Article
Virology
Chia-Min Wu, Fu-Hsiung Su, Chih-Hsin Muo, Jou-Chen Huang, Meei-Maan Wu, Chih-Ching Yeh
Summary: This study found that patients with HCV infection treated with PegIFN/RBV therapy had a significantly increased risk of retinopathy, particularly retinal hemorrhage.
Review
Virology
Yi-Wen Huang, Albert Qin, Chan-Yen Tsai, Pei-Jer Chen
Summary: Ropeginterferon alfa-2b is a promising treatment option for MPN and chronic viral hepatitis due to its favorable pharmacokinetic profile and demonstrated efficacy in clinical studies. Administered once every two weeks, it has shown to be well-tolerated and effective in treating chronic hepatitis B, C, and D.
Review
Gastroenterology & Hepatology
Lisa Sandmann, Heiner Wedemeyer
Summary: Interferon-alfa has been the main treatment for hepatitis D virus (HDV) infection, but only a portion of patients benefit from it. Successful interferon treatment is associated with improved long-term clinical outcomes. Although alternative treatments are being developed, pegylated interferon-alfa still plays an important role. There is a need for better biomarkers to select patients who are likely to benefit from interferon-based treatments.
LIVER INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Ming-Han Hsieh, Tzu-Yu Kao, Ting-Hui Hsieh, Chun-Chi Kao, Cheng-Yuan Peng, Hsueh-Chou Lai, Po-Heng Chuang, Jung-Ta Kao
Summary: SVR lowers the risk of liver histological progression but does not guarantee fibrosis clearance. For SVR cases, those with baseline F >= 2 or without significantly declined follow-up AST levels should be specifically monitored. As for non-SVR cases, those with a higher baseline AST or glucose level should preferentially receive retreatment.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2022)
Article
Virology
Ahmed M. Mostafa, Hesham A. Saafan, Ahmed S. Al-Tawashi, Muhannad H. Kasem, Ahmed M. Alaa, Mahmoud M. Eltobgy, Ahmed S. Moubarak, Manar M. Gharib, Mohamed A. Awwad, Hazem M. Omar, Marwa O. El-Derany
Summary: This study aimed to investigate the association between haplotypes in IL-17A receptor rs2275913 and rs3819024 and development of HCC in CHC patients treated with either triple therapy or with dual therapy. The results showed that the presence of G-G haplotype in IL-17A was inversely associated with HCC development in patients receiving triple therapy. High serum AFP levels were directly associated with HCC development in patients receiving triple therapy.
Article
Virology
Mengqi Luo, Lingyan Zhang, Chou Yang, Bin Zhou, Jinlin Hou, De-Ke Jiang
Summary: This study found that single-nucleotide polymorphism CXCL13_rs76084459 is significantly associated with response to PegIFNa therapy in patients with chronic hepatitis B. Furthermore, a polygenic score composed of 6 SNPs including CXCL13_rs76084459 has a better predictive value for PegIFNa treatment response.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Yu Liu, Hui Chen, Zhi-Ying Xu
Summary: This is a case of a patient who developed ischemic colitis during pegylated interferon-alpha (PEG-IFN-alpha) therapy. The patient presented with acute lower abdominal pain and haematochezia while receiving PEG-IFN-alpha monotherapy for chronic hepatitis B. Diagnosis was confirmed through colonoscopy and biopsies, and treatment involved discontinuation of PEG-IFN-alpha and symptomatic management. The patient recovered and subsequent colonoscopy showed normal findings.
Article
Public, Environmental & Occupational Health
Yadong Wang, Yangyang Hu, Xing Zhang, Yue Luo, Luyuan Ma, Jingjing Lu, Qianfei Liang, Chengjun Xu, Caiyan Zhao, Calvin Q. Pan
Summary: This study investigated the relationship between IP-10 and treatment response in patients with CHC treated with direct-acting antiviral agents. The results showed that IP-10 levels decreased gradually during the treatment and baseline IP-10 level and the decline at 12 weeks were independent predictors of SVR.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Gastroenterology & Hepatology
Cai-Zhi Huang, Jie Zhang, Lin Zhang, Cui-Hua Yu, Yi Mo, Li-Ya Mo
Summary: Children with CHB have lower serum levels of 25(OH)D and VDBP than healthy controls. VDBP levels are negatively correlated with HBV replication, while low 25(OH)D levels are independently associated with hepatic fibrosis in children with CHB. There is no significant correlation between serum levels of 25(OH)D and VDBP.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Penglei Jiang, Hongyu Jia, Xinyue Qian, Tian Tang, Yingli Han, Zhaoru Zhang, Lingli Jiang, Zebin Yu, Lin Zheng, Guodong Yu, Huan Cai, Shanyan Zhang, Xiaoli Zhang, Jueqing Gu, Chanyuan Ye, Lisha Yang, Yingfeng Lu, Heng Liu, Xiaoqing Lu, Ciliang Jin, Yue Ren, Miaomiao Lu, Lingling Xu, Jiong Yu, Xi Jin, Yida Yang, Pengxu Qian
Summary: This study used single-cell RNA sequencing to investigate the transcriptomic landscape of peripheral immune cells in CHB patients before and after PegIFN-alpha therapy. The study identified specific cell subsets associated with CHB and found that PegIFN-alpha treatment could decrease hyperactivated monocytes, increase long-lived naive/memory T cells, and enhance effector T cell cytotoxicity. Furthermore, the treatment altered the transcriptional profiles of immune cells and enhanced innate antiviral response.
Article
Chemistry, Multidisciplinary
Hafiza Rida Farooq Chudhary, Amjad Ali, Sadia Bibi, Muhammad Waqas, Shazia Rafique, Muhammad Idrees, Sobia Ahsan Halim, Magda H. Abdellattif, Ajmal Khan, Ahmed Al-Harrasi
Summary: HCV is a global public health problem with a high number of infections worldwide. It is a leading cause of liver cancer due to the frequent occurrence of HCV infection, especially in those with HCV cirrhosis. This study analyzed the transcriptional analysis of the TP53 gene in HCV-infected patients treated with different antiviral therapies. The results showed that TP53 expression was significantly upregulated in patients with virological responses and HCC, and sofosbuvir + daclatasvir treatment had a significant impact on TP53 expression.
Review
Immunology
Mamun Al-Mahtab, Sheikh Mohammad Fazle Akbar, Osamu Yoshida, Julio Cesar Aguilar, Gerardo Guillen, Yoichi Hiasa
Summary: An open-level clinical trial has shown that a therapeutic vaccine, NASVAC, containing HBsAg and HBcAg, is effective and safer than Peg-IFN in treating CHB patients. The study also suggests that NASVAC may be particularly beneficial for patients with HBV genotype-D.
Review
Cell Biology
Peter Ferenci, Thomas Reiberger, Mathias Jachs
Summary: Bulevirtide is a potential effective drug for the treatment of HDV infection by blocking the entry of HBV and HDV into cells. Clinical trials and real-world experiences have shown that the use of BLV alone or in combination with pegIFN alpha can effectively reduce HDV viremia and normalize ALT levels in patients.
Article
Biochemistry & Molecular Biology
Bernhard Schlevogt, Klaus H. W. Boeker, Stefan Mauss, Hartwig Klinker, Renate Heyne, Ralph Link, Karl-Georg Simon, Christoph Sarrazin, Yvonne Serfert, Michael P. Manns, Heiner Wedemeyer
Summary: The study indicates that patients receiving interferon-free antiviral treatment for chronic hepatitis C experience significant weight gain during long-term follow-up, with non-obese patients being more vulnerable to weight gain. A body mass index (BMI) < 30 was the only consistent predictor for weight gain, suggesting that non-obese individuals are more likely to gain weight after DAA treatment.
Article
Pharmacology & Pharmacy
Aigerim Abdrakhman, Aiymkul Ashimkhanova, Wassim Y. Almawi
Summary: The study shows that peginterferon has limited effectiveness in the treatment of chronic HDV, with only one-third of patients achieving viral clearance and normalization of ALT levels. Furthermore, HBsAg clearance with seroconversion to anti-HBs is rarely observed among chronic HDV patients.
ANTIVIRAL RESEARCH
(2021)
Article
Surgery
Yuki Okamoto, Shiro Oka, Shinji Tanaka, Shinji Nagata, Masaki Kunihiro, Toshio Kuwai, Yuko Hiraga, Seiji Onogawa, Takeshi Mizumoto, Hideharu Okanobu, Morihisa Akagi, Kazuaki Chayama
Summary: This study investigated the clinical outcomes of hybrid ESD for colorectal tumors that met the 30 mm lesion size criterion. The salvage group had a higher perforation rate overall, but a lower rate during snaring. During the second period compared to the first, there were significantly higher complete en bloc resection rates and experienced operator rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Naruhiko Honmyo, Tsuyoshi Kobayashi, Shintaro Kuroda, Kentaro Ide, Masahiro Ohira, Hiroyuki Tahara, Hiroshi Morimoto, Naoki Tanimine, Michinori Hamaoka, Megumi Yamaguchi, Masateru Yamamoto, Daisuke Takei, Hiroshi Aikata, Kazuaki Chayama, Hideki Ohdan
Summary: This study identified risk factors for hepatocellular carcinoma (HCC) development after splenectomy for portal hypertension. The etiology of cirrhosis, presence of HCC history, and preoperative hemoglobin level were found to be associated with HCC development. The predictive model constructed in this study may assist in surveillance for HCC after splenectomy in patients with portal hypertension.
Article
Gastroenterology & Hepatology
Tongqi Qian, Naoto Fujiwara, Bhuvaneswari Koneru, Atsushi Ono, Naoto Kubota, Arun K. Jajoriya, Matthew G. Tung, Emilie Crouchet, Won-Min Song, Cesia Ammi Marquez, Gayatri Panda, Ayaka Hoshida, Indu Raman, Quan-Zhen Li, Cheryl Lewis, Adam Yopp, Nicole E. Rich, Amit G. Singal, Shigeki Nakagawa, Nicolas Goossens, Takaaki Higashi, Anna P. Koh, C. Billie Bian, Hiroki Hoshida, Parissa Tabrizian, Ganesh Gunasekaran, Sander Florman, Myron E. Schwarz, Spiros P. Hiotis, Takashi Nakahara, Hiroshi Aikata, Eisuke Murakami, Toru Beppu, Hideo Baba, Rew Warren, Sangeeta Bhatia, Masahiro Kobayashi, Hiromitsu Kumada, Austin J. Fobar, Neehar D. Parikh, Jorge A. Marrero, Steve Hategekimana Rwema, Venugopalan Nair, Manishkumar Patel, Seunghee Kim-Schulze, Kathleen Corey, Jacqueline G. O'Leary, Goran B. Klintmalm, David L. Thomas, Mohammed Dibas, Gerardo Rodriguez, Bin Zhang, Scott L. Friedman, Thomas F. Baumert, Bryan C. Fuchs, Kazuaki Chayama, Shijia Zhu, Raymond T. Chung, Yujin Hoshida
Summary: This study developed a surrogate biomarker to predict liver fibrosis progression and evaluated the effectiveness of antifibrotic drugs. Results showed that a 20-gene surrogate biomarker could accurately predict fibrosis progression within 5 years. Furthermore, rational combination therapies based on epigallocatechin gallate were identified and validated for enhanced antifibrotic effect. This biomarker has potential clinical significance for the development of antifibrotics.
Article
Peripheral Vascular Disease
Yiming Han, Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Farina Mohamad Yusoff, Yukiko Nakano, Kazuaki Chayama, Ayumu Nakashima, Chikara Goto, Kenichi Yoshimura, Yukihito Higashi
Summary: This study investigated the association of isolated diastolic hypertension with endothelial function according to two major hypertension guidelines. The results showed that isolated diastolic hypertension was not associated with endothelial dysfunction in individuals who were not treated with antihypertensive drugs.
HYPERTENSION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Takahiro Harada, Masato Kajikawa, Tatsuya Maruhashi, Shinji Kishimoto, Takayuki Yamaji, Yiming Han, Aya Mizobuchi, Yu Hashimoto, Kenichi Yoshimura, Yukiko Nakano, Kazuaki Chayama, Chikara Goto, Farina Mohamad Yusoff, Ayumu Nakashima, Yukihito Higashi
Summary: This study revealed an inverse association between height and the risk of cardiovascular disease in Japanese men. Taller individuals had significantly higher flow-mediated vasodilation values compared to shorter individuals. Shorter individuals may require intensive interventions to reduce the risk of cardiovascular events.
HYPERTENSION RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Yutaro Ogawa, Takashi Nakahara, Masafumi Ono, Takumi Kawaguchi, Hiroshi Isoda, Akira Hiramatsu, Shinsuke Uchikawa, Hatsue Fujino, Eisuke Murakami, Tomokazu Kawaoka, Masami Yamauchi, Masataka Tsuge, Kensuke Munekage, Tsunehiro Ochi, C. Nelson Hayes, Michio Imamura, Hiroshi Aikata, Hirokazu Takahashi, Takuji Torimura, Kazuaki Chayama
Summary: This study evaluated blood glucose variability in patients with chronic liver disease using a continuous glucose monitoring system (CGMS) and examined the discrepancy between hemoglobin A1c (HbA1c) levels estimated from average blood glucose levels and HbA1c. The results showed that as hepatic functional reserve decreased, average blood glucose and insulin resistance increased while HbA1c decreased. A formula was created to calculate HbA1c without using CGMS. CGMS was useful in assessing accurate glycemic control and detecting hyperglycemia and hypoglycemia. Correction of hepatic functional reserve is necessary for glycemic control in patients with chronic liver disease.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Naohiro Kamiya, Takahiko Sugimoto, Hiromi Abe-Chayama, Rie Akiyama, Yasunori Tsuboi, Akira Mogami, Michio Imamura, C. Nelson Hayes, Kazuaki Chayama
Summary: In this study, a robust method was established to untie mature rcDNA into linear DNA, which can be used for quantification and visualization of cccDNA. Precise quantification was achieved by combining the method with plasmid-safe DNase and T5 exonuclease preprocessing and digesting cccDNA with a restriction enzyme. The method was successfully applied to an infection model and demonstrated the possibility of evaluating cccDNA levels accurately.
JOURNAL OF GENERAL VIROLOGY
(2022)
Correction
Gastroenterology & Hepatology
Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Nao Nishida, Seik-Soon Khor, Olivier Gervais, Yosuke Kawai, Masao Nagasaki, Katsushi Tokunaga, Ruqi Tang, Yongyong Shi, Zhiqiang Li, Brian D. Juran, Elizabeth J. Atkinson, Alessio Gerussi, Marco Carbone, Rosanna Asselta, Angela Cheung, Mariza de Andrade, Aris Baras, Julie Horowitz, Manuel A. R. Ferreira, Dylan Sun, David E. Jones, Steven Flack, Ann Spicer, Victoria L. Mulcahy, Jinyoung Byun, Younghun Han, Richard N. Sandford, Konstantinos N. Lazaridis, Christopher I. Amos, Gideon M. Hirsch, Michael F. Seldin, Pietro Invernizzi, Katherine A. Siminovitch, Xiong Ma, Minoru Nakamura, George F. Mells
JOURNAL OF HEPATOLOGY
(2022)
Article
Infectious Diseases
Haruna Hatooka, Yumi Shimomura, Michio Imamura, Yuji Teraoka, Kei Morio, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka, Grace Naswa Makokha, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiromi Abe-Chayama, C. Nelson Hayes, Hiroshi Aikata, Shinji Tanaka, Kazuaki Chayama
Summary: The study developed an antibody against preS1 and an ELISA system for measuring serum preS1 levels. PreS1 may serve as a novel tool to predict the need for antiviral therapy in HBeAg-negative HBV-infected patients.
JOURNAL OF INFECTION
(2022)
Article
Virology
Toshitada Takemori, Akiko Sugimoto-Ishige, Hironori Nishitsuji, Yushi Futamura, Michishige Harada, Tomomi Kimura-Someya, Takehisa Matsumoto, Teruki Honma, Miho Tanaka, Masami Yaguchi, Kyoichi Isono, Haruhiko Koseki, Hiroyuki Osada, Daiki Miki, Takashi Saito, Takashi Tanaka, Takehiro Fukami, Toshio Goto, Mikako Shirouzu, Kunitada Shimotohno, Kazuaki Chayama
Summary: Entry inhibitors are being developed to enhance the treatment of HBV patients with oral nucleoside/nucleotide analogues (NA). Therapeutic MAbs with neutralizing activity against HBs antigens have been developed to amplify the effectiveness of NA therapy. Targeting NTCP can provide an effective treatment option for patients with chronic hepatitis B, regardless of viral genotype, mutations, and the presence of subviral particles.
JOURNAL OF VIROLOGY
(2022)
Review
Gastroenterology & Hepatology
C. Nelson Hayes, Michio Imamura, Junko Tanaka, Kazuaki Chayama
Summary: Since its discovery in 1989, the road to a cure for hepatitis C virus (HCV) has been slow, but most patients can now expect to achieve a sustained virological response (SVR). Adverse events are rare or mild, and patients with compensated cirrhosis and other co-morbidities are often eligible for treatment. However, a small number of patients fail to eradicate the virus even after retreatment.
LIVER INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Kenji Yamaoka, Kenichiro Kodama, Tomokazu Kawaoka, Masanari Kosaka, Yusuke Johira, Yuki Shirane, Ryoichi Miura, Shigeki Yano, Serami Murakami, Kei Amioka, Kensuke Naruto, Yuwa Ando, Yumi Kosaka, Shinsuke Uchikawa, Takuro Uchida, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami, Wataru Okamoto, Masami Yamauchi, Daiki Miki, Michio Imamura, Shoichi Takahashi, Akiko Nagao, Kazuaki Chayama, Hiroshi Aikata
Summary: The study found that assessing body composition before and after lenvatinib treatment using BIA can be useful in predicting prognosis in patients with hepatocellular carcinoma.
Article
Endocrinology & Metabolism
Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Yukiko Nakano, Masato Kajikawa, Kenichi Yoshimura, Gaku Aoki, Kazuaki Chayama, Chikara Goto, Aya Mizobuchi, Yiming Han, Farina Mohamad Yusoff, Shinji Kishimoto, Tatsuya Maruhashi, Ayumu Nakashima, Yukihito Higashi
Summary: This study investigated the relationship between HbA1c levels and vascular function in patients with type 2 diabetes mellitus receiving antidiabetic drug treatment. Results showed an inverted U-shaped association between HbA1c levels and FMD, with both low (<6.5%) and high (>= 8.0%) HbA1c levels associated with endothelial dysfunction, while vascular smooth muscle function was similar regardless of HbA1c levels.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Genetics & Heredity
Hiroki Kiyose, Hidewaki Nakagawa, Atsushi Ono, Hiroshi Aikata, Masaki Ueno, Shinya Hayami, Hiroki Yamaue, Kazuaki Chayama, Mihoko Shimada, Jing Hao Wong, Akihiro Fujimoto
Summary: This study utilized the Oxford Nanopore sequencer to analyze cDNA sequences from hepatocellular carcinoma and matched non-cancerous livers, revealing numerous novel transcripts and thousands of differentially expressed transcripts. Experimental results demonstrated that differentially expressed transcripts can promote cell growth, and fusion gene detection uncovered novel fusion events.
Article
Peripheral Vascular Disease
Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Yuji Takaeko, Takayuki Yamaji, Takahiro Harada, Yu Hashimoto, Yiming Han, Yoshiki Aibara, Farina Mohamad Yusoff, Yukiko Nakano, Kazuaki Chayama, Ayumu Nakashima, Chikara Goto, Kenichi Yoshimura, Yukihito Higashi
Summary: The study showed a significant positive correlation between serum potassium levels and vascular function, with maintaining serum potassium levels of 4.5-<5.0 mmol/L associated with better vascular function.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)