Article
Biochemistry & Molecular Biology
Ji-Min Park, Hyunyoung Yoon, Yuna Jeong, Kyung Lib Jang
Summary: P53 inhibits HCV replication by downregulating HCV Core protein levels through enhancing E6AP-mediated ubiquitination and degradation of HCV Core.
Article
Biochemistry & Molecular Biology
Xu Li, Shu Zhuo, Yong Suk Cho, Yuchen Liu, Yingzi Yang, Jian Zhu, Jin Jiang
Summary: Hippo signaling inhibits the oncogenic potential of YAP/TAZ-TEAD transcriptional complex, restricting tumor growth. In AR-positive prostate cancer, YAP acts as a tumor suppressor by counteracting TEAD-mediated AR signaling. YAP competes with AR for TEAD binding, disrupting AR-TEAD interaction and preventing TEAD from promoting AR signaling. Targeting the Hippo signaling pathway may provide a therapeutic opportunity to treat therapy resistant AR variants-driven prostate cancer.
Review
Microbiology
Darshika J. Udawatte, Alan L. Rothman
Summary: RIPK1 serves as a key regulator of cell death and inflammation, affecting the outcome of virus infections through activation of different signaling pathways. Viruses manipulate host immune responses by targeting RIPK1, highlighting potential directions for future research.
Review
Microbiology
Anshuman Das, Efrain E. Rivera-Serrano, Xin Yin, Christopher M. Walker, Zongdi Feng, Stanley M. Lemon
Summary: In this Review, the authors discuss quasi-enveloped virions, their entry and release from human host cells, and their impact on host immunity and pathogenesis. They focus on hepatitis A and E viruses, which were previously considered non-enveloped but are now known to be released as quasi-enveloped virions cloaked in host membranes. Despite lacking virally encoded proteins on their surface, these virions efficiently enter cells and replicate. The authors also describe the mechanisms by which specific peptide sequences in the capsids of these virions mediate their release from hepatocytes and the current understanding of their cell entry mechanism.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Oncology
Gang Yuan, Bin Chen, Yina Meng, Jialin Lu, Xiaojun Shi, Airong Hu, Yaoren Hu, Donghui Wang
Summary: Interfering with CXCR3 inhibits cell proliferation and migration, promotes cell apoptosis, and suppresses the expression levels of proteins in the TLRs/MyD88 pathway. This ultimately prevents the progression from chronic hepatitis B to liver cancer.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Virology
Savvina Moustafa, Katerina Kassela, Maria Bampali, Nikolas Dovrolis, Athanassios Kakkanas, Apostolos Beloukas, Penelope Mavromara, Ioannis Karakasiliotis
Summary: This study analyzed the role of HCV core protein in TNF alpha-induced death, considering the genetic variability of HCV. The results showed that only HCV 4a core protein increased sensitivity to TNF alpha-induced death. Transgenic mice expressing HCV 4a core protein were more susceptible to the LPS/Dgal model, while mice expressing HCV 4f core protein had the same susceptibility as controls.
Review
Biochemistry & Molecular Biology
Sunil Kumar Sukumaran, Salin Raj Palayyan
Summary: Sweet taste is a crucial factor in food intake, but excessive consumption of sugar-derived calories can lead to obesity and other metabolic diseases. Understanding the mechanisms of sweet taste signaling is essential for developing better noncaloric sweeteners. Sweet taste receptor cells have multiple signaling pathways, but the regulation of sweet taste signaling is not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Neetu Saxena, Eliana Beraldi, Ladan Fazli, Syam Prakash Somasekharan, Hans Adomat, Fan Zhang, Chidi Molokwu, Anna Gleave, Lucia Nappi, Kimberly Nguyen, Pavn Brar, Nicholas Nikesitch, Yuzhuo Wang, Colin Collins, Poul H. Sorensen, Martin Gleave
Summary: This study reveals that after AR pathway inhibition, acute adaptive responses support the reactivation of AR and the development of PCa by regulating SDH activity and Hsp27 protein. Co-targeting AR and Hsp27 can enhance the sensitivity of PCa cells to ARPI treatments.
EMBO MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mu Lv, Juanjuan Yu, Yan Huang, Jie Ma, Jun Xiang, Yanqiu Wang, Linxia Li, Zhenbo Zhang, Hong Liao
Summary: Uterine diseases, such as endometriosis and uterine fibroids, have a significant impact on women's health. Androgens, primarily synthesized in the ovaries and adrenal glands, play a crucial role in the development of these diseases. However, further research is needed to understand the signaling pathways involved and develop targeted therapeutic strategies.
Review
Biochemistry & Molecular Biology
Caroline Lefeuvre, Helene Le Guillou-Guillemette, Alexandra Ducancelle
Summary: Chronic HBV infection is a common factor associated with HCC, with studies showing that the HBc protein plays a significant role in affecting pathways involved in HCC development, such as migration, proliferation, apoptosis, metabolism, and immune responses. HBc can also promote HCC metastasis by modulating host gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biophysics
Suchanat Boonkaew, Abdulhadee Yakoh, Nattaya Chuaypen, Pisit Tangkijvanich, Sirirat Rengpipat, Weena Siangproh, Orawon Chailapakul
Summary: Electrochemical paper-based analytical devices (ePADs) are simple, portable, and low-cost analytical devices for point-of-care testing of clinical biomarkers. A sequential ePAD has been developed for simultaneous detection of hepatitis B surface antigen and hepatitis C core antigen by integrating dual flow behaviors, avoiding the need for complex multi-step reagent manipulation by the user. The proposed ePAD shows high promise as an easy-to-use, portable, and extendable sensor for other multiplex biological assays.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biotechnology & Applied Microbiology
Sujeong Lee, Hyunyoung Yoon, Jiwoo Han, Kyung Lib Jang
Summary: Most studies have shown that HCV dominates over HBV in coinfection, with the HCV core protein inhibiting HBV replication by downregulating HBx levels. This is achieved through an increase in reactive oxygen species levels and activation of specific pathways, leading to the degradation of HBx.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Microbiology
Harini Sooryanarain, S. Ansar Ahmed, Xiang-Jin Meng
Summary: The study found that progesterone significantly increases HEV replication in human liver cells, but does not modulate HEV-induced interferon response. PGRMC1/2 receptors affect the levels of HEV-induced IFN-lambda 1 expression via the ERK pathway, resulting in reduced HEV replication.
Article
Multidisciplinary Sciences
Hyunyoung Yoon, Kyung Lib Jang
Summary: This study found that HBV X protein and HCV core protein work together to inhibit the expression of E-cadherin in cells, leading to an increased risk of hepatocellular carcinoma. HBV and HCV increase the level and activity of DNA methyl-transferases, resulting in hypermethylation of the E-cadherin promoter. This leads to epithelial-mesenchymal transition and tumor metastasis.
Article
Virology
Takayuki Abe, Yuki Marutani, Lin Deng, Chieko Matsui, Masayoshi Fukasawa, Ryosuke Suzuki, Takaji Wakita, Yoshiharu Matsuura, Ikuo Shoji
Summary: Host cells have defense mechanisms to restrict viral infection, but viruses have counteracting strategies to infect. This study found that ANX5 and PKC isoforms, including PKC alpha and PKC eta, play a role in suppressing HCV infection by regulating OCLN integrity. Disruption of OCLN integrity increases HCV infection, and HCV disrupts ANX5-mediated OCLN integrity by downregulating PKC alpha and PKC eta expression to promote viral infection.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Terunao Iwanaga, Tetsuhiro Chiba, Masato Nakamura, Tatsuya Kaneko, Junjie Ao, Na Qiang, Yaojia Ma, Jiaqi Zhang, Tadayoshi Kogure, Sae Yumita, Takamasa Ishino, Keita Ogawa, Motoyasu Kan, Miyuki Nakagawa, Kisako Fujiwara, Naoto Fujita, Takafumi Sakuma, Hiroaki Kanzaki, Keisuke Koroki, Yuko Kusakabe, Masanori Inoue, Kazufumi Kobayashi, Naoya Kanogawa, Soichiro Kiyono, Takayuki Kondo, Ryo Nakagawa, Sadahisa Ogasawara, Shingo Nakamoto, Ryosuke Muroyama, Jun Kato, Tatsuo Kanda, Hitoshi Maruyama, Naoya Mimura, Takuya Honda, Toshihiko Murayama, Hiroyuki Nakamura, Naoya Kato
Summary: This study demonstrates that miglustat can suppress liver fibrosis by inhibiting the TGF-5/Smad pathway, reducing the expression of extracellular matrix components such as collagen. The research also shows that miglustat can both prevent the occurrence of liver fibrosis and reverse established fibrosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Keiichi Fujiwara, Shin Yasui, Takayuki Kondo, Masato Nakamura, Makoto Arai, Tatsuo Kanda, Osamu Yokosuka, Masayuki Ohtsuka, Ryuzo Abe, Naoya Kato
Summary: The prognosis of patients with fulminant hepatitis and late-onset hepatic failure in Japan has not improved over the past 32 years, despite advancements in clinical management and liver transplantation. The increasing proportion of patients with poor prognosis and difficult-to-treat etiologies, as well as the aging population, may contribute to this lack of improvement.
HEPATOLOGY RESEARCH
(2023)
Article
Virology
Reina Sasaki-Tanaka, Ryota Masuzaki, Hiroaki Okamoto, Toshikatsu Shibata, Mitsuhiko Moriyama, Hirofumi Kogure, Tatsuo Kanda
Summary: This study identified nicotinamide as a potential therapeutic drug for HAV infection by inhibiting HAV replication through suppressing AP-1 activity and HAV IRES-mediated translation.
JOURNAL OF VIROLOGY
(2023)
Article
Surgery
Hayato Abe, Kazu Shibutani, Shintaro Yamazaki, Tatsuo Kanda, Mitsuhiko Moriyama, Masahiro Okada, Masahiko Sugitani, Shingo Tsuji, Tadatoshi Takayama, Yukiyasu Okamura
Summary: This study aimed to investigate the predictive value of preoperative tumor stiffness measured by magnetic resonance elastography on overall survival and recurrence-free survival in patients with hepatocellular carcinoma. The results showed that higher tumor stiffness was associated with increased risk of recurrence and death.
Article
Oncology
Keita Ogawa, Tetsuhiro Chiba, Masato Nakamura, Jun Arai, Jiaqi Zhang, Yaojia Ma, Na Qiang, Junjie Ao, Sae Yumita, Takamasa Ishino, Motoyasu Kan, Terunao Iwanaga, Miyuki Nakagawa, Kisako Fujiwara, Takafumi Sakuma, Hiroaki Kanzaki, Keisuke Koroki, Yuko Kusakabe, Kazufumi Kobayashi, Naoya Kanogawa, Soichiro Kiyono, Takayuki Kondo, Ryo Nakagawa, Sadahisa Ogasawara, Ryosuke Muroyama, Shingo Nakamoto, Tatsuo Kanda, Hitoshi Maruyama, Jun Kato, Shoji Matsumoto, Takayoshi Arai, Shinichiro Motohashi, Naoya Kato
Summary: In this study, the inhibition of ADAM9 was found to prevent the release of MICA and activate the immune function of NK cells. Through the screening of a chemical library, a compound called CCL347 with five benzene rings was identified, which significantly reduced sMICA levels in HCC cell lines and enhanced NK cell cytotoxicity, indicating its potential as a novel therapeutic drug for HCC.
ANTICANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Reina Sasaki-Tanaka, Toshikatsu Shibata, Mitsuhiko Moriyama, Hirofumi Kogure, Asuka Hirai-Yuki, Hiroaki Okamoto, Tatsuo Kanda
Summary: In this study, HuhT7-HAV/Luc cells were established as a suitable model for anti-HAV drug screening. Masitinib, a tyrosine kinase inhibitor, was found to reduce HAV replication and internal ribosomal entry-site (IRES) activity. It may be a potential treatment for severe HAV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tatsuo Kanda, Ryota Masuzaki, Reina Sasaki-Tanaka, Hirofumi Kogure, Mitsuhiko Moriyama
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Tatsuo Kanda
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shini Kanezawa, Mitsuhiko Moriyama, Tatsuo Kanda, Akiko Fukushima, Ryota Masuzaki, Reina Sasaki-Tanaka, Akiko Tsunemi, Takahiro Ueno, Noboru Fukuda, Hirofumi Kogure
Summary: Metabolic-dysfunction-associated fatty-liver disease (MAFLD) is the leading cause of liver disease worldwide. Nonalcoholic steatohepatitis (NASH) patients have a higher prevalence of small-intestinal bacterial overgrowth (SIBO). In this study, we investigated the differences in gut microbiota between stroke-prone spontaneously hypertensive-5 rats (SHRSP5) fed a normal diet (ND) or a high-fat- and high-cholesterol-containing diet (HFCD). We found an association between MAFLD and gut microbiota alteration, suggesting that targeting gut microbiota may be a potential therapeutic approach for MAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Tatsuo Kanda, Reina Sasaki-Tanaka, Koji Ishii, Ryosuke Suzuki, Jun Inoue, Atsunori Tsuchiya, Shingo Nakamoto, Ryuzo Abe, Keiichi Fujiwara, Osamu Yokosuka, Tian-Cheng Li, Satoshi Kunita, Hiroshi Yotsuyanagi, Hiroaki Okamoto
Summary: The Japan Agency for Medical Research and Development (AMED) Hepatitis A and E viruses (HAV and HEV) Study Group has reviewed the recent advances in HAV research and clinical practice for HAV infection in Japan and authored comprehensive guidelines. The article covers virological findings, clinical presentation, pathogenicity, diagnostic approaches, complications, risk factors, preventive measures, and treatment modalities for hepatitis A.
HEPATOLOGY RESEARCH
(2023)
Article
Medicine, General & Internal
Tatsuo Kanda, Naoki Matsumoto, Tomotaka Ishii, Shuhei Arima, Shinji Shibuya, Masayuki Honda, Reina Sasaki-Tanaka, Ryota Masuzaki, Shini Kanezawa, Masahiro Ogawa, Shintaro Yamazaki, Osamu Aramaki, Hirofumi Kogure, Yukiyasu Okamura
Summary: Through living-donor liver transplantation (LDLT) from a HLA-matched sibling donor, the use of immunosuppressants can potentially be stopped. The prognosis of liver transplantation may be affected by acute and chronic rejection reactions mediated by anti-HLA antibodies and T cells, as well as the underlying liver disease of the recipient. This case report highlights the importance of initiating direct-acting antiviral (DAA) therapy immediately after LDLT for hepatitis C virus (HCV) infection, in order to improve the prognosis of the recipients.
Article
Medicine, Research & Experimental
Chikako Ikegami, Tatsuo Kanda, Tomotaka Ishii, Masayuki Honda, Yoichiro Yamana, Reina Sasaki Tanaka, Mariko Kumagawa, Shini Kanezawa, Taku Mizutani, Hiroaki Yamagami, Naoki Matsumoto, Ryota Masuzaki, Kentaro Hayashi, Kazushige Nirei, Tadateru Takayama, Mitsuhiko Moriyama
Summary: This case report describes a patient who developed recurrent COVID-19 pneumonia immediately after receiving combination treatment with DAAs for HCV infection. The patient was diagnosed with COVID-19 pneumonia 12 days after the end of treatment and experienced a second episode of recurrent COVID-19 pneumonia after discharge. However, the patient recovered from severe COVID-19 and achieved sustained virological response, with improvement in liver function.
Article
Oncology
Keita Ogawa, Hiroaki Kanzaki, Tetsuhiro Chiba, Junjie Ao, Na Qiang, Yaojia Ma, Jiaqi Zhang, Sae Yumita, Takamasa Ishino, Hidemi Unozawa, Motoyasu Kan, Terunao Iwanaga, Miyuki Nakagawa, Kisako Fujiwara, Naoto Fujita, Takafumi Sakuma, Keisuke Koroki, Yuko Kusakabe, Kazufumi Kobayashi, Naoya Kanogawa, Soichiro Kiyono, Masato Nakamura, Takayuki Kondo, Tomoko Saito, Ryo Nakagawa, Sadahisa Ogasawara, Eiichiro Suzuki, Shingo Nakamoto, Ryosuke Muroyama, Tatsuo Kanda, Hitoshi Maruyama, Naoya Mimura, Jun Kato, Shinichiro Motohashi, Naoya Kato
Summary: The treatment effect of ATZ/BV in patients with HCC with CTNNB1 mutation is comparable to those without CTNNB1 mutation.
Article
Medicine, General & Internal
Tomotaka Ishii, Keijiro Hoshino, Masayuki Honda, Yoichiro Yamana, Reina Sasaki-Tanaka, Mariko Kumagawa, Shini Kanezawa, Taku Mizutani, Naoki Matsumoto, Ryota Masuzaki, Kazushige Nirei, Hiroaki Yamagami, Mitsuhiko Moriyama, Tatsuo Kanda
Summary: This article describes a case of liver injury induced by benzbromarone in a male patient, emphasizing the importance of regular monitoring of liver function tests in patients taking benzbromarone.
Article
Medicine, General & Internal
Taku Mizutani, Kazushige Nirei, Tatsuo Kanda, Masayuki Honda, Tomotaka Ishii, Shuhei Arima, Yoichiro Yamana, Naoki Matsumoto, Shunichi Matsuoka, Mitsuhiko Moriyama
Summary: This study found that LGV width is a major risk factor for the deterioration of esophageal varices following BRTO in cirrhotic patients with gastric varices. More than half of the patients had LGV as the main inflow tract, and they experienced more frequent exacerbations of esophageal varices following BRTO compared to patients with different inflow tract sources.
MEDICINA-LITHUANIA
(2022)
