期刊
JOURNAL OF VIRAL HEPATITIS
卷 18, 期 8, 页码 587-594出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2893.2010.01338.x
关键词
acute liver failure; acute viral hepatitis; cytotoxic T lymphocytes; immunohistochemistry
资金
- Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India
Hepatitis E virus infection (HEV) is a major cause of acute viral hepatitis in the developing world. The immunopathology of HEV infections has not yet been elucidated. The virus is noncytopathic, and therefore, liver injury may be attributed to immune-mediated damage by cytotoxic T cells and natural killer cells. Therefore, we studied the nature of immune cells involved in HEV-induced liver damage using immunohistochemistry in liver biopsies taken from patients with HEV-induced acute liver failure and demonstrated a significant infiltration of activated CD8(+) T cells containing granzymes. These findings suggest the possible involvement of cytotoxic T cells in disease pathogenesis during HEV infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据