Article
Food Science & Technology
Caiyan Huang, Muawuz Ijaz, Li Chen, Can Xiang, Ce Liang, Xin Li, Christophe Blecker, Zhenyu Wang, Dequan Zhang
Summary: This study investigated the impact of chilling rate on the abundance of heat shock proteins (HSP), degradation of myofibrillar proteins, and caspase-3 activity in lamb muscle postmortem. The results showed that higher chilling rates led to increased levels of HSPs and myofibrillar fragmentation, and decreased degradation of myofibrillar proteins. Additionally, higher chilling rates inhibited caspase-3 activity.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Microbiology
Zhidong Zhang, Ryan Waters, Yanmin Li
Summary: Foot-and-mouth disease virus (FMDV) infection causes epithelial cell lesions and muscle-associated lesions in cloven-hoofed animals, leading to high mortality. Current knowledge about the non-epithelial tropism of FMDV remains limited.
VETERINARY MICROBIOLOGY
(2021)
Article
Plant Sciences
Tung-Yi Lin, Wei-Jyun Hua, Hsin Yeh, Ai-Jung Tseng
Summary: The study demonstrates that FIPs LZ-8 and GMI induce changes in the proteomic profile of tumor lesions in LLC1 cell-bearing mouse, potentially regulating heat shock proteins (HSPs)-related cell viability and inhibiting cell migration and inducing apoptosis. Inhibition of HSPs may contribute to the anti-lung cancer activity of FIPs.
Article
Immunology
Mahadappa Priyanka, H. B. Ranjitha, M. Karikalan, S. Chandramohan, Subhasmitha Behera, V. Gnanavel, Tamil Selvan Ramasamy Periyasamy, V. Umapathi, H. J. Dechamma, Narayanan Krishnaswamy
Summary: It was found that FMDV infection leads to overexpression of CAR in the myocardium of suckling mice, which may be the reason for their susceptibility to viral myocarditis.
MICROBIAL PATHOGENESIS
(2023)
Article
Environmental Sciences
Milton Talukder, Shao-Shuai Bi, Mei-Wei Lv, Jing Ge, Cong Zhang, Jin-Long Li
Summary: Cadmium exposure induces neuronal damage in the chicken brain, triggering the heat shock response (HSR) pathway and apoptotic pathway in response to the damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yun-Jung Hwang, Kyung-Kwan Lee, Jong-Won Kim, Kwang-Hyo Chung, Sang-Jick Kim, Wan-Soo Yun, Chang-Soo Lee
Summary: The study introduces an optical and electrochemical dual-modal approach for the specific detection of foot-and-mouth disease virus serotypes O and A, offering high sensitivity and accuracy.
Article
Immunology
W. A. Gayan Chathuranga, Chamith Hewawaduge, N. A. Nadeeka Nethmini, Tae-Hwan Kim, Ju Hun Kim, Young-Hoon Ahn, In-Joong Yoon, Sung-Sik Yoo, Jong-Hyeon Park, Jong-Soo Lee
Summary: This study developed two multiepitope recombinant proteins as potential vaccine candidates for foot-and-mouth disease. The results showed that these proteins effectively induced immune responses and protected animals from the virus. By using appropriate adjuvants, the protective efficacy of the vaccine candidates can be enhanced, providing a method for developing effective and safe vaccines for the prevention and control of foot-and-mouth disease.
Article
Veterinary Sciences
Yan Xiao, Suling Zhang, He Yan, Xiaolin Geng, Yanwei Wang, Xin Xu, Mengyue Wang, Haohao Zhang, Baicheng Huang, Wenqiang Pang, Ming Yang, Kegong Tian
Summary: The study successfully expressed capsid proteins of FMDV serotype O in Escherichia coli with an optimal tandem permutation (VP0-VP3-VP1), showing a protein yield close to 1:1:1. Immunization of pigs with FMDV VLPs induced FMDV-specific immune responses effectively and dose-dependently. The stable FMDV VLPs with multiple epitope exposure were effective for the induction of an immune response in pigs, laying a foundation for further development of the FMDV subunit vaccine.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Soyoon Ryoo, HyunJi Lee, Da-Rae Lim, Jung-Won Lee, Seng Bunnary, Sothyra Tum, Dong Sook Lee, Hyeonwoo Hwang, SomGyeol Jeong, JinJu Nah, Bok Kyung Ku, Jae-Myung Kim, Sang-Ho Cha
Summary: Foot-and-mouth disease (FMD) is endemic in Cambodia, with outbreaks caused by various serotypes of FMD virus (FMDV). Recent genetic analysis of FMDV in Cambodia revealed the presence of O/ME-SA/PanAsia, O/ME-SA/Ind-2001e, and A/ASIA/Sea-97 serotypes, with the first report of O/ME-SA/Ind-2001e infection in the country. Monitoring of new genotypes and serotypes is crucial for efficient control of FMD.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Katsuhiko Fukai, Kazuyuki Inoue, Akira Takeuchi, Makoto Yamakawa
Summary: Research shows that heat-denatured lysozyme may serve as a new disinfectant against FMDV, with variable effects on different types of FMDV.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Aaron T. Balana, Paul M. Levine, Timothy W. Craven, Somnath Mukherjee, Nichole J. Pedowitz, Stuart P. Moon, Terry T. Takahashi, Christian F. W. Becker, David Baker, Matthew R. Pratt
Summary: The study found that O-GlcNAc can activate the anti-amyloid activity of certain small heat shock proteins, inhibiting protein aggregation. Although O-GlcNAc levels are globally reduced in Alzheimer's disease brains, the modification of relevant small heat shock proteins is either maintained or increased, suggesting a mechanism to maintain these potentially protective O-GlcNAc modifications.
Article
Immunology
Nagendrakumar Balasubramanian Singanallur, Aldo Dekker, Phaedra Lydia Eble, Froukje van Hemert-Kluitenberg, Klaas Weerdmeester, Jacquelyn J. Horsington, Wilna Vosloo
Summary: Vaccination is a key tool in controlling and eradicating foot-and-mouth disease, but the effectiveness of vaccines against different virus strains needs to be considered. This study examined the protective effects of the O3039 vaccine strain against a new virus variant, showing promising results in terms of protection.
Article
Immunology
Sheeza Arshad, Sohail Raza, Rehan Rafique, Imran Altaf, Adeel Sattar
Summary: This study evaluated the effect of ivermectin on mice infected with FMDV. The results showed that ivermectin did not significantly reduce the viral load in the lungs and heart.
MICROBIAL PATHOGENESIS
(2023)
Article
Virology
Hu Dong, Yuanlu Lu, Yun Zhang, Suyu Mu, Nan Wang, Ping Du, Xiaoying Zhi, Xiaobo Wen, Xiangxi Wang, Shiqi Sun, Yanming Zhang, Huichen Guo
Summary: This study identified thermostable FMDV mutants by high-temperature screening, with an important alanine-to-threonine mutation at position 13 in the VP1 protein for capsid stability. These mutants showed improved stability and immunogenicity compared to the wild-type virus, potentially aiding in the development of a stable vaccine against FMDV serotype O.
JOURNAL OF VIROLOGY
(2021)
Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Infectious Diseases
Syed M. Jamal, Mohamad Hossein Nazem Shirazi, Fuat Ozyoruk, Unal Parlak, Preben Normann, Graham J. Belsham
TRANSBOUNDARY AND EMERGING DISEASES
(2020)
Article
Veterinary Sciences
Yonca B. Kabak, Mahmut Sozmen, Alparslan K. Devrim, Mert Sudagidan, Funda Yildirim, Tolga Guvenc, Murat Yarim, Yavuz M. Gulbahar, Ishtiaq Ahmed, Efe Karaca, Sinem Inal
ACTA VETERINARIA HUNGARICA
(2020)
Article
Biochemistry & Molecular Biology
Bahattin Avci, Caner Gunaydin, Tolga Guvenc, Canan Kulcu Yavuz, Nilufer Kuruca, S. Sirri Bilge
Summary: Oxidative stress is a mechanism in neurodegenerative diseases, and idebenone, an analog of Coenzyme Q10, has shown protective effects in a rotenone-induced Parkinson's disease model by inhibiting oxidative stress and increasing neuronal survival.
NEUROCHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Dilek Guvenc, Sinem Inal, Nilufer Kuruca, Sedat Gokmen, Tolga Guvenc
Summary: The study revealed the significant hepatotoxic effect of 3-PBA on HepG2 cells, inducing apoptosis through the regulation of Caspase-3 and Bcl-2. These findings are important for understanding the hepatotoxic mechanisms of 3-PBA.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Veterinary Sciences
Nilgun Gultiken, Murat Yarim, Gul Fatma Yarim, Mahmut Sozmen, Elvan Anadol, Murat Findik
Summary: The study investigated the plasma concentrations and expression of insulin-like growth factor-2 (IGF-2) in healthy dogs and those with cystic endometrial hyperplasia-pyometra complex. Results showed that IGF-2 plays an important role in the inflammatory process in bitches with CEH-pyometra complex. Plasma concentration of IGF-2 was positively correlated with its expression in the endometrial glands of Group 1.
ACTA VETERINARIA HUNGARICA
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ezgi Yuceer-Cetiner, Nilufer Ozkan, Mehmet Emin Onger, Mustafa Yavuz Gulbahar, Metehan Keskin
Summary: This study compared different graft materials for reconstructing mandibular bone defects, finding that a combination of autograft and xenograft was more effective than using either alone or leaving the defects empty. Immunohistochemical and stereological results support the adoption of the induced membrane technique in humans for small segmental mandibular defect reconstruction.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Anesthesiology
Ersin Koksal, Yasemin Burcu Ustun, Sezgin Bilgin, Abdurrahman Aksoy, Yavuz Kursad Das, Murat Yarim, Fatih Ozkan, Cengiz Kaya, Burhan Dost
Summary: This study evaluated the effects of dexketoprofen on a renal I/R model in rats. The results showed that dexketoprofen reduces I/R-induced systemic inflammation but increases renal tissue damage.
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2022)
Article
Andrology
Dilara Hologlu, Sezgin Gunes, Ramazan Asci, Ralf Henkel, Tolga Guvenc
Summary: The study found that chromatin condensation in sperm of infertile men was significantly lower than that of fertile men, and age, sperm concentration, morphology, and motility were significantly negatively correlated with chromatin condensation. However, no significant correlations were observed among chromatin condensation, SDF, and sperm DNA damage in terms of 8-OHdG concentration.
Article
Chemistry, Medicinal
Gul Fatma Yarim, Murat Yarim, Mahmut Sozmen, Ayris Gokceoglu, Ali Ertekin, Yonca Betil Kabak, Efe Karaca
Summary: This study investigated the potential preventive and therapeutic effects of nobiletin in an EAE mouse model, showing that nobiletin modulates the expressions of proinflammatory and antiinflammatory cytokines in the brain and spinal cord in a dose-dependent manner. These findings suggest that nobiletin has the ability to attenuate inflammation in EAE mouse model, but further clinical studies are needed to support these experimental results.
Article
Veterinary Sciences
Ismail Sahindokuyucu, Merve Biskin Turkmen, Tugce Sumer, Ahmed Eisa Elhag, Mehmet Eray Alcigir, Zafer Yazici, Gerald Barry, Mustafa Yavuz Gulbahar, Oguz Kul
Summary: This study reports a natural co-infection of Pigeon aviadenovirus A and Pigeon circovirus in a breeding pigeon flock in Central Anatolia, Turkey, with severe clinical signs.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Nilgun Gultiken, Murat Yarim, Selim Aslan, Hande Gurler, Gul Fatma Yarim, Muge Tuncay, Sinem Inal, Sabine Schafer-Somi
Summary: This study investigated the expression and regulation of AMH and AMHRII in the ovaries of female cats. The results showed that AMH is mainly expressed in granulosa cells of different level follicles and interstitial cells of corpora lutea, while AMHRII is closely co-localized with AMH and strongly expressed in the interstitial cells surrounding follicles undergoing atresia. Furthermore, it was found that serum AMH concentration is highest between day 30 and 50 of gestation, suggesting its association with ovarian activity and follicular atresia.
Article
Neurosciences
Gul Fatma Yarim, Filiz Kazak, Murat Yarim, Mahmut Sozmen, Bugra Genc, Ali Ertekin, Ayris Gokceoglu
Summary: This study indicates that apigenin could be used as a neuroprotective option to attenuate neuroinflammation in Parkinson's disease.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Pathology
Muhammed T. Kaya, Nilufer Kuruca, Mustafa Kanat, Fatma B. Akca, Mustafa Y. Gulbahar
Summary: This study investigated a 7-year-old Chinchilla queen and found multiple thin-walled cysts filled with transparent fluid in the uterus, greater omentum, and varicose ovarian veins. Histologically, the cysts varied in size and contained hypocellular collagen and a small number of vessels. The cyst walls and uterine serosa showed immunopositivity for cytokeratin and vimentin, indicating a mesothelial origin. Immunolabeling of alpha-smooth muscle actin was observed in the smooth muscle of many cysts.
JOURNAL OF COMPARATIVE PATHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Bahattin Avci, Caner Gunaydin, Mustafa Kulbay, Nilufer Kuruca, Tolga Guvenc, Suleyman Sirri Bilge
Summary: Sinapic acid may protect against rotenone-induced Parkinson's disease by regulating iron levels and inhibiting oxidative stress.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Virology
Emre Ozan, Bahadir Muftuoglu, Ismail Sahindokuyucu, Hanne Nur Kurucay, Sinem Inal, Nilufer Kuruca, Ahmed Eisa Elhag, Efe Karaca, Cuneyt Tamer, Semra Gumusova, Harun Albayrak, Gerald Barry, Mustafa Yavuz Gulbahar, Zafer Yazici
Summary: The study identified a virulent strain of Marek's disease virus circulating in Turkey, with the current national vaccination programme failing to stop its spread.
ARCHIVES OF VIROLOGY
(2021)
