Article
Immunology
Ana MicaelaCarnaz Simoes, Morten Orebo Holmstrom, Pia Aehnlich, Anne Rahbech, Aneta Radziwon-Balicka, Carlos Zamora, Tobias Wirenfeldt Klausen, Vibe Skov, Lasse Kjaer, Christina Ellervik, Daniel El Fassi, Silvia Vidal, Hans Carl Hasselbalch, Mads Hald Andersen, Per Thor Straten
Summary: This study investigates the frequencies of circulating platelet (PLT)-lymphocyte aggregates in myeloproliferative neoplasms (MPN) patients and the impact of PLT binding on CD8 T cell function. The results show significantly higher frequencies of PLT-CD8 T cell aggregates in MPN patients and reduced proliferation and cytotoxic capacity in PLT-bound CD8 T cells. The findings suggest compromised CD8 T cell responses in MPN patients due to PLT binding, possibly contributing to disease progression and increased susceptibility to infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ian Baudi, Keigo Kawashima, Masanori Isogawa
Summary: Hepatitis B virus (HBV) is a major cause of liver-related morbidity and mortality, with chronic hepatitis potentially progressing to cirrhosis and cancer. CD8+ T cells play a central role in clearing acute HBV infection, with weak CD8+ T cell responses in chronic hepatitis B (CHB) possibly due to multifaceted mechanisms and immunoregulatory cell populations in the liver. Studies suggest that genetic and epigenetic changes in dysfunctional CD8+ T cells may be targets for immunotherapy to treat CHB.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Daisuke Chujo, Akitsu Kawabe, Maya Matsushita, Chiharu Tsutsumi, Fumitaka Haseda, Akihisa Imagawa, Toshiaki Hanafusa, Kohjiro Ueki, Hiroshi Kajio, Kunimasa Yagi, Kazuyuki Tobe, Masayuki Shimoda
Summary: The study revealed significantly upregulated IGRP and ZnT8-specific CD8+ T cell responses in FT1D and AT1D patients, with higher frequencies of IGRP-specific Tc1 cells in the FT1D group. These findings suggest a significant role of IGRP-specific CD8+ T cells in the pathogenesis of FT1D.
CLINICAL IMMUNOLOGY
(2021)
Article
Hematology
Yun Deng, Bithi Chatterjee, Kyra Zens, Hana Zdimerova, Anne Muller, Patrick Schuhmachers, Laure-Anne Ligeon, Antonino Bongiovanni, Riccarda Capaul, Andrea Zbinden, Angelika Holler, Hans Stauss, Wolfgang Hammerschmidt, Christian Muenz
Summary: Deficiencies in the costimulatory molecule CD27 and its ligand CD70 can lead to uncontrolled EBV infection, with CD27 blockade affecting only certain EBV-specific CD8(+) T-cell responses, indicating that CD27 is not required for all CD8(+) T-cell expansions and cytotoxicity.
Article
Immunology
Maud Wilhelm, Amandeep Kaur, Marion Wernli, Hans H. Hirsch
Summary: Using synthetic 27mer-long BKPyV peptides, different types of antigen-presenting cells, and CD4 T cells, BKPyV-specific CD8 T cell responses were expanded, providing a novel approach for vaccination and adoptive T-cell therapies for patients before and after kidney transplantation.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Mark A. Pilkinton, Wyatt J. McDonnell, Louise Barnett, Abha Chopra, Rama Gangula, Katie D. White, Shay Leary, Jennifer Currenti, Silvana Gaudieri, Simon A. Mallal, Spyros A. Kalams
Summary: Cellular immune responses to Gag are associated with improved HIV control, with CD8(+) T cell response dominated by a few unique TCRs and CD4(+) T cell response displaying a more diverse TCR repertoire. Greater TCR diversity in CD4(+) T cells may limit HIV genetic diversity during chronic infection.
JOURNAL OF VIROLOGY
(2021)
Article
Medicine, Research & Experimental
Rachel L. Rutishauser, Christian Deo T. Deguit, Joseph Hiatt, Franziska Blaeschke, Theodore L. Roth, Lynn Wang, Kyle A. Raymond, Carly E. Starke, Joseph C. Mudd, Wenxuan Chen, Carolyn Smullin, Rodrigo Matus-Nicodemos, Rebecca Hoh, Melissa Krone, Frederick M. Hecht, Christopher D. Pilcher, Jeffrey N. Martin, Richard A. Koup, Daniel C. Douek, Jason M. Brenchley, Rafick-Pierre Sekaly, Satish K. Pillai, Alexander Marson, Steven G. Deeks, Joseph M. McCune, Peter W. Hunt
Summary: The transcription factor TCF-1 plays a crucial role in regulating the memory properties and expansion capacity of virus-specific CD8(+) T cells, which are important for controlling HIV infection. Increasing TCF-1 levels may enhance the secondary expansion capacity of HIV-specific CD8(+) T cells.
Article
Immunology
Michiel van Gent, Werner J. D. Ouwendijk, Victoria L. Campbell, Kerry J. Laing, Georges M. G. M. Verjans, David M. Koelle
Summary: This study suggests that VZV-specific CD8 T-cells play a limited role in maintaining latent infection of varicella-zoster virus in human trigeminal ganglia.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Gastroenterology & Hepatology
Ajinkya Pattekar, Lena S. Mayer, Chi Wai Lau, Chengyang Liu, Olesya Palko, Meenakshi Bewtra, Hpap Consortium, Lisa C. Lindesmith, Paul D. Brewer-Jensen, Ralph S. Baric, Michael R. Betts, Ali Naji, E. John Wherry, Vesselin T. Tomov
Summary: The study identified immune correlates of NoV protection and persistence and defined the breadth, distribution, and properties of human NoV-specific T-cell immunity, especially in the intestinal mucosa. These findings can guide the development of future vaccines and novel cellular therapeutics.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Alex Olvera, Samandhy Cedeno, Anuska Llano, Beatriz Mothe, Jorge Sanchez, Gemma Arsequell, Christian Brander
Summary: Post-translational protein modifications, particularly glycosylation, may impact T cell epitope recognition presented by HLA molecules, but this aspect has been overlooked in HIV research. Studies demonstrated that glycosylation can affect T cell recognition of viral peptides in individuals with chronic HIV infection, indicating the potential importance of glyco-epitope specific T cell immunity in understanding host immune responses against viral infections. New methodologies are needed to accurately assess the role of glycosylation in altering T cell immunity to viral infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Manuelle Viguier, Corine Perals, Beatrice Poirier, Maxime Battistella, Francois Aubin, Herve Bachelez, Jean-Luc Pretet, Tarik Gheit, Massimo Tommasino, Antoine Touze, Marie-Lise Gougeon, Nicolas Fazilleau
Summary: Lichen planus (LP) is a chronic inflammatory disease characterized by CD8(+) T-cell infiltrate, and HPV16-specific CD8(+) T-cells are involved in different clinical forms of LP. Lichen sclerosus et atrophicus (LSA) has a different immune response, with oligoclonal TCRVss6(+) CTL repertoire.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Oncology
Juan Estrada, Jinghui Zhan, Petia Mitchell, Jonathan Werner, Pedro J. Beltran, Jason DeVoss, Jing Qing, Keegan S. Cooke
Summary: In a mouse tumor model, combination treatment with OncoVEX(mGM-CSF) and checkpoint inhibitors led to increased tumor growth inhibition, reduced lung metastases, and prolonged animal survival. OncoVEX(mGM-CSF) induced both neoantigen-specific and tumor antigen-specific T-cell responses. These findings suggest that the combination of T-VEC and checkpoint inhibition may be effective in treating patients with advanced melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Dalila Mele, Anna Calastri, Eugenia Maiorano, Antonella Cerino, Michele Sachs, Barbara Oliviero, Stefania Mantovani, Fausto Baldanti, Raffaele Bruno, Marco Benazzo, Alba Grifoni, Alessandro Sette, Mario U. Mondelli, Stefania Varchetta
Summary: Patients with SARS-CoV-2-induced OTD develop highly functional virus-specific CD4(+) and CD8(+) T cells during the symptomatic phase of the disease, suggesting that robust and coordinated T-cell responses provide protection against extension of COVID-19 to the lower respiratory tract.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Sebastian Klein, Jasmin Mischke, Finn Beruldsen, Immo Prinz, Dinler A. Antunes, Markus Cornberg, Anke R. M. Kraft
Summary: A hallmark of chronic viral infections is exhausted antigen-specific CD8(+) T cell responses and the persistence of the virus in the immune system. This study aimed to examine the variability of epitope-specific T cell exhaustion and its relationship to T cell receptor (TCR) repertoire in a chronic setting with immune checkpoint inhibitor therapy. The results showed that there were individual and independent responses within one immune response, with different levels of exhaustion and TCR repertoire diversity. Additionally, the study revealed that immune checkpoint inhibitor therapy had heterogeneous effects on the TCR repertoire of different epitope-specific T cell responses. These findings have important implications for therapeutic approaches targeting chronic viral infections.
Article
Biochemistry & Molecular Biology
Marta Gomez-Perosanz, Jose L. Sanchez-Trincado, Miguel Fernandez-Arquero, John Sidney, Alessandro Sette, Esther M. Lafuente, Pedro A. Reche
Summary: This study identified and characterized 23 conserved HRV-specific CD8 T cell epitopes on PBMCs from 14 HLA I typed subjects, confirming peptide-specific IFN gamma production and binding to the relevant HLA I for nine of these epitopes. The study also validated cytotoxicity mediated by A*02:01-restricted epitopes and discovered an unusually long 16-mer epitope peptide restricted by A*02:01. These HRV-specific CD8 T cell epitopes are expected to elicit CD8 T cell responses in up to 87% of the population and could be crucial for developing an HRV vaccine.