期刊
JOURNAL OF VIRAL HEPATITIS
卷 20, 期 4, 页码 e78-e81出版社
WILEY
DOI: 10.1111/jvh.12012
关键词
direct acting antivirals; durable; hepatitis C; sustained virologic response
资金
- Foundation for Liver Research, Rotterdam, the Netherlands
Achievement of a sustained virologic response (SVR) after peginterferon (PEG-IFN) and ribavirin (RBV) treatment is considered to be a marker for the cure of chronic hepatitis C virus (HCV) infection. Long-term follow-up of patients with SVR after treatment with a direct acting antiviral has not yet been described. We used a randomized placebo-controlled, double-blind, two-period phase 1b trial that was conducted in 40 HCV genotype 1 (treatment-naive and treatment-experienced)-infected patients. Nineteen patients achieved SVR after treatment with the HCV protease inhibitor narlaprevir followed by PEG-IFN/RBV. In these patients, HCV-RNA tests were scheduled at 3, 6, 12 and 24months after end of treatment. Patients were followed for a median of 27months (range 1532) after end of treatment with a median number of follow-up visits of 4 (range 38). All patients remained HCV-RNA negative over time. SVR achieved following narlaprevir and PEG-IFN/RBV-therapy was durable up to 32months after the end of treatment.
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