Article
Oncology
Ziyuan Shen, Lingling Hu, Mingkang Yao, Chenlu He, Qinhua Liu, Fei Wang, Weiying Gu, Ying Wang, Manyu Dong, Taigang Zhu, Ting Yin, Fei Li, Yingliang Jin, Shuiping Huang, Hao Zhang, Wei Sang
Summary: A retrospective multicenter study of 454 lymphoma patients found that elevated EBV DNA load can affect the prognosis of NKTL, FL, and DLBCL. The integration of EBER status and EBV DNA can differentiate the prognosis of HL patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Paul J. Farrell, Robert E. White
Summary: The incidence of diseases associated with EBV infection varies greatly in different parts of the world, which may be influenced by the variation in the virus genome. This article describes the main forms of EBV genome sequence variation and the potential contribution of these variations to disease development. Polymorphisms or deletions in the EBV genome can also serve as useful markers for disease monitoring. If certain strains of EBV are proven to be more pathogenic than others, immunization against these pathogenic strains may be valuable.
Article
Microbiology
Yiping Wang, Nathan Ungerleider, Brett A. Hoffman, Mehmet Kara, Paul J. Farrell, Erik K. Flemington, Nara Lee, Scott A. Tibbetts
Summary: Oncogenic gammaherpesviruses employ various strategies to colonize the host, including the expression of noncoding RNAs (ncRNAs). The specific functions of EBV-encoded RNA 1 and 2 (EBER1 and EBER2) have remained largely unknown, despite extensive investigation. This study reveals that an EBV EBER2 variant highly associated with B cell lymphoma significantly promotes expansion of the infected B cell pool in vivo, coinciding with altered B cell differentiation.
Article
Oncology
Atsushi Kondo, Aya Shinozaki-Ushiku, Hirofumi Rokutan, Akiko Kunita, Masako Ikemura, Hiroharu Yamashita, Yasuyuki Seto, Genta Nagae, Kenji Tatsuno, Hiroyuki Aburatani, Daizo Koinuma, Tetsuo Ushiku
Summary: In this study, we report eight cases of EBV-associated gastric carcinoma (EBVaGC) with heterogenous EBER expression. Through detailed histological assessment and genetic/epigenetic analysis, we identified collision tumors of different origins in two patients and shared alterations between EBER-positive and -negative components in the other six patients. This study provides important insights into the histological features and genetic/epigenetic alterations in EBVaGC and the clinical significance of losing EBV in tumor progression and immune evasion.
JOURNAL OF PATHOLOGY
(2023)
Article
Medicine, Research & Experimental
Meichun Zeng, Qingjun Jia, Jingjing Chen, Liming Xu, Li Xie, Qinglin Cheng, Qingchun Li, Ming Xiao, Zijian Fang
Summary: The relationship between plasma EBV-DNA load (PEDL) and Epstein-Barr virus (EBV)-encoded small RNA (EBER) during the early treatment of lymphoma is not well-established. This study found that although EBER affects the levels of PEDL, there is poor concordance between EBER and qualitative analysis of PEDL (qPEDL).
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Microbiology
Lilit Tonoyan, Marlene Chevalier, Severine Vincent-Bugnas, Robert Marsault, Alain Doglio
Summary: Periodontitis is a major threat to oral health, associated with tooth loss and systemic diseases, with a new paradigm suggesting a viral-bacterial combination as a key factor. Research on the Epstein-Barr virus (EBV) may contribute to advancing periodontitis research and controlling the disease. Innovative technologies are being explored to detect and diagnose EBV in periodontitis for better understanding and management of the condition.
Article
Multidisciplinary Sciences
Yoshimi Enose-Akahata, Limin Wang, Fahad Almsned, Kory R. Johnson, Yair Mina, Joan Ohayon, Xin Wei Wang, Steven Jacobson
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), and the cause of MS remains unknown. This study investigated the antibody responses against various viruses in the cerebrospinal fluid (CSF) and serum of MS patients, and found significant differences compared to healthy volunteers, as well as a pattern of antibody responses against multiple viruses, including Epstein-Barr virus. These findings indicate that virus-specific antibody signatures might reflect the disease-associated inflammatory milieu in the CSF of patients with neuroinflammatory diseases.
Article
Multidisciplinary Sciences
Zhe Li, Francesco Baccianti, Susanne Delecluse, Ming-Han Tsai, Anatoliy Shumilov, Xianliang Cheng, Sicong Ma, Ingrid Hoffmann, Remy Poirey, Henri-Jacques Delecluse
Summary: The viral noncoding RNA EBER2 accelerates B cell growth by potentiating expression of the UCHL1 deubiquitinase, even in Burkitt's lymphoma cells that do not express the virus's known oncogenes. This study identifies a direct cellular target of a viral noncoding RNA that is likely crucial for EBV's oncogenic properties.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Immunology
Wei Xia, Honglin Chen, Yiwei Feng, Nan Shi, Zongjian Huang, Qingyuan Feng, Xu Jiang, Guangyao He, Mao Xie, Yongjin Lai, Zhi Wang, Xiang Yi, Anzhou Tang
Summary: The study demonstrates that the tree shrew is a suitable animal model for evaluating the mechanisms of EBV infection and for developing vaccines and therapeutic drugs against EBV. This is due to its close phylogenetic relationship with humans, making it a valuable tool for studying viral infections and human diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
Article
Biochemistry & Molecular Biology
Tian-Liang Xia, Xingyang Li, Xueping Wang, Yun-Jia Zhu, Hua Zhang, Weisheng Cheng, Mei-Ling Chen, Ying Ye, Yan Li, Ao Zhang, Dan-Ling Dai, Qian-Ying Zhu, Li Yuan, Jian Zheng, Huilin Huang, Si-Qi Chen, Zhi-Wen Xiao, Hong-Bo Wang, Gaurab Roy, Qian Zhong, Dongxin Lin, Yi-Xin Zeng, Jinkai Wang, Bo Zhao, Benjamin E. Gewurz, Jianjun Chen, Zhixiang Zuo, Mu-Sheng Zeng
Summary: This study demonstrates that EBV transcripts exhibit differential m(6)A modification in human NPC biopsies and cells at different infection stages, and the m(6)A-modified EBV transcripts are recognized and destabilized by the YTHDF1 protein, leading to suppression of EBV infection and replication. YTHDF1 accelerates viral RNA decapping and mediates RNA decay, thereby downregulating the expression of EBV genes post-transcriptionally.
Article
Biochemistry & Molecular Biology
Xubing Long, Jing Yang, Xiaolin Zhang, Ziwei Yang, Yang Li, Fan Wang, Xiaojuan Li, Ersheng Kuang
Summary: The study reveals that Epstein-Barr virus lytic replication inhibits inflammasome activation through the immediate-early protein BRLF1, leading to altered immune responses in T cells and NK cells.
Review
Biochemistry & Molecular Biology
Zbigniew Wyzewski, Matylda Barbara Mielcarska, Karolina Paulina Gregorczyk-Zboroch, Anna Myszka
Summary: Epstein-Barr virus (EBV) is a widely distributed virus in the human population, capable of establishing latent infection and exerting anti-apoptotic effects. Its anti-apoptotic products increase the viability of infected cells and confer resistance to chemotherapy, contributing to the development of various EBV-associated diseases. Additionally, EBV-encoded small RNAs and microRNAs play an important role in promoting the survival of malignant cells and influencing the expression and activity of Bcl-2 protein family members.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Li Chang, Chaoyin Zhang, Jingjing Lu, Jiahui Shen, Krishna Hamal, Donghua Liu
Summary: The purpose of this study was to investigate the clinical and pathological features, laboratory markers, therapeutic options, and risk factors indicating poor prognosis of hydroa vacciniforme-like lymphoproliferative disorder (HVLPD). Seven patients with HVLPD were included in this study. The results showed that the main clinical manifestations were papulovesicular lesions and ulcers on the face, neck, or trunk, and three of the deceased patients had significant facial edema, deep body necrosis, and ulceration. All patients tested positive for CD3 and EBER. The study also found that high levels of lgE, plasma EBV DNA, IFN-gamma, and TNF-alpha cytokines, decreased hemoglobin level, strongly positive expression of TIA-1, high Ki67 proliferation index, and positive TCR gene rearrangement were indicators of poor prognosis.
INFECTION AND DRUG RESISTANCE
(2023)