期刊
JOURNAL OF VIROLOGY
卷 82, 期 18, 页码 9288-9292出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00704-08
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资金
- DFG [SPP 1175, SFB 740]
- ISTC [2816P]
- RFBR [06-04-48728]
S acylation of cysteines located in the transmembrane and/or cytoplasmic region of influenza virus hemagglutinins (HA) contributes to the membrane fusion and assembly of virions. Our results from using mass spectrometry (MS) show that influenza B virus HA possessing two cytoplasmic cysteines contains palmitate, whereas HA-esterase-fusion glycoprotein of influenza C virus having one transmembrane cysteine is stearoylated. HAs of influenza A virus having one transmembrane and two cytoplasmic cysteines contain both palmitate and stearate. MS analysis of recombinant viruses with deletions of individual cysteines, as well as tandem-MS sequencing, revealed the surprising result that stearate is exclusively attached to the cysteine positioned in the transmembrane region of HA.
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