Article
Pharmacology & Pharmacy
Chunkyu Ko, Jinpeng Su, Julia Festag, Romina Bester, Anna D. Kosinska, Ulrike Protzer
Summary: The study demonstrated the formation of authentic cccDNA in mouse livers after delivery of HBV genomes by rAAV, independent of HBV replication. Intramolecular recombination of the overlength HBV genome was found to be the origin of cccDNA formation in mouse models, with a constant loss of cccDNA molecules over time.
ANTIVIRAL RESEARCH
(2021)
Article
Immunology
Eveline Hofmann, Bernard Surial, Noemie Boillat-Blanco, Huldrych F. Guenthard, Marcel Stoeckle, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, Franziska Suter-Riniker, Andri Rauch, Gilles Wandeler, Charles Beguelin
Summary: In the Swiss HIV Cohort Study, researchers found that 27% of HIV-suppressed individuals with chronic hepatitis B virus (HBV) infection had HBV replication after two years on tenofovir. However, 77% of them were able to achieve suppression thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were identified as predictors of persistent replication.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Virology
Hao Liao, He Zhang, Jinman Shao, Xiaoyong Li, Wei V. Zheng, Le Li, Guangxin Yu, Lanlan Si, Tao Zhou, Zengtao Yao, Jiuzeng Dai, Dongping Xu, Guanxun Cheng, Jiuxin Qu, Yan Liu, Junhui Chen, Fengmin Lu
Summary: This study aimed to investigate the dynamic changes of serum hepatitis B virus (HBV) RNA levels and the quasispecies of HBV RNA virus-like particles in nucleos(t)ide analogues (NAs)-experienced chronic hepatitis B patients with NAs-resistant mutations and their effects on NAs resistance. The results showed that serum HBV RNA can reflect virological breakthrough and rebound earlier than HBV DNA in some patients. However, there are limitations in the detection of serum HBV RNA levels and drug-resistant mutations compared to serum HBV DNA.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Zhanqing Zhang, Wei Lu, Dong Zeng, Dan Huang, Weijia Lin, Li Yan, Yanling Feng
Summary: Quantitative HBsAg is more valuable than HBV DNA in predicting significant hepatitis activity of HBeAg-positive chronic HBV infection, with higher sensitivity and specificity levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Percy A. Knolle, Li-Rung Huang, Anna Kosinska, Dirk Wohlleber, Ulrike Protzer
Summary: Chronic hepatitis B affects over 250 million individuals worldwide, with prophylactic vaccination only establishing protective immunity but not eliminating HBV infections in patients. Current research focuses on therapeutic vaccination strategies and additional immune stimulation measures to improve efficacy in treating chronic hepatitis B.
Article
Biochemistry & Molecular Biology
Keiji Ueda, Yadarat Suwanmanee
Summary: The precise mechanism of HBV entry into cells is still largely unknown. However, researchers have identified ATP5B as an essential factor for HBV entry, which is believed to bind with myristoylated preS1 2-47. Knockdown of ATP5B in NTCP-expressing HepG2 cells reduced HBV infectivity, indicating that ATP5B is involved in the HBV entry process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Yuan Zhang, Xiaorong Chen, Yajuan Cao, Zongguo Yang
Summary: APOBEC3 (A3) cytidine deaminases play important roles in inhibiting HBV infection, but their deaminated deoxycytidine activity can also cause cellular genetic mutations, affecting genomic stability and cancer development.
Article
Immunology
Hong Zhang, Fengjiao Wang, Xiaoxue Zhu, Yunfu Chen, Hong Chen, Xiaojiao Li, Min Wu, Cuiyun Li, Jingrui Liu, Yingjun Zhang, Yanhua Ding, Junqi Niu
Summary: The study demonstrates that GLS4 has antiviral activity in treating patients with chronic HBV infection, and the 120 mg GLS4 treatment regimen shows good tolerability.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Virology
Glenn Hogan, Benjamin Y. Winer, James Ahodantin, Julie Sellau, Tiffany Huang, Florian Douam, Masaya Funaki, Luis Chiriboga, Lishan Su, Alexander Ploss
Summary: Chronic hepatitis B (CHB), caused by hepatitis B virus (HBV), is a major medical problem that can lead to severe liver disease. In a humanized mouse model, we found that HBV infection can prime and expand immune cells, leading to immune activation.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Caorui Lin, Ying Huang, Linjie Luo, Fengling Fang, Jiawei Zhang, Zhen Xun, Ya Fu, Hongyan Shang, Can Liu, Qishui Ou
Summary: This study verified the diagnostic value of serum Adenosine Triphosphate (ATP) as a potential marker for differential HBV infection progress by detecting the level of ATP in the serum from a wide spectrum of HBV-infected populations, and confirmed the role of ATP in the deterioration of HBV infection-related diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Grant Tarnow, Alan McLachlan
Summary: Beta-catenin supports high levels of viral biosynthesis in the central vein region of the liver lobule, with its absence leading to reduced viral replication and expansion to other areas. The beta-catenin signaling pathway is a major determinant of HBV replication distribution in the liver lobule.
JOURNAL OF VIROLOGY
(2021)
Article
Virology
Sirinart Sirilert, Pattara Khamrin, Kattareeya Kumthip, Rungnapa Malasao, Niwat Maneekarn, Theera Tongsong
Summary: This study aimed to explore the role of HBV genotypes in the presence of HBV in the placenta and fetus. The results showed that subgenotype C1 was the most common in Northern Thai pregnant women, followed by subgenotype B9. HBV genotype B had a higher trend in intrauterine detection compared to genotype C. Furthermore, the placenta could possibly be a site of HBV accumulation, and mutation is unlikely to occur during intrauterine exposure.
Review
Oncology
Valentina Svicher, Romina Salpini, Stefano D'Anna, Lorenzo Piermatteo, Marco Iannetta, Vincenzo Malagnino, Loredana Sarmati
Summary: HBV is a highly prevalent hepatitis virus worldwide, and it has been clearly reported to be associated with chronic infection and liver cancer. This article reviews the most recent evidence from epidemiological and in vitro studies on the correlation between HBV infection and the development of lymphatic or hematologic malignancies. In terms of hematological malignancies, the strongest epidemiological correlations are observed with the emergence of lymphomas, particularly non-Hodgkin's lymphoma, while the associations with NHL T subtypes and leukemia remain questionable. HBV DNA has been found in peripheral blood mononuclear cells, suggesting its potential role in carcinogenesis. In vitro studies have also shown that HBV can infect lymphomonocytes and bone marrow stem cells, potentially acting as reservoirs for viral replication. Further research is needed to understand the pathogenic mechanisms and implications of the association between chronic HBV infection and hematological malignancies, which could have important implications for antiviral drugs and vaccines.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Homie A. Razavi, Maria Buti, Norah A. Terrault, Stefan Zeuzem, Cihan Yurdaydin, Junko Tanaka, Alessio Aghemo, Ulus S. Akarca, Nasser M. Al Masri, Abduljaleel M. Alalwan, Soo Aleman, Abdullah S. Alghamdi, Saad Alghamdi, Waleed K. Al-Hamoudi, Abdulrahman A. Aljumah, Ibrahim H. Altraif, Tarik Asselah, Ziv Ben-Ari, Thomas Berg, Mia J. Biondi, Sarah Blach, Wornei S. M. Braga, Carlos E. Brandao-Mello, Maurizia R. Brunetto, Joaquin Cabezas, Hugo Cheinquer, Pei-Jer Chen, Myeong-Eun Cheon, Wan-Long Chuang, Carla S. Coffin, Nicola Coppola, Antonio Craxi, Javier Crespo, Victor De Ledinghen, Ann-Sofi Duberg, Ohad Etzion, Maria Lucia G. Ferraz, Paulo R. A. Ferreira, Xavier Forns, Graham R. Foster, Giovanni B. Gaeta, Ivane Gamkrelidze, Javier Garcia-Samaniego, Liliana S. Gheorghe, Pierre M. Gholam, Robert G. Gish, Jeffrey Glenn, Julian Hercun, Yao-Chun Hsu, Ching-Chih Hu, Jee-Fu Huang, Naveed Janjua, Jidong Jia, Martin Kaberg, Kelly D. E. Kaita, Habiba Kamal, Jia-Horng Kao, Loreta A. Kondili, Martin Lagging, Pablo Lazaro, Jeffrey V. Lazarus, Mei-Hsuan Lee, Young-Suk Lim, Paul J. Marotta, Maria-Cristina Navas, Marcelo C. M. Naveira, Mauricio Orrego, Carla Osiowy, Calvin Q. Pan, Mario G. Pessoa, Giovanni Raimondo, Alnoor Ramji, Devin M. Razavi-Shearer, Kathryn Razavi-Shearer, Cielo Y. Rios-Hincapie, Manuel Rodriguez, William M. C. Rosenberg, Dominique M. Roulot, Stephen D. Ryder, Rifaat Safadi, Faisal M. Sanai, Teresa A. Santantonio, Christoph Sarrazin, Daniel Shouval, Frank Tacke, Tammo L. Tergast, Juan Miguel Villalobos-Salcedo, Alexis S. Voeller, Hwai-I Yang, Ming-Lung Yu, Eli Zuckerman
Summary: Hepatitis D virus (HDV) coinfection with hepatitis B increases the risk of liver cancer, cirrhosis, and death compared to hepatitis B monoinfection. Accurate estimates of HDV prevalence are needed to effectively identify coinfected individuals. Implementing double reflex testing, including anti-HDV testing and HDV RNA testing, is the most effective method to generate estimates and identify undiagnosed individuals. This strategy is feasible and requires a relatively low number of tests.
JOURNAL OF HEPATOLOGY
(2023)
Review
Virology
Marina Campos-Valdez, Hugo C. Monroy-Ramirez, Juan Armendariz-Borunda, Laura Sanchez-Orozco
Summary: Research on the immunopathogenesis and molecular mechanisms of hepatitis B virus (HBV) infection is complex, particularly due to difficulties in identifying patients at appropriate time points. Valuable data from animal and in vitro models has helped clarify some aspects of the early immune response. The diversity of HBV genotypes and variants is associated with disease development, outcomes, and treatment responses.
Article
Oncology
Emily R. Finch, Laura J. Janke, Lie Li, Monique A. Payton, David A. Jenkins, Kristine R. Crews, Mary Relling, Seth E. Karol
Summary: Based on the results of our preclinical murine studies, we conclude that dasatinib is unlikely to increase the osteonecrotic effects of dexamethasone in ALL regimens.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Immunology
Dan Zhang, Jie Yang, Yuanhui Zhao, Jinjun Shan, Lingling Wang, Guang Yang, Susu He, Erguang Li
Summary: Respiratory syncytial virus (RSV) infection can lead to the accumulation of eosinophils and other inflammatory cells in the lungs of neonatal mice, exacerbating the pathological changes of allergic asthma. Adoptive transfer of eosinophils from asthmatic mice with RSV infection can further enhance the pulmonary inflammatory response, but this can be effectively reduced by treatment with an anti-inflammatory drug.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dan Zhang, Yuanhui Zhao, Lingling Wang, Xiaoxin You, Jingjing Li, Guohai Zhang, Yayi Hou, Hongwei Wang, Susu He, Erguang Li
Summary: This study found that Axl acts as a suppressor of the antiviral response during RSV infection by negatively regulating IFN signaling.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lie Li, Jie Wang, Huishan Jiang, Xiaohong Wen, Mei Yang, Suping Li, Qiuping Guo, Kemin Wang
Summary: We developed a DNA tetrahedron-based split aptamer probe for ratiometric fluorescence imaging of ATP in living cells. This probe is highly biocompatible and can avoid false-positive signals from complex biological matrices.
CHINESE CHEMICAL LETTERS
(2023)
Article
Oncology
Hiroto Inaba, Jolieke G. van Oosterwijk, John C. Panetta, Lie Li, Daelynn R. Buelow, James S. Blachly, Sheila Shurtleff, Ching-Hon Pui, Raul C. Ribeiro, Jeffrey E. Rubnitz, Stanley Pounds, Sharyn D. Baker
Summary: The combination therapy of crenolanib and sorafenib shows good efficacy and tolerability in FLT3-ITD positive AML, with rare emergence of FLT3-KD mutations.
CLINICAL CANCER RESEARCH
(2022)
Article
Green & Sustainable Science & Technology
Lei Wang, Yigang He, Lie Li, Xiaoyan Liu, Yingying Zhao
Summary: This study proposes three improved encoder-decoder architectures for multi-step wind power predictions, using numerical weather predictions and wind power data from different wind farms. The correlations between datasets from multiple wind farms are analyzed, and a combination of manual experience and machine grid searches is used to optimize the proposed models' performance. The experimental results show that the Transformer model performs better in terms of prediction accuracy and computational efficiency, indicating its potential for large-scale wind farm applications.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Engineering, Electrical & Electronic
Lie Li, Yigang He, Lei Wang, Chuankun Wang, Xiaoyan Liu
Summary: This paper studies the failure probability distribution of IGBT devices, focusing on the impact of bonding wire and solder layer failures on the overall lifetime, and quantifies the relationship between the lifetime of each failed component and the IGBT's overall lifetime by exploring Weibull parameters and fitting coupling coefficients. Experimental results demonstrate the existence of the coupling effect and the superiority of the model in lifetime prediction.
MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
(2022)
Article
Microbiology
Yubin Zhao, Dawei Guan, Xu Liu, Gui-Feng Gao, Fangang Meng, Bingqiang Liu, Pengfei Xing, Xin Jiang, Mingchao Ma, Fengming Cao, Li Li, Jun Li
Summary: This study investigated the structure, assembly process, and interactions of rhizomicrobial communities in different soils. The results showed that co-inoculation increased the diversity and complexity of rhizomicrobial communities. In addition, co-inoculation increased the contribution of stochastic processes in the assembly of soil microorganisms and restricted the movement of pathogenic microorganisms. These findings support the feasibility of rebuilding the rhizosphere microbial system via specific microbial strain inoculation and provide important evidence for the sustainable development of agriculture.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Hongyi Zhou, Jie Li, Huabo Su, Ji Li, Todd A. Lydic, Martin E. Young, Weiqin Chen
Summary: This study identifies the crucial role of the BSCL2 gene in regulating cardiac substrate metabolism and contractile function. Deletion of the BSCL2 gene leads to cardiac dysfunction, which can be partially reversed by inhibiting fatty acid oxidation or a high-fat diet.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wenyi Hu, Hailong Su, Xiaojuan Zeng, Xinglian Duan, Yangqiu Li, Li Li
Summary: This study proposes a personal glucose meter-based exosome detection method with high sensitivity and reproducibility. It utilizes a catch probe and signal recycling to generate multiple DNAzyme sequences, which catalyze sucrose to glucose for detection on glucose meters. The method exhibits a wide detection range and low limit of detection.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Jianqiu Zou, Wenjuan Wang, Yi Lu, Juan Ayala, Kunzhe Dong, Hongyi Zhou, Jinxi Wang, Weiqin Chen, Neal L. Weintraub, Jiliang Zhou, Jie Li, Huabo Su
Summary: Cardiac maturation is regulated by neddylation, a post-translational modification process. Mosaic deletion of NAE1, a necessary enzyme for neddylation, in neonatal hearts leads to cardiomyopathy and heart failure. Neddylation is involved in transverse tubule formation, physiological hypertrophy, and fetal-to-adult isoform switching, promoting cardiac maturation through oxidative metabolism.
Article
Microbiology
Dan Zhang, Yuanhui Zhao, Xiaoxin You, Susu He, Erguang Li
Summary: RSV infection is a common pulmonary infection in infants and the elderly, but no specific therapeutics are available. In this study, Axl kinase inhibitors were found to reduce RSV infection and promote the expression of antiviral genes.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mengyu Zhang, Weikang Sun, Xiaoxin You, Dongge Xu, Lingling Wang, Jingping Yang, Erguang Li, Susu He
Summary: This study analyzed publicly available datasets and found that EBV-associated gastric cancer (EBVaGC) has a repression of L1 transcription compared with EBV-negative gastric cancer (EBVnGC). Retrotransposition-associated young and full-length L1s (FL-L1s) were found to be the most repressed L1s in EBVaGC. Increased deposition of H3K9me3 on FL-L1s was observed, potentially attributed to increased TASOR expression and the interaction between viral DNA and the TASOR enhancer. This study uncovers a regulation mechanism of L1 expression by chromatin topology remodeling associated with viral-host genome interaction in EBVaGC.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Plant Sciences
Li Li, Yaosheng Wang, Fulai Liu
Summary: Alternate partial root-zone N-fertigation improves nitrogen nutrition and changes grain quality in barley grown under elevated carbon dioxide and water deficit conditions. The effect of N-fertigation on grain quality formation and the role of endogenous ABA level need further exploration.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Feyisayo O. Adepoju, Kingsley C. Duru, Erguang Li, Elena G. Kovaleva, Mikhail V. Tsurkan
Summary: Betulin is a natural triterpene with potential wound healing properties. It has protective effects against various diseases such as cardiovascular and liver diseases, cancer, diabetes, oxidative stress, and inflammation. It can modify multiple pharmacological targets and has anti-inflammatory activity on signaling pathways like MAPK, NF-kappa B, and Nrf2.
