Article
Immunology
Matthew E. Brown, Leeana D. Peters, Seif R. Hanbali, Juan M. Arnoletti, Lindsey K. Sachs, Kayla Q. Nguyen, Emma B. Carpenter, Howard R. Seay, Christopher A. Fuhrman, Amanda L. Posgai, Melanie R. Shapiro, Todd M. Brusko
Summary: This study found that isolating Tregs using a CD4(+)CD25(+)CD226(-) strategy leads to a population with increased purity, lineage stability, and suppressive capabilities, which may be beneficial for the treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shi-Peng Li, Jin-Ming Zhang, Xiao-Jie Chen, Guang-Peng Zhou, Jie Sun, Bin Cui, Liu-Xin Zhou, Hai-Ming Zhang, Wei-Tao Que, Li-Ying Sun, Zhi-Jun Zhu
Summary: DPT cells are increased in liver transplant patients, especially in rejection cases. These cells show contiguity with Treg cells and their exhaustion is enhanced by increased PD-1 expression. These findings suggest that DPT cells may play a role in immune tolerance and could be targeted for preventing liver transplant rejection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qianqian Yang, Meihui Li, Ming Zhao, Feifan Lu, Xiaomin Yu, Li Li, Zhongyi Gu, Yifang Deng, Rui Guan
Summary: This study found that progesterone supplementation can promote pregnancy immune homeostasis by up-regulating Treg cells and TGF-beta 1 expression, which may be one of the mechanisms for preventing spontaneous preterm birth (sPTB).
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hilary R. Keller, Davinna L. Ligons, Can Li, SuJin Hwang, Megan A. Luckey, Praveen Prakhar, Nurcin Liman, Assiatu Crossman, Vanja Lazarevic, Yoo Kyoung Park, Jung-Hyun Park
Summary: The regulatory mechanism of CD103 expression differs between CD4 and CD8 T cells, with the transcription factor Runx3 playing an important but non-essential role. Integrin beta 7 availability is crucial for CD103 surface expression, and forced CD103 expression impairs the generation of MHC-II-restricted TCR transgenic T cells. Overexpression of CD103 does not significantly affect CD4 T cells in peripheral tissues, suggesting they may use CD103-independent pathways for tissue retention.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Zhenhua Deng, Jinren Zhou, Xiaoxin Mu, Jian Gu, Xiangyu Li, Qing Shao, Jinyang Li, Chao Yang, Guoyong Han, Jie Zhao, Yongxiang Xia
Summary: The co-infusion of hAMSC and Treg was found to prevent liver fibrosis, with Treg improving the function of hAMSC by regulating the TGF-β-IDO signaling. This provides a promising approach for treating liver cirrhosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Benedetta De Ponte Conti, Annarita Miluzio, Fabio Grassi, Sergio Abrignani, Stefano Biffo, Sara Ricciardi
Summary: The systematic analysis on translation rate of tumor-infiltrating lymphocytes (TILs) in humans and mice shows that high translation levels are associated with mTORC1 activation and low levels are correlated with hypoxia. CD8 translating cells exhibit a cytotoxic phenotype, while CD4 translating cells are mainly regulatory T cells with immunosuppressive functions.
Article
Medicine, General & Internal
Joanna Olkowska-Truchanowicz, Alicja Sztokfisz-Ignasiak, Aneta Zwierzchowska, Izabela Janiuk, Filip Dabrowski, Grazyna Korczak-Kowalska, Ewa Barcz, Katarzyna Bocian, Jacek Malejczyk
Summary: The study found that the proportions of regulatory T cells are increased in the peritoneal fluid of women with endometriosis compared to controls. Endometriosis is also associated with elevated concentrations of various cytokines and chemokines. Regulatory T cells in the peritoneal cavity of endometriosis patients may be attracted and activated by local chemokines and cytokines, especially CCL20 and TGF-beta.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biology
Severine Menoret, Laurent Tesson, Severine Remy, Victor Gourain, Celine Serazin, Claire Usal, Aude Guiffes, Vanessa Chenouard, Laure-Helene Ouisse, Malika Gantier, Jean-Marie Heslan, Cynthia Fourgeux, Jeremie Poschmann, Carole Guillonneau, Ignacio Anegon
Summary: In this study, a Foxp3-EGFP rat transgenic line was created to genetically tag CD4(+) and CD8(+) FOXP3(+) regulatory T cells. CD4(+)EGFP(+) Treg were found to be 5-10 times more frequent than CD8(+)EGFP(+) Treg. RNAseq analysis provided insights into the transcriptome of CD8(+) Treg, allowing for a better understanding of their phenotype and function.
Article
Environmental Sciences
Min-Kyung Cho, Jae-Gon Park, Hisato Iwata, Eun-Young Kim
Summary: Studies have revealed that exposure to TCDD resulted in severe weight loss and thymus atrophy in chicken embryos, indicating that TCDD affects the immune system of chicken embryos by suppressing T cell-mediated immune responses. Thymic transcriptome analysis suggested that TCDD-induced thymus atrophy may be associated with alterations in multiple signaling pathways, leading to significant changes in the expression levels of immune-related genes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, General & Internal
Dewi Masyithah Darlan, Delfitri Munir, Agung Putra, Nelva Karmila Jusuf
Summary: This study found that MSCs promote the generation of iTreg cells from human SLE PBMCs by releasing TGF beta 1, which helps control the SLE disease.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Review
Immunology
Ian Baudi, Keigo Kawashima, Masanori Isogawa
Summary: Hepatitis B virus (HBV) is a major cause of liver-related morbidity and mortality, with chronic hepatitis potentially progressing to cirrhosis and cancer. CD8+ T cells play a central role in clearing acute HBV infection, with weak CD8+ T cell responses in chronic hepatitis B (CHB) possibly due to multifaceted mechanisms and immunoregulatory cell populations in the liver. Studies suggest that genetic and epigenetic changes in dysfunctional CD8+ T cells may be targets for immunotherapy to treat CHB.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Vanesa Garrido-Rodriguez, Ines Herrero-Fernandez, Maria Jose Castro, Ana Castillo, Isaac Rosado-Sanchez, Maria Isabel Galva, Raquel Ramos, Israel Olivas-Martinez, Angel Bulnes-Ramos, Julio Canizares, Manuel Leal, Yolanda Maria Pacheco
Summary: The CD4/CD8 T-cell ratio is a useful marker for evaluating immune features in older individuals, showing differences in thymic output and immune profiles that can affect health status.
Article
Gastroenterology & Hepatology
Ilenia Pacella, Ilenia Cammarata, Carmela Martire, Giuseppina Brancaccio, Giovanni Battista Gaeta, Vincenzo Barnaba, Silvia Piconese
Summary: The study revealed that in patients with chronic HBV infection receiving NUC therapy and having advanced hepatic fibrosis, the frequency of AE-specific CD8(+) T cells was significantly increased. Different specificities of CD8(+) T cells were found to populate distinct subpopulations, suggesting a link between AE-specific T cells and advanced liver fibrosis.
LIVER INTERNATIONAL
(2021)