Article
Virology
Moonsik Kim, Nora Jee-Young Park, Ji Yun Jeong, Ji Young Park
Summary: Multiple HPV infections are associated with high-grade SIL and persistent HPV infection compared to single HPV infection, with distinct clinicopathologic characteristics. Close follow up and reporting of multiple HPV infection is warranted.
Article
Microbiology
Hongyu Xie, Mingjing Wei, Lifang Yao, Yi Liu, Xing Xie, Xiao Li
Summary: This study investigates the relationship between single nucleotide polymorphisms (SNPs) in human papillomavirus (HPV) receptor associated genes and HPV susceptibility and clinical outcomes in Chinese women, and explores a new triaging strategy for non-16/18 high-risk HPV infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Virology
Halimatou Diop-Ndiaye, Xavier Sastre-Garau, Aboubacry Drame, Birama Dembele, Nafissatou N. Ba, Oumy Diop-Diongue, Madeleine Mbow, Mba E. B. Diakhaby, Gisele Woto-Gaye, Coumba Toure Kane, Mamadou Diop
Summary: This study analyzed viral epidemiology of cervical neoplasia in Senegal and found that most HPV-positive cases were associated with viral genotypes covered by the 9-valent HPV vaccine, while 14.1% of cases remained HPV negative. Prophylactic vaccination using a 9-valent vaccine should reduce the incidence of HPV-associated neoplasia, but detection and treatment of CIN are still necessary for optimal prevention of cervical cancer.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Chenchen Ren, Xianxu Zeng, Zhongna Shi, Chunyan Wang, Huifen Wang, Xiuqin Wang, Baoping Zhang, Zhaoning Jiang, Huan Ma, Hao Hu, Haozhe Piao, Xiaoan Zhang, Baojin Wang
Summary: This study evaluated the diagnostic value of OCT in detecting cervical precancerous lesions and cancer, showing that OCT has good diagnostic accuracy and consistency, making it a potential cervical diagnosis method.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou
Summary: Persistent HPV infection is necessary but not sufficient for cervical cancer. Behavioral, environmental, or comorbid exposures may affect the development of cervical cancer. However, the validity of the observational studies describing these associations is still unclear.
Article
Virology
Xiao Tang, Terri E. Jones, Wei Jiang, Marshall Austin, Yanmei He, Lei Li, Lingling Tong, Cheng Wang, Kaixuan Yang, Rutie Yin, Chengquan Zhao
Summary: This study aimed to analyze the distribution of human papilloma virus (HPV) genotypes associated with cervical neoplasias and cancers in a major Chinese gynecologic center. The results showed a higher detection rate of high risk HPV in squamous cancers compared to cervical adenocarcinomas. Multiple HPV infections were more common in early stage cervical neoplasia and decreased with increasing severity of squamous lesions. HPV16 was one of the most common high risk HPV genotypes detected before any histopathologic abnormalities.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Veronique Bouvard, Nicolas Wentzensen, Anne Mackie, Johannes Berkhof, Julia Brotherton, Paolo Giorgi-Rossi, Rachel Kupets, Robert Smith, Silvina Arrossi, Karima Bendahhou, Karen Canfell, Z. Mike Chirenje, Michael H. Chung, Marta del Pino, Silvia de Sanjose, Miriam Elfstrom, Eduardo L. Franco, Chisato Hamashima, Francoise F. Hamers, C. Simon Herrington, Raul Murillo, Suleeporn Sangrajrang, Rengaswamy Sankaranarayanan, Mona Saraiya, Mark Schiffman, Fanghui Zhao, Marc Arbyn, Walter Prendiville, Blanca I. Indave Ruiz, Isabel Mosquera-Metcalfe, Beatrice Lauby-Secretan
Summary: This article reviews the best methods of screening for cervical cancer, with HPV nucleic acid testing being superior whether used alone or in combination with other methods.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Li Li, Mingyue Jiang, Tingyuan Li, Jian Yin, Ruimei Feng, Li Dong, Sufia Imam, Jianfeng Cui, Bin Liu, Xun Zhang, Qinjing Pan, Youlin Qiao, Wen Chen
Summary: This study investigated HPV genotype distribution among women aged 21 to 64 in Inner Mongolia and Shanxi Province in China who had not been vaccinated against HPV. The study found that HPV types 16, 52, 58, and 18 are common in the population and that HPV52 and 58 in the prophylactic HPV vaccine may enhance protection against cervical lesions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Rebecca B. Perkins, Nicolas Wentzensen, Richard S. Guido, Mark Schiffman
Summary: Each year in the US, about 100,000 people are treated for cervical precancer, 14,000 are diagnosed with cervical cancer, and 4,000 die from it. Almost all cervical cancers worldwide are caused by certain HPV genotypes. HPV vaccination at ages 9 to 12 can prevent over 90% of cervical precancers and cancers. Cervical cancer can be prevented through screening and treatment of cervical precancer in individuals with a cervix aged 21 to 65.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Public, Environmental & Occupational Health
Eliza Lai-Yi Wong, Annie Wai-Ling Cheung, Zigui Chen, Amy Yuen-Kwan Wong, Apple Chung-Man Yeung, Peter Sen-Yung Yau, Paul Kay-Sheung Chan
Summary: This study investigated HPV infection among Chinese women with cytological abnormalities and found an overall infection rate of 74%, with 2.3% being cutaneous HPV infection. The prevalence of HPV infection peaked in the 35-39 age group and gradually declined, with a second peak occurring at age 65 and above. HPV58, HPV52, HPV53, HPV16, and HPV18 were the most common high-risk genotypes among women with cytological abnormalities.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Flavia M. Correa, Arn Migowski, Liz M. De Almeida, Marcelo A. Soares
Summary: This review discusses the current strategies in Brazil for screening, treatment, and prevention (HPV vaccination) against cervical cancer, highlighting the country's large public health system and the disparities in access to healthcare. It also explores the potential integration of newer technologies to eliminate cervical cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yvonne T. Nartey, Kwabena H. Amo-Antwi, Philip M. Hill, Edward Dassah, Richard O. Asmah, Kofi Nyarko, Ramatu Agambire, Thomas Konney, Joel Yarney, Nelson Damale, Brian Cox
Summary: This study aimed to compare the distribution of high-risk human papillomavirus (HR-HPV) genotypes in women with and without cervical cancer in order to develop a population-based prevention strategy for cervical cancer in Ghana. The results showed that the most common HR-HPV genotypes among women with cervical cancer were 16, 18, 45, 35, and 52, while 66, 52, 35, 43, and 31 were frequently detected in women without cancer. HPV DNA testing and multivalent vaccines targeting HPV 16, 18, 45, and 35 genotypes are crucial for cervical cancer control in Ghana.
Article
Plant Sciences
Yunhua Liu, Pengfei Zheng, Tingting Jiao, Mengmeng Zhang, Yingjie Wu, Xinjiang Zhang, Shuyue Wang, Zongjiang Zhao
Summary: This study investigated the pharmacological mechanism of paiteling in regulating cervical cancer cell apoptosis. The results showed that paiteling can induce cervical cancer cell apoptosis by inhibiting the E6/E7-Pi3k/Akt signaling pathway, providing an effective alternative strategy of traditional Chinese medicine for the treatment of epithelial neoplasia caused by HPV infection.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Microbiology
Brhanu Teka, Kyoko Yoshida-Court, Ededia Firdawoke, Zewditu Chanyalew, Muluken Gizaw, Adamu Addissie, Adane Mihret, Lauren E. E. Colbert, Tatiana Cisneros Napravnik, Molly B. B. El Alam, Erica J. J. Lynn, Melissa Mezzari, Jhingran Anuja, Eva Johanna Kantelhardt, Andreas M. M. Kaufmann, Ann H. H. Klopp, Tamrat Abebe
Summary: This study aimed to compare the cervicovaginal microbiota in women with cervical cancer, premalignant dysplasia, and healthy women. The results showed differences in microbiota diversity, composition, and relative abundance among the three groups.
Article
Multidisciplinary Sciences
Jihoon Kim, Halim Jo, Min Chul Ha, Hyunil Kim, Jung Kuk Lee, Jae Hun Han, San-Hui Lee, Dae Ryong Kang, Su Young Kim, Hyun-Soo Kim, Hee Man Kim
Summary: This study investigated the association between ulcerative colitis (UC) and uterine cervical cancer in South Korean women using health insurance claims data. The results showed that UC patients had a higher risk of developing cervical cancer, especially among elderly patients and those with low socioeconomic status. Regular cervical cancer screening is recommended for elderly patients recently diagnosed with UC.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Dilipkumar Pal, Souvik Mukherjee, In-Ho Song, Satish B. Nimse
Summary: Alzheimer's disease is a common form of dementia caused by cognitive function impairment, with research suggesting the involvement of GSK-3 in the hyper-phosphorylation of tau proteins, making it a potential target for AD treatment. Inhibitors of GSK-3 have received significant attention for their potential therapeutic applications in AD and other diseases.
CURRENT DRUG TARGETS
(2021)
Review
Pharmacology & Pharmacy
Supriyo Saha, Dilipkumar Pal, Satish B. Nimse
Summary: The study examined the development of synthetic GSK-3 inhibitors for the prevention and treatment of neurological disorders, such as Alzheimer's disease and bipolar disorders. The synthesized molecules have shown remarkable effects in combating Alzheimer's, Parkinson's depression, psychosis, and other forms of neurological disorders.
CURRENT DRUG TARGETS
(2021)
Review
Chemistry, Medicinal
Supriyo Saha, Dilipkumar Pal, Satish Balasaheb Nimse
Summary: This manuscript focuses on the importance of indazole derivatives in the treatment of various gastrointestinal diseases. Different indazole derivatives play a critical role in the treatment of different diseases such as IBS, diarrhea, metabolic syndrome, and gastrointestinal cancers. By analyzing the receptors associated with gastrointestinal disorders, it was found that indazole derivatives can effectively interact with the receptors.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Jung-Seop Lee, In-ho Song, Shrikant Dashrath Warkad, Gyu Seong Yeom, Pramod B. Shinde, Keum-soo Song, Satish Balasaheb Nimse
Summary: In this study, a series of 2,5-substituted-1H-benzo[d]imidazole derivatives were synthesized and it was demonstrated that compounds B15, B16, B19, and B20 exhibit excellent anticancer activity.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Chemistry, Analytical
Keum-Soo Song, Satish Balasaheb Nimse, Shrikant Dashrath Warkad, Jung-Hoon Kim, Hey-Jin Kim, Taisun Kim
Summary: Lung cancer is a leading cause of death globally. Low-dose computed tomography (LDCT) reduces lung cancer mortality by 20% compared to standard chest X-rays among current or heavy smokers, but has a high false-positive rate. This study presents a method based on biomarker detection to complement LDCT for detecting various stages of lung cancer.
Article
Biochemistry & Molecular Biology
Dilipkumar Pal, In-ho Song, Shrikant Dashrath Warkad, Keum-soo Song, Gyu Seong Yeom, Supriyo Saha, Pramod B. Shinde, Satish Balasaheb Nimse
Summary: This review presents the research advances on compounds containing indazole scaffolds as microtubule targeting agents based on articles published in the last two decades. Several compounds have shown potent microtubule inhibition and anticancer activity, with some of them having the lowest IC50 values observed in cell line studies.
BIOORGANIC CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Supriyo Saha, Gyu Seong Yeom, Satish Balasaheb Nimse, Dilipkumar Pal
Summary: The manuscript focuses on providing clues to enhance the innate immunity of coronavirus patients and protect them from new mutant strains and black fungus infections. Through molecular docking studies, potential therapeutic candidates for COVID-19 and drugs for treating black fungus infections were identified. The combined therapy of ledipasvir and itraconazole could be a better alternative for treating COVID-19 patients coinfected with black fungus.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Analytical
In-ho Song, Gyu Seong Yeom, Anil Kuwar, Satish Balasaheb Nimse
Summary: In this study, a benzimidazole-based compound and its derivative probe were synthesized for the highly selective detection and quantification of cysteine in human serum. The derivative probe showed high selectivity and sensitivity for cysteine and achieved lower detection limits compared to reported methods in serum samples.
Article
Biochemistry & Molecular Biology
Kundan Tayade, Gyu-Seong Yeom, Suban K. Sahoo, Horst Puschmann, Satish Balasaheb Nimse, Anil Kuwar
Summary: This study synthesized Schiff base compound 2 and determined its crystal structure and molecular structure. The antioxidant activity of this compound was confirmed through calculations and experiments. The compound exhibited excellent antioxidant activity and low cytotoxicity.
Article
Chemistry, Analytical
Prasad M. Sonawane, Neha Jain, Arkaprava Roychaudhury, Su Jeong Park, Vikas K. Bhosale, Mahesh B. Halle, Cheol-Hee Kim, Satish Balasaheb Nimse, David G. Churchill
Summary: This study introduces the synthesis and application of a highly sensitive fluorescence turn-on probe, Myco-OCl, for the specific and rapid detection of HOCl. The probe shows exceptional performance and has been successfully applied for live cell imaging and detection of HOCl in a zebrafish model.
Article
Chemistry, Analytical
Prasad M. Sonawane, Neha Jain, Arkaprava Roychaudhury, Su Jeong Park, Vikas K. Bhosale, Mahesh B. Halle, Cheol-Hee Kim, Satish Balasaheb Nimse, David G. Churchill
Summary: This study introduces a highly sensitive fluorescence turn-on probe, Myco-OCl, for detecting HOCl with exceptional specificity and rapid response. The probe has great potential for detecting HOCl in diverse physiological systems.
Article
Chemistry, Medicinal
Keum-soo Song, Satish Balasaheb Nimse, Junghoon Kim, Shrikant Dashrath Warkad, Taisun Kim
Summary: The developed ID-Checker enables highly specific delivery of anticancer agents to cancer cells through GLUT channels, resulting in cancer cell death within a short period of time without causing damage to normal cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Manohar Patil, Su Jeong Park, Gyu Seong Yeom, Ratnamala Bendre, Anil Kuwar, Satish Balasaheb Nimse
Summary: A Schiff base ligand FHE was synthesized and showed specific complex formation with Zn2+ ions, resulting in enhanced fluorescence. FHE demonstrated high sensitivity for detecting Zn2+ ions in living cells and environmental samples.
NEW JOURNAL OF CHEMISTRY
(2022)
Correction
Materials Science, Multidisciplinary
In-ho Song, Pritam Torawane, Jung-Seop Lee, Shrikant Dashrath Warkad, Amulrao Borase, Suban K. Sahoo, Satish Balasaheb Nimse, Anil Kuwar
Summary: The study successfully detected Al3+ and Cu2+ ions using isonicotinohydrazide-based chemosensors and applied them to live-cell imaging.
MATERIALS ADVANCES
(2021)
Article
Materials Science, Multidisciplinary
In-ho Song, Pritam Torawane, Jung-Seop Lee, Shrikant Dashrath Warkad, Amulrao Borase, Suban K. Sahoo, Satish Balasaheb Nimse, Anil Kuwar
Summary: The newly synthesized Schiff base receptor 3 exhibits excellent selectivity and sensitivity towards Cu2+ and Al3+ ions through UV-vis absorption and fluorescence spectroscopy, respectively. It shows detectable color changes and significant fluorescent enhancement in the presence of these ions, with a much lower limit of detection for Al3+ ions.
MATERIALS ADVANCES
(2021)
Article
Biochemical Research Methods
Atif Khurshid Wani, Chirag Chopra, Daljeet Singh Dhanjal, Nahid Akhtar, Himanshu Singh, Poorvi Bhau, Anjuvan Singh, Varun Sharma, Rafael Silvio Bonilha Pinheiro, Juliana Heloisa Pine Americo-Pinheiro, Reena Singh
Summary: Zoonotic viral infections pose significant threats to global public health. Understanding the origins and dynamics of these infections is crucial for prevention and management of future outbreaks. Metagenomics is a powerful tool for studying the diversity of viral populations and potential zoonotic events.
JOURNAL OF VIROLOGICAL METHODS
(2024)
Article
Biochemical Research Methods
Michel V. F. Sucupira, Ana P. C. Argondizzo, Mariana Miguez, Anna E. de Araujo, Leila B. R. Silva, Marcelle B. Mello, Christiane F. S. Marques, Danielle Brito Cunha, Renata C. Bastos, Vanessa S. de Paula, Luciane A. Amado Leon
Summary: This study focuses on improving the purification, solubility, and protein expression levels of recombinant VP1-2A, a hepatitis A virus (HAV) structural protein with immunogenic activity. The results show that the modified approach successfully produces biologically active HAV VP1-2A, which can be used as a diagnostic tool for HAV infection.
JOURNAL OF VIROLOGICAL METHODS
(2024)
Article
Biochemical Research Methods
Arun K. Dhar, Roberto Cruz-Flores, Hung N. Mai, Janet Warg
Summary: A sensitive and robust TaqMan PCR method for detecting IHHNV in three commercially important shrimp species was developed and compared with other published methods. Multiple primer/probe sets, including qIH-Fw/qIH-Rv and 3144F/3232R, are recommended for the detection of IHHNV. These findings are valuable for large-scale screening of shrimp using a TaqMan real-time PCR assay.
JOURNAL OF VIROLOGICAL METHODS
(2024)
Article
Biochemical Research Methods
Kemal Mehinagic, Matthias Liniger, Maksym Samoilenko, Nick Soltermann, Markus Gerber, Nicolas Ruggli
Summary: A plasmid-based reporter assay has been developed for sensitive detection and titration of infectious African swine fever virus (ASFV). This novel method allows accurate measurement of ASFV titers and is applicable to ASFV of different genotypes, virulence, and sources.
JOURNAL OF VIROLOGICAL METHODS
(2024)
Article
Biochemical Research Methods
Jan Van Slambrouck, Charlotte Schoenaers, Lies Laenen, Xin Jin, Kurt Beuselinck, Ann Verdonck, Joost Wauters, Geert Molenberghs, Bart M. Vanaudenaerde, Robin Vos, Peter Mombaerts, Katrien Lagrou, Laurens J. Ceulemans
Summary: The ability to detect SARS-CoV-2 RNA or antigen in BAL fluid samples using point-of-care tests (POCTs) can reduce the risk of developing severe COVID-19 after lung transplantation.
JOURNAL OF VIROLOGICAL METHODS
(2024)
