Article
Immunology
Yana Hackler, Frank Siebenhaar, Max Loehning, Marcus Maurer, Melba Munoz
Summary: MCs play a critical role in the activation and expansion of virus-specific CD8(+) T cells through proper dendritic cell (DC) activation, and are essential for antiviral functions during viral infections. Depletion of MCs impairs CD8(+) T cell effector phenotype, antiviral cytokine production, and DC activation, resulting in increased viral loads and reduced type-I interferon levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Neda Feizi, Chiara Focaccetti, Ilenia Pacella, Gloria Tucci, Alessandra Rossi, Massimo Costanza, Rosetta Pedotti, John Sidney, Alessandro Sette, Claudia La Rocca, Claudio Procaccini, Giuseppe Matarese, Vincenzo Barnaba, Silvia Piconese
Summary: The study demonstrates that immune responses to cryptic apoptosis-associated epitopes (AEs) may contribute to immunopathology in neuroinflammation, as shown in a mouse model of MS (EAE). The presence of AE-specific CD8(+) T cells, their physiological control, and their exacerbation of disease severity when immunized with AEs during EAE induction were observed, supporting the role of AE-specific autoimmunity in neuroinflammation.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Raphael Kuhn, Ioana Sandu, Andreas Agrafiotis, Kai-Lin Hong, Danielle Shlesinger, Daniel Neimeier, Doron Merkler, Annette Oxenius, Sai T. Reddy, Alexander Yermanos
Summary: CD8+ T cells play a crucial role in viral infections and exhibit diverse phenotypes and effector functions. By analyzing the TCR repertoire and transcriptome of virus-specific CD8 T cells in murine models, we identified infection-specific populations corresponding to different phenotypes. Chronic and latent infections resulted in a higher proportion of clonally expanded T cells compared to acute infection. We also observed a relationship between transcriptional heterogeneity and clonal expansion.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Marco Kunzli, Stephen D. O'Flanagan, Madeleine LaRue, Poulami Talukder, Thamotharampillai Dileepan, J. Michael Stolley, Andrew G. Soerens, Clare F. Quarnstrom, Sathi Wijeyesinghe, Yanqi Ye, Justine S. McPartlan, Jason S. Mitchell, Christian W. Mandl, Richard Vile, Marc K. Jenkins, Rafi Ahmed, Vaiva Vezys, Jasdave S. Chahal, David Masopust
Summary: The routes of mRNA vaccination can influence humoral and cell-mediated immunity, with intramuscular vaccination establishing lung TRM and intranasal vaccination augmenting respiratory mucosal immunity. Combining intramuscular vaccination with intranasal boost can achieve high levels of both circulating T cell memory and lung TRM.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
David R. Collins, Jonathan M. Urbach, Zachary J. Racenet, Umar Arshad, Karen A. Power, Ruchi M. Newman, Geetha H. Mylvaganam, Ngoc L. Ly, Xiaodong Lian, Anna Rull, Yelizaveta Rassadkina, Adrienne G. Yanez, Michael J. Peluso, Steven G. Deeks, Francesc Vidal, Mathias Lichterfeld, Xu G. Yu, Gaurav D. Gaiha, Todd M. Allen, Bruce D. Walker
Summary: Selective functional impairment of HIV-specific CD8(+) T cells may be prognostic of aborted HIV control.
Article
Immunology
Ignacio Juarez, Shi Su, Zachary T. Herbert, John R. Teijaro, Vaishali R. Moulton
Summary: SRSF1 plays an essential role in the homeostasis and function of CD8 T cells, controlling their numbers, proliferative capacity, and cytotoxic function. It is also involved in the immune response to viral infection, regulating multiple signaling pathways in the transcriptome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Willemijn van der Wulp, Dennis F. G. Remst, Michel G. D. Kester, Renate S. Hagedoorn, Paul W. H. I. Parren, Sander I. van Kasteren, Janine Schuurman, Rob C. Hoeben, Maaike E. Ressing, Boris Bleijlevens, Mirjam H. M. Heemskerk
Summary: The antibody-epitope conjugates (AECs) are a promising new therapeutic strategy that redirects virus-specific T-cells towards cancer cells. This study demonstrates that AECs with epitopes fused to the heavy chain of antibodies can result in higher levels of T-cell activation compared to AECs with epitopes fused to the light chain. Furthermore, these AECs can efficiently deliver the epitope to different cancer cell lines and reduce tumor burden in vivo, especially when combined with immune checkpoint blockade.
CANCER GENE THERAPY
(2023)
Article
Cell Biology
Jennifer L. Uhrlaub, Mladen Jergovic, Christine M. Bradshaw, Sandip Sonar, Christopher P. Coplen, Jarrod Dudakov, Kristy O. Murray, Marion C. Lanteri, Michael P. Busch, Marcel R. M. van den Brink, Janko Nikolich-Zugich
Summary: Older humans and animals exhibit reduced immune responses to infection and vaccination, which is correlated to the numbers and frequency of naive T cells. Increasing the number of CD8 T cells can improve clinical outcomes of West Nile virus. However, IL-7C treatment does not improve immune defense against the virus in older animals.
Article
Immunology
Konjit Getachew Muleta, Isabel Ulmert, Kedir Hussen Hamza, Sharne van Dijl, Joy Nakawesi, Katharina Lahl
Summary: Rotavirus (RV) infection induces strong adaptive immunity, with initial clearance depending on cytotoxic CD8 T cells. Type I classical dendritic cells (cDC1) play a key role in CD8 T cell induction and RV cytotoxicity. This study found that the individual Toll-like receptor 3 (TLR3) and MyD88-mediated signaling pathways were not required for CD8 T cell response or RV clearance. Surprisingly, absence of type I interferon (IFN) signaling did not alter the accumulation of RV-specific CD8 T cells, but it impaired their ability to produce IFN gamma and granzyme.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Tao Peng, Khamsone Phasouk, Emily Bossard, Alexis Klock, Lei Jin, Kerry J. Laing, Christine Johnston, Noel A. Williams, Julie L. Czartoski, Dana Varon, Annalyssa N. Long, Jason H. Bielas, Thomas M. Snyder, Harlan Robins, David M. Koelle, M. Juliana McElrath, Anna Wald, Lawrence Corey, Jia Zhu
Summary: Our study identified distinct populations of CD8(+) TRMs in the human ectocervix with different expression patterns, anatomical locations, and TCR repertoires, which target relevant viral antigens for improved host defense against sexually transmitted infections.
Article
Gastroenterology & Hepatology
Greta Acerbi, Ilaria Montali, Gennaro Domenico Ferrigno, Valeria Barili, Simona Schivazappa, Arianna Alfieri, Diletta Laccabue, Alessandro Loglio, Marta Borghi, Marco Massari, Marzia Rossi, Andrea Vecchi, Amalia Penna, Carolina Boni, Gabriele Missale, Pietro Lampertico, Daniele Del Rio, Carlo Ferrari, Paola Fisicaro
Summary: In chronic HBV infection, virus-specific CD8 T cells show impaired autophagic flux, while bioactive compounds such as resveratrol and oleuropein can improve mitochondrial and proteostasis functions in T cells. The combination of polyphenols with antioxidants represents a promising strategy for immune reconstitution in chronic HBV infection.
JOURNAL OF HEPATOLOGY
(2021)
Article
Immunology
Zhiqiang Zhu, Yuanyuan Qin, Qi Liang, Wei Xia, Tong Zhang, Wen Wang, Mengmeng Zhang, Taiyi Jiang, Hao Wu, Ye Tian
Summary: The coinfection rate of HBV in HIV patients increases as HIV disease progresses, possibly due to the reduced numbers of HBV-specific IFN-gamma-producing CD8+ T cells. Close monitoring of HBV serum markers from the early stage of HIV infection is necessary.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ilenia Pacella, Ilenia Cammarata, Carmela Martire, Giuseppina Brancaccio, Giovanni Battista Gaeta, Vincenzo Barnaba, Silvia Piconese
Summary: The study revealed that in patients with chronic HBV infection receiving NUC therapy and having advanced hepatic fibrosis, the frequency of AE-specific CD8(+) T cells was significantly increased. Different specificities of CD8(+) T cells were found to populate distinct subpopulations, suggesting a link between AE-specific T cells and advanced liver fibrosis.
LIVER INTERNATIONAL
(2021)
Article
Immunology
Alba Grifoni, Hannah Voic, Esther Dawen Yu, Jose Mateus, Kai Mei Yan Fung, Alice Wang, Gregory Seumois, Aruna D. De Silva, Rashika Tennekon, Sunil Premawansa, Gayani Premawansa, Rashmi Tippalagama, Ananda Wijewickrama, Ashu Chawla, Jason Greenbaum, Bjoern Peters, Vijayanand Pandurangan, Daniela Weiskopf, Alessandro Sette
Summary: This study investigated the transcriptomic profiles of DENV-specific CD8+ T cells in hospitalized dengue patients and found multiple gene signatures associated with these cells. The study also showed that there were no differences in quantity and quality of DENV-specific CD8+ T cells based on disease severity. These findings suggest that altered DENV-specific T cell responses are not a correlate of immunopathology.
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederick J. Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects motor neurons and muscle control, with different gene mutations defining subtypes. A specific immune signature has been identified in ALS4 patients, potentially serving as a biomarker for disease progression.
Article
Chemistry, Multidisciplinary
Chao Yang, Lin-Xiao Hou, Bei-Dou Xi, Li-An Hou, Xiao-Song He
Summary: This study investigated the redox capacities of compost-derived humic substances (HS) and their impact on the hematite bioreduction. The results showed that compost-derived HS could promote the bioreduction of hematite and their redox capacities increased during composting. The aromatic functional groups and heteroatom structures, particularly nitrogen, were found to be important for the hematite bioreduction.
CHINESE CHEMICAL LETTERS
(2022)
Article
Agricultural Engineering
Chengze Yu, Mingxiao Li, Bin Zhang, Yanjun Xin, Wenbing Tan, Fanhua Meng, Jiaqi Hou, Xiaosong He
Summary: The study found that hydrothermal pretreatment in HTPAF can effectively degrade lignin and form a loose pore structure on the surface of chestnut shells, which is conducive to rapid compost maturation. Optimized process parameters can shorten the fermentation time of compost and present different characteristics in microbial communities compared to traditional composting.
BIORESOURCE TECHNOLOGY
(2022)
Letter
Engineering, Environmental
Ying Zhang, Yawen Peng, Chu Peng, Ping Wang, Yuan Lu, Xiaosong He, Lei Wang
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Virology
Ciara T. Hu, Karina Diaz, Linda C. Yang, Anjali Sharma, Harry B. Greenberg, Jason G. Smith
Summary: This study highlights the potential role of enteric alpha-defensins in the evolution and tropism of rotaviruses, with species-specific activities observed. The VP4 protein of rotavirus is identified as a determinant of alpha-defensin sensitivity. These findings provide insights into the mechanism of defensin neutralization and emphasize the importance of studying a broader range of rotaviruses with different VP4 genotypes.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Gerson I. Caraballo, Romel Rosales, Mercedes Viettri, Juan Manuel Castillo, Raymundo Cruz, Siyuan Ding, Harry B. Greenberg, Juan E. Ludert
Summary: Dengue is the most important mosquito-borne viral disease to humans. Dengue virus NS1 is a multifunctional protein essential for replication and modulation of innate immunity. The protein interactome of DENV NS1 in mosquito cells was investigated, revealing interactions with various mosquito protein targets. This study provides novel insights into the functions of NS1 and its role in promoting viral replication, as well as identifying new protein pathways involved in mosquito cells.
JOURNAL OF VIROLOGY
(2022)
Article
Chemistry, Physical
Minda Yu, Xuhui Mao, Xiaosong He, Mingxia Zheng, Xu Zhang, Jing Su, Beidou Xi
Summary: This study demonstrates the enhancement of peroxide activation efficiency and organic contaminant degradation by mechanically silicified microscale zero-valent iron (mZVI). The silicification process improves the generation of reactive intermediates, resulting in a significant increase in sulfamethazine removal rate. Continuous generation of ferrous ions in the Si-mZVI(bm)/PDS system after silicification contributes to the excellent performance of peroxide activation.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Immunology
Bin Liu, Guo-Xiang Yang, Ying Sun, Takashi Tomiyama, Weici Zhang, Patrick S. C. Leung, Xiao-Song He, Sandeep Dhaliwal, Pietro Invernizzi, M. Eric Gershwin, Christopher L. Bowlus
Summary: This study found that the frequency of circulating NK cells in patients with PSC was lower and their phenotype was less mature, with enhanced cytotoxic activity. These changes may be involved in the pathogenesis and progression of PSC, suggesting the potential of NK-directed immunotherapy for treating PSC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Runzi Cao, Xinna Liu, Jiajun Duan, Bowen Gao, Xiaosong He, Nanthi Bolan, Yang Li
Summary: Dissolved organic matter (DOM) has different effects on the photoaging process of nano- and micro-plastic particles. DOM promotes the aging of aliphatic plastic particles, while inhibiting or only slightly affecting the aging of aromatic plastic particles. This study reveals the photoaging mechanisms of plastic particles with different compositions and structures in water.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Jiajun Ou, Junlin Wen, Wenbing Tan, Xiaoshan Luo, Jiexuan Cai, Xiaosong He, Lihua Zhou, Yong Yuan
Summary: Linear and nonlinear models were used to monitor the structure dependence of humic substances (HS) redox activities. The PLS model showed moderate ability, while the ANN model achieved higher performance. Sensitivity analysis confirmed the accuracy of the models and provided a potential approach for studying the structure-activity relationships of HS.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Chenghao Huang, Nannan Yuan, Xiaosong He, Changhui Wang
Summary: The use of ceramsite as a filtration material in water treatment is popular, and the development of low-cost, high-performance, and environmentally friendly ceramsites has gained attention. This study focuses on exploring the use of drinking water treatment residue (DWTR) to make ceramsite for water treatment. The results show that DWTR-based ceramsites can be fabricated using sintering and non-sintering methods. Further research is needed to evaluate the performance and potential for pollution control of DWTR-based ceramsite-constructed filtration systems, as well as the stability and safety of raw DWTR-based ceramsite.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Environmental Sciences
Xiaowei Wang, Hongwei Zhang, Xiaosong He, Jianfei Liu, Zhiliang Yao, Hongbin Zhao, Dayang Yu, Baosen Liu, Tianfu Liu, Weilong Zhao
Summary: Limited information on contamination of PFASs from agricultural activities in water sources. Investigated PFASs contamination in agricultural groundwater and nearby surface water in North China. Found higher PFAS concentrations in surface water, indicating migration from surface to groundwater. Found significant correlations between PFASs and organic carbon/nutrients in water. Health risk assessment showed no significant harm to residents in the studied area. Provided information on sources and migration characteristics of PFASs in a typical agricultural area of North China.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Review
Environmental Sciences
Qi Pan, Qing-Yu Liu, Jing Zheng, Yan-Hong Li, Song Xiang, Xiao-Jie Sun, Xiao-Song He
Summary: Gas emitted from landfills contains a large quantity of volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs), some of which are carcinogenic, teratogenic, and mutagenic. The global hazards of VOCs and SVOCs in landfill gas to human health remain unclear. To quantify the global risk distributions of these pollutants, the composition and concentration data of VOCs and SVOCs from 72 landfills in 20 countries were collected and their human health risks were assessed. Organic compounds in landfill gas primarily result from the biodegradation of natural organic waste or the emissions and volatilization of chemical products. The respiratory system, particularly the lung, was found to be the major target organ of VOCs and SVOCs, with additional adverse health impacts ranging from headache and allergies to lung cancer. Aromatic and halogenated compounds were the primary sources of health risk, while ethyl acetate and acetone from the biodegradation of natural organic waste also exceeded the acceptable levels for human health. Overall, VOCs and SVOCs affected residents within 1,000 m of landfills. Air temperature, relative humidity, air pressure, wind direction, and wind speed were the major factors that influenced the health risks of VOCs and SVOCs. Currently, landfill risk assessments of VOCs and SVOCs are primarily based on respiratory inhalation, with health risks due to other exposure routes remaining poorly elucidated. In addition, potential health risks due to the transport and transformation of landfill gas emitted into the atmosphere should be further studied.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Takahiro Kawagishi, Liliana Sanchez-Tacuba, Ningguo Feng, Veronica P. Costantini, Ming Tan, Xi Jiang, Kim Y. Green, Jan Vinje, Siyuan Ding, Harry B. Greenberg
Summary: Rotaviruses (RVs) primarily replicate in the small intestine and cause severe diarrheal disease. Rhesus rotavirus (RRV) can be used as a vaccine and has been extensively studied in mice. Recombinant RVs expressing foreign proteins have not been tested as vaccine vectors yet. This study showed that recombinant RRVs expressing human norovirus proteins can induce an immune response in mice, suggesting the potential of using RV as a vaccine vector against gastrointestinal pathogens.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Virology
Ciara T. Hu, Karina Diaz, Linda C. Yang, Anjali Sharma, Harry B. Greenberg, Jason G. Smith
Summary: The study investigates the role of alpha-defensins in the replication and transmission of fecal-oral pathogens. The activity of alpha-defensins varies between species and can affect microbial evolution, tissue tropism, species tropism, and zoonotic potential. The research highlights the resistance and sensitivity of rotaviruses to host enteric alpha-defensins and identifies the viral protein VP4 as a determinant of alpha-defensin sensitivity.
JOURNAL OF VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Panagiotis Fotiadis, Matthew Cieslak, Xiaosong He, Lorenzo Caciagli, Mathieu Ouellet, Theodore D. Satterthwaite, Russell T. Shinohara, Dani S. Bassett
Summary: Recent work has found that the relationship between structural and functional connectivity in the human brain varies across different regions, with reduced connectivity observed in the sensory-association cortical hierarchy. This study suggests that intracortical myelination and excitation-inhibition balance play a role in mediating the heterogeneous expression and temporal variance of structure-function coupling.
NATURE COMMUNICATIONS
(2023)