Article
Virology
A. Yigitliler, J. Renner, C. Simon, M. Schneider, F. Stubenrauch, T. Iftner
Summary: The E2 protein encoded by human papillomaviruses interacts with the BRD4 and BRD4S proteins to control viral processes. BRD4S negatively regulates E2 activities and inhibits HPV transcription, leading to immune evasion and establishment of persistent HPV infections.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyuan He, Jung-Sik Kim, Laura A. Diaz-Martinez, Cecil Han, William S. Lane, Bogdan Budnik, Todd Waldman
Summary: The study identified USP13 as a novel cohesin-interacting protein that regulates the ubiquitination of cohesin and its interaction with chromatin during the cell cycle.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Xiaoqing Nie, Qianhua Xu, Chengpeng Xu, Fengling Chen, Qizhi Wang, Dandan Qin, Rui Wang, Zheng Gao, Xukun Lu, Xinai Yang, Yu Wu, Chen Gu, Wei Xie, Lei Li
Summary: This study reveals that TDP-43, a maternal factor, is crucial for mouse embryonic development by regulating RNA Pol II and mediating zygotic genome activation. The authors demonstrate that TDP-43 forms large foci with RNA Pol II in the nucleus and co-occupies the promoters of zygotic genome activation genes. Depletion of maternal TDP-43 leads to defective zygotic genome activation and arrested development at the two-cell stage.
NATURE COMMUNICATIONS
(2023)
Article
Virology
Leny Jose, Elliot J. Androphy, Marsha DeSmet
Summary: This study demonstrates that methylation of Brd4 by SETD6 in HPV-episomal cells is necessary for the activation of viral transcription. It reveals a novel regulatory mechanism involving E2, Brd4, and SETD6 in the HPV life cycle, shedding light on the multiple roles of Brd4 in viral pathogenesis.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Duygu Gezen-Ak, Merve Alaylioglu, Zuhal Yurttas, Tugay Camoglu, Busra Sengul, Cihan Islerc, Umit Yasar Kina, Ebru Keskin, Irem Lutfiye Atasoy, Ali Metin Kafardar, Mustafa Uzan, Cedric Annweiler, Erdinc Dursun
Summary: In this study, it was found that Vitamin D receptor (VDR) may function as a mitochondrial transcription factor and regulate the transcription of mitochondrial DNA (mtDNA). The research also revealed the interaction between VDR and mitochondrial transcription factor A (TFAM), suggesting their joint involvement in the regulation of mitochondrial function. These findings not only uncover a novel role of VDR, but also highlight its indispensability for energy-demanding cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Plant Sciences
Chien-Chang Wang, Hsin-Yu Hsieh, Hsu-Liang Hsieh, Shih-Long Tu
Summary: The study demonstrates that H3K36me3 rapidly and differentially responds to light at specific gene loci, leading to light-regulated intron retention in transcripts. The chromatin adaptor PpMRG1 potentially participates in light-mediated alternative splicing in plants.
Article
Multidisciplinary Sciences
Cuige Zhu, Mari Iwase, Ziqian Li, Faliang Wang, Annabel Quinet, Alessandro Vindigni, Jieya Shao
Summary: This study reveals the previously unknown nuclear functions of the actin-binding factor profilin-1 (PFN1) in DNA replication. PFN1 interacts with poly-L-proline (PLP)-containing proteins to regulate DNA replication initiation, fork progression, and fork stalling under replication stress. Moreover, PFN1 collaborates with fork reversal enzymes to promote over-resection of unprotected forks. These findings suggest that PFN1 is a multi-functional regulator of DNA replication and could be potentially targeted for anti-cancer therapy.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Frank Stubenrauch, Elke Straub, Katrin Klein, Daniela Kramer, Thomas Iftner, Margaret Wong, Richard B. S. Roden
Summary: The HPV-encoded E8<^>E2 protein acts as repressors of viral gene expression and genome replication and is necessary for tumor formation in vivo. This indicates that E8<^>E2 could be a potential target for antiviral therapy in vivo.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Apurva T. Prabhakar, Claire D. James, Dipon Das, Raymonde Otoa, Matthew Day, John Burgner, Christian T. Fontan, Xu Wang, Sarah H. Glass, Andreas Wieland, Mary M. Donaldson, Molly L. Bristol, Renfeng Li, Anthony W. Oliver, Laurence H. Pearl, Brian O. Smith, Iain M. Morgan
Summary: The CK2 phosphorylation of the E2 protein at serine 23 promotes its interaction with TopBP1, playing a critical role in the viral life cycle.
Article
Biochemistry & Molecular Biology
Yanxia Wu, Yanxi Sun, Binchu Xu, Mo Yang, Xingwu Wang, Xiaocheng Zhao
Summary: The lncRNA SCARNA10 interacts with the DNA binding domain (DBD) of the tumor suppressor p53, promoting its acetylation modification and activating p53-mediated transcriptional activity. This involvement of SCARNA10 in various cellular processes such as cell cycle arrest, apoptosis, DNA repair, cell metabolism, and ferroptosis highlights its importance in tumor suppression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Virology
Apurva T. Prabhakar, Claire D. James, Christian T. Fontan, Raymonde Otoa, Xu Wang, Molly L. Bristol, Ronald D. Hill, Aanchal Dubey, Iain M. Morgan
Summary: Human papillomaviruses (HPV) are pathogens that cause a range of diseases. Understanding the HPV life cycle is crucial for developing novel treatments, as there are currently no therapeutics directly targeting viral proteins or processes. This study demonstrates the importance of the E2-TopBP1 interaction in maintaining E2 and viral genome stability during the HPV life cycle. Disruption of this interaction can promote viral genome integration.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amel Ben Saad, Virginie Vauthier, Martine Lapalus, Elodie Mareux, Evangeline Bennana, Anne-Marie Durand-Schneider, Alix Bruneau, Jean-Louis Delaunay, Emmanuel Gonzales, Chantal Housset, Tounsia Ait-Slimane, Francois Guillonneau, Emmanuel Jacquemin, Thomas Falguieres
Summary: ABCB4 is an ABC transporter crucial for phosphatidylcholine secretion into bile. Research has identified RAB10 as a novel molecular partner of ABCB4, influencing its plasma membrane expression and function. Understanding the interactions between RAB10 and ABCB4 may lead to the development of novel therapies for liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Rui Lin, Jianing Song, Mingjia Tang, Lingyu Wang, Jingquan Yu, Yanhong Zhou
Summary: This study reveals that CaM6 negatively regulates plant cold tolerance by attenuating ICE1 and decreasing the expression levels of ICE1-dependent stress- and metabolism-related genes. The findings shed light on the mechanism of plant response to cold stress and provide insight into the role of CaM6 in the regulation of ICE1.
Article
Agronomy
Meiqing Xing, Wei Wang, Xing Fang, Hongwei Xue
Summary: Leaf inclination, an important component of crop architecture, is regulated by the phytohormones auxin and brassinosteroids. This study reveals the genetic control of leaf inclination and the synergistic effects of auxin and brassinosteroids in rice.
Article
Plant Sciences
Shuangrong Liu, Liwen Yang, Jialong Li, Weijiang Tang, Jigang Li, Rongcheng Lin
Summary: The study reveals that the red/far-red-absorbing photoreceptor phyB and the transcription factor FHY3 cooperatively regulate seed dormancy and germination in Arabidopsis thaliana. FHY3 affects seed growth and development by regulating multiple downstream genes. Additionally, light and phyB can promote the accumulation of FHY3 protein.
Article
Virology
Sara P. Culleton, Sriramana Kanginakudru, Marsha DeSmet, Timra Gilson, Fang Xie, Shwu-Yuan Wu, Cheng-Ming Chiang, Guihong Qi, Mu Wang, Elliot J. Androphy
JOURNAL OF VIROLOGY
(2017)
Article
Virology
Yanique Thomas, Elliot J. Androphy
JOURNAL OF VIROLOGY
(2018)
Article
Multidisciplinary Sciences
Mani Shankar Babu, Sailendra Mahanta, Alexander J. Lakhter, Takashi Hato, Subhankar Paul, Samisubbu R. Naidu
Article
Virology
Yanique Thomas, Elliot J. Androphy
JOURNAL OF VIROLOGY
(2019)
Article
Virology
Marsha DeSmet, Leny Jose, Nasro Isaq, Elliot J. Androphy
JOURNAL OF VIROLOGY
(2019)
Article
Pharmacology & Pharmacy
Jonathan Oliva, Scott Galasinski, Amelia Richey, Amy E. Campbell, Marvin J. Meyers, Neal Modi, Jun Wen Zhong, Rabi Tawil, Stephen J. Tapscott, Francis M. Sverdrup
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2019)
Article
Virology
Leny Jose, Elliot J. Androphy, Marsha DeSmet
JOURNAL OF VIROLOGY
(2020)
Article
Virology
Timra Gilson, Sara Culleton, Fang Xie, Marsha DeSmet, Elliot J. Androphy
JOURNAL OF VIROLOGY
(2020)
Article
Virology
Leny Jose, Marsha DeSmet, Elliot J. Androphy
JOURNAL OF VIROLOGY
(2020)
Article
Microbiology
Ryan T. Gibson, Elliot J. Androphy
Article
Biology
Anne Rietz, Kevin J. Hodgetts, Hrvoje Lusic, Kevin M. Quist, Erkan Y. Osman, Christian L. Lorson, Elliot J. Androphy
Summary: Researchers established a tunable model of mild and moderate SMA using a splicing compound, demonstrating prevention of severe SMA phenotype and phenotypic recovery when administered on day eight.
LIFE SCIENCE ALLIANCE
(2021)
Review
Microbiology
Leny Jose, Timra Gilson, Elliot J. Androphy, Marsha DeSmet
Summary: HPV is a DNA tumor virus that causes various cancers, with the E2 protein being essential for viral replication and regulated by various modifications. Recent advancements have identified post translational modifications within E2 that control viral replication.
Article
Oncology
Samisubbu R. Naidu, Maegan Capitano, James Ropa, Scott Cooper, Xinxin Huang, Hal E. Broxmeyer
Summary: Research has shown that the absence of Brm in mice results in increased numbers of HSCs and HPCs in the bone marrow, but decreased engraftment in secondary and tertiary transplants, indicating that BRM enhances HSC self-renewal. Valine, through regulating BRM expression in HPCs, influences the proliferation and differentiation of HSCs and HPCs.
Article
Virology
Leny Jose, Elliot J. Androphy, Marsha DeSmet
Summary: This study demonstrates that methylation of Brd4 by SETD6 in HPV-episomal cells is necessary for the activation of viral transcription. It reveals a novel regulatory mechanism involving E2, Brd4, and SETD6 in the HPV life cycle, shedding light on the multiple roles of Brd4 in viral pathogenesis.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Sriramana Kanginakudru, Timra Gilson, Leny Jose, Elliot J. Androphy
Summary: Epidemiological studies have shown that caffeinated coffee can reduce the risk of oropharyngeal cancer caused by HPV. Caffeine inhibits the DNA damage response pathway, which affects the replication of HPV. Caffeine reduces the HPV copy number in the early stage of infection but increases the copy number of HPV episomes in later stages.