期刊
JOURNAL OF VIRAL HEPATITIS
卷 17, 期 7, 页码 453-458出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2893.2010.01313.x
关键词
HBV; HCV; PD-1; PD-L1; T cell
Dysfunctional virus-specific T cells are a hallmark of many chronic viral infections. Recent studies have implicated the inhibitory PD-1/PD-L1 pathway with the functional impairment of T cells. In this respect, we will review the latest research on PD-1/PD-L1 pathway and T-cell exhaustion in the context of human chronic hepatitis B and C virus infections. We will also discuss the therapeutic potential of PD-1 blockade and how it may be enhanced through the modulation of other co-stimulatory/inhibitory pathways.
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