, Guojun Gao, Ziyu Wu, Peng Xue
Summary: In this study, it was found that yuanhuacine can inhibit the proliferation and migration of prostate cancer cells, and induce apoptosis. The study also found that yuanhuacine suppresses tumor growth by inhibiting the MDM2/p53 signaling pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Microbiology
Jayaraju Dheekollu, Andreas Wiedmer, Samantha S. Soldan, Leonardo Josue Castro-Munoz, Christopher Chen, Hsin-Yao Tang, David W. Speicher, Paul M. Lieberman
Summary: EBV is associated with various malignancies and autoimmune disease. EBNA1 is essential for viral episome maintenance and DNA replication. PLOD1 interacts with EBNA1, regulates its protein stability, and plays a role in viral persistence and DNA replication.
Article
Clinical Neurology
Brit Ellen Rod, Stig Wergeland, Kjetil Bjornevik, Trygve Holmoy, Elling Ulvestad, Gro Njolstad, Kjell-Morten Myhr, Oivind Torkildsen
Summary: B cell depletion therapy leads to a decrease in EBNA1 IgG levels and an increase in VCA IgG levels in patients with multiple sclerosis (MS). This supports the hypothesis that the mechanism of action for B cell depletion therapy may be mediated by effects on EBV infection.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Oncology
Rati Lama, Chao Xu, Samuel L. Galster, Javier Querol-Garcia, Scott Portwood, Cory K. Mavis, Federico M. Ruiz, Diana Martin, Jin Wu, Marianna C. Giorgi, Jill Bargonetti, Eunice S. Wang, Francisco J. Hernandez-Ilizaliturri, Gerald B. Koudelka, Sherry R. Chemler, Ines G. Munoz, Xinjiang Wang
Summary: This study identifies MMRi62 as a novel MDM2-MDM4-targeting agent that can induce apoptosis in leukemia cells, including those with non-functional p53.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Christophe Le Clorennec, Karen Lee, Yuchen Huo, Peter E. Zage
Summary: USP7 inhibition is a promising therapeutic strategy for high-risk and relapsed neuroblastoma (NB) in children. Inhibiting USP7 activates the p53 pathway, induces apoptosis in NB cells, and reduces N-myc protein levels. The combination of USP7 and MDM2 inhibition shows enhanced efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Michihisa Kono, Takumi Kumai, Ryusuke Hayashi, Hidekiyo Yamaki, Hiroki Komatsuda, Risa Wakisaka, Toshihiro Nagato, Takayuki Ohkuri, Akemi Kosaka, Kenzo Ohara, Kan Kishibe, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Esteban Celis, Hiroya Kobayashi, Yasuaki Harabuchi
Summary: The study identified an MDM2-derived peptide epitope that triggered specific T cell responses, leading to immune responses that directly killed tumor cells; MDM2 was found to be expressed in head and neck cancer patients with poor prognosis, indicating potential benefits of the MDM2 peptide for these patients; Experimental evidence suggested that combining MDM2 inhibitors with MDM2 peptide therapeutic vaccines could represent an effective immunologic strategy for treating cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Virology
Xing Zhang, Yan Zhang, Wen Liu, Bing Luo
Summary: Protein post-translational modifications (PTMs) are reversible processes that regulate the function of target proteins without altering their sequences. EBV, a ubiquitous herpesvirus, can manipulate host ubiquitination, SUMOylation, and phosphorylation to establish a latent infection or favor viral replication and pathogenesis. Understanding the mechanisms by which EBV products manipulate host PTMs is crucial for exploring new therapeutic strategies against EBV-associated diseases.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Abhik Saha, Hem C. Jha, Santosh K. Upadhyay, Erle S. Robertson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Microbiology
Yonggang Pei, Shuvomoy Banerjee, Zhiguo Sun, Hem Chandra Jha, Abhik Saha, Erle S. Robertson
Review
Microbiology
Shaoni Bhattacharjee, Shatadru Ghosh Roy, Priyanka Bose, Abhik Saha
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Cell Biology
Shaoni Bhattacharjee, Priyanka Bose, Krishna Patel, Shatadru Ghosh Roy, Chandrima Gain, Harsha Gowda, Erle S. Robertson, Abhik Saha
CELL DEATH & DISEASE
(2018)
Review
Microbiology
Abhik Saha, Erle S. Robertson
FUTURE MICROBIOLOGY
(2013)
Article
Virology
Hem Chandra Jha, Santosh Kumar Upadhyay, Mahadesh A. J. Prasad, Jie Lu, Qiliang Cai, Abhik Saha, Erle S. Robertson
JOURNAL OF VIROLOGY
(2013)
Article
Virology
Hem Chandra Jha, Jie Lu, Abhik Saha, Qiliang Cai, Shuvomoy Banerjee, Mahadesh A. J. Prasad, Erle S. Robertson
JOURNAL OF VIROLOGY
(2013)
Article
Virology
Hem C. Jha, Mahadesh A. J. Prasad, Abhik Saha, Shuvomoy Banerjee, Jie Lu, Erle S. Robertson
JOURNAL OF VIROLOGY
(2014)
Article
Oncology
Richard K. Dzeng, Hem Chandra Jha, Jie Lu, Abhik Saha, Sagarika Banerjee, Erie S. Robertson
MOLECULAR ONCOLOGY
(2015)
Article
Microbiology
Jie Lu, Subhash C. Verma, Qiliang Cai, Abhik Saha, Richard Kuo Dzeng, Erle S. Robertson
Article
Microbiology
Shuvomoy Banerjee, Jie Lu, Qiliang Cai, Abhik Saha, Hem Chandra Jha, Richard Kuo Dzeng, Erle S. Robertson
Article
Microbiology
Shengwei Zhang, Yonggang Pei, Fengchao Lang, Kunfeng Sun, Rajnish Kumar Singh, Zachary L. Lamplugh, Abhik Saha, Erle S. Robertson
Article
Microbiology
Chandrima Gain, Samaresh Malik, Shaoni Bhattacharjee, Arijit Ghosh, Erle S. Robertson, Benu Brata Das, Abhik Saha
Article
Biochemistry & Molecular Biology
Chandrima Gain, Aparna Sarkar, Shrea Bural, Moumita Rakshit, Jeet Banerjee, Ankita Dey, Nabendu Biswas, Gandhi K. Kar, Abhik Saha
Summary: Our study identified two thiophene analogues - compounds 48 and 52, with nearly 4 times greater anti-proliferative efficiency on breast cancer cells compared to natural tanshinones. These compounds induced autophagy-mediated cell death, transcriptionally activated several autophagy genes, and death regulators, supporting their potential as promising leads for further development as anticancer agents by modulating autophagy mechanism.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Correction
Virology
Abhik Saha, Masanao Murakami, Pankaj Kumar, Bharat Bajaj, Karen Sims, Erle S. Robertson
JOURNAL OF VIROLOGY
(2021)