期刊
JOURNAL OF VIROLOGY
卷 82, 期 12, 页码 6034-6038出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00100-08
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NHLBI NIH HHS [R01 HL080388, HL-51670, P01 HL051670, R01 HL-61460] Funding Source: Medline
- NIDDK NIH HHS [P30 DK-54759, P30 DK054759] Funding Source: Medline
- NIGMS NIH HHS [2 T32 GM008629, T32 GM008629] Funding Source: Medline
Transmission of arenaviruses from rodent hosts to humans is generally thought to occur through inhalation or ingestion of dust or droplets containing viral particles. Here we demonstrate that two identified arenavirus receptors, alpha-dystroglycan (alpha-DG) and transferrin receptor 1 (TfR1), are expressed in polarized human airway epithelia. Lymphocytic choriomeningitis virus strains with high or low a-DG affinity and Junin virus, which binds TfR1, efficiently infected polarized epithelia only when applied to the basolateral surface or when injury compromised tight junction integrity. Viral egress from infected epithelia exhibited basolateral polarity. This study demonstrates that respiratory entry of arenaviruses occurs via basolateral receptors.
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