Article
Pharmacology & Pharmacy
Woo-Yul Lee, Dong-Woo Chae, Choon-Ok Kim, Sang-Eun Lee, Yee-Gyung Kwak, Joon-Sup Yeom, Kyung-Soo Park
Summary: The study aimed to develop a population pharmacokinetic model of primaquine and its metabolite, and found that body weight and CYP2D6 activity significantly impact primaquine pharmacokinetics. The results showed that weight and enzyme activity play crucial roles in drug metabolism and can influence drug exposure levels.
Article
Microbiology
Christopher M. Rubino, Shawn Flanagan
Summary: A population pharmacokinetic model was developed to characterize the disposition of rezafungin in plasma following IV administration, showing significant relationships between subject descriptors and rezafungin PK parameters. The final model provided a precise and unbiased fit to observed concentrations and can reliably predict rezafungin PK in infected patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Junying Yuan, Bohao Zhang, Yiran Xu, Xiaoli Zhang, Juan Song, Wenhao Zhou, Kai Hu, Dengna Zhu, Lirong Zhang, Fengmin Shao, Shusheng Zhang, Junjie Ding, Changlian Zhu
Summary: This study investigated the pharmacokinetics of low-dose lithium carbonate in young children with intellectual disability. The results showed that the lithium PK properties in young children were similar to those in older children and adults, and the proposed model can be used to optimize the dosage regimen of lithium in children.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Dietmar Hamel, Alexandra Richard-Mazet, Florian Voisin, Inge Boehne, Florence Fraisse, Renate Rauh, Rose Huang, Michael Kellermann, Laura Letendre, Pascal Dumont, Steffen Rehbein
Summary: The pharmacokinetics of gamithromycin in swine showed favorable parameters following intramuscular injection, with an absolute bioavailability of 92.2% and dose proportionality. In clinical evaluation against swine respiratory disease, Zactran(R) demonstrated equivalent or better treatment success rates compared to Zuprevo(R).
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Oncology
Hon Lyn Tan, Guowei Kim, Christopher John Charles, Renee R. Li, Clarisse J. M. Jang, Asim Shabbir, Koy Min Chue, Chia Hui Tai, Raghav Sundar, Boon Cher Goh, Glenn Kunnath Bonney, Wen Donq Looi, Esther S. H. Cheow, Jimmy B. Y. So, Lingzhi Wang, Wei Peng Yong
Summary: The study evaluated the pharmacokinetics, peritoneal tissue drug concentration, penetration, and short-term safety of PIPAC using solvent-based paclitaxel in swine, showing linear pharmacokinetics and lower systemic exposure compared to IV administration. PIPAC paclitaxel demonstrated concentration at the peritoneal surface with estimated 2 mm penetration. Overall, PIPAC paclitaxel at 15mg/m(2) showed favorable toxicity profile, with dose-dependent neutropenia being the most significant adverse event.
Article
Agriculture, Multidisciplinary
Meiyu Zhang, Fangyu Zhang, Jingli Qiu, Xiaogui Shu, Tong Zhou, Sijia Liu, Yaxin Wang, Rong Liu, Xiantong Zheng, Limin He
Summary: This study systematically investigated the pharmacokinetics, tissue distribution, and residue depletion of praziquantel in swine. The findings have important implications for rational dosing strategies, reducing drug usage and side effects, accurately assessing the risks associated with praziquantel administration, and future use of the active enantiomer R-PZQ.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Sofie A. M. Brookhuis, Karel Allegaert, Lidwien M. Hanff, Marjolijn N. Lub-de Hooge, Andre Dallmann, Paola Mian
Summary: This review provides an overview of acetaminophen pharmacokinetics changes during pregnancy, showing an increase in distribution volume and clearance of acetaminophen in pregnant women compared to non-pregnant women. Gaps in knowledge, such as fetal and placental pharmacokinetic parameters, have been identified for further exploration before evidence-based dosing adjustments can be suggested.
Article
Microbiology
T. Nguyen, M. Oualha, C. Briand, M. Bendavid, A. Beranger, S. Benaboud, J-M Treluyer, Y. Zheng, F. Foissac, S. Winter, I Gana, S. Boujaafar, V Lopez, R. Berthaud, Z. Demir, N. Bouazza, D. Hirt
Summary: This study characterized ganciclovir pharmacokinetics in children and optimized dosing schemes for curative or preventive treatment of CMV infections. Dosing recommendations were provided based on body weight and estimated glomerular filtration rate, and individualized therapeutic drug monitoring was suggested for dose refinement.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Veterinary Sciences
Tomasz Grabowski, Artur Burmanczuk, Rafal Derlacz, Tadeusz Stefaniak, Anna Rzasa, Jacek Borkowski
Summary: The study evaluated the impact of different administration sites on the pharmacokinetics of ustekinumab in pigs. Although there were no significant differences in absorption rates, significant variations were observed in parameters such as time of maximal concentration and relative bioavailability between internal and external injections.The results suggest that the bioavailability and pharmacokinetic profiles of subcutaneously administered ustekinumab can be influenced by the injection site in pigs.
JOURNAL OF VETERINARY SCIENCE
(2021)
Article
Microbiology
Aaron J. Heffernan, Fekade B. Sime, Nilesh Kumta, Steven C. Wallis, Brett McWhinney, Jacobus Ungerer, Gloria Wong, Gavin M. Joynt, Jeffrey Lipman, Jason A. Roberts
Summary: This study aimed to describe the pharmacokinetics of ceftriaxone in critically ill adult patients and determine the best dosing regimens. It found that the dose should be adjusted based on the patient's renal function, albumin concentration, and isolate MIC.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
A. Laura Nijstad, Wan-Yu Chu, Evelien De Vos-Kerkhof, Catherine F. Enters-Weijnen, Mirjam E. van de Velde, Gertjan J. L. Kaspers, Shelby Barnett, Gareth J. Veal, Arief Lalmohamed, C. Michel Zwaan, Alwin D. R. Huitema
Summary: This study investigated the pharmacokinetics of vincristine, a chemotherapeutic agent, in different age groups and found that the binding capacity of vincristine to beta-tubulin decreases with increasing age, suggesting that young children can tolerate higher doses of the drug.
PHARMACEUTICAL RESEARCH
(2022)
Article
Veterinary Sciences
Victor Neira, Cristian Melgarejo, Constanza Urzua-Encina, Felipe Berrios, Valentina Valdes, Sunil Mor, Barbara Brito-Rodriguez, Galia Andrea Ramirez-Toloza
Summary: This study identified and characterized RVA in swine farms in Chile, revealing a high prevalence and genetic evolution of the virus. The results highlight the potential zoonotic nature of RVA circulating in Chilean swine farms.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Microbiology
E. Leegwater, D. J. A. R. Moes, L. B. E. Bosma, T. H. Ottens, I. M. van der Meer, C. van Nieuwkoop, E. B. Wilms
Summary: This study aimed to investigate the pharmacokinetics of remdesivir and GS-441524 in hospitalized COVID-19 patients. The clearance of GS-441524 was found to be dependent on the eGFR, with high interindividual variability. The short elimination half-life of remdesivir in COVID-19 patients and the accumulation of GS-441524 in patients with reduced renal function were observed. Alternative dosing regimens may improve the effectiveness of remdesivir treatment in COVID-19 patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Clinical Neurology
Xin Liu, Gehang Ju, Xinyi Huang, Wenyu Yang, Lulu Chen, Chao Li, Qingfeng He, Nuo Xu, Xiao Zhu, Dongsheng Ouyang
Summary: This study aimed to develop a popPK model characterizing the disposition of SCIT in the Chinese population and proposed remedial strategies for non-adherence scenarios. Significant covariates impacting SCIT exposure were identified, and recommendations for dosage adjustments in different scenarios were provided based on CYP2C19 phenotypes. The study highlighted the importance of personalized medication based on patient characteristics and the utilization of popPK repository for precision dosing.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Pharmacology & Pharmacy
Bing Chen, Hao-Qiang Shi, Meihua Rose Feng, Xi-Han Wang, Xiao-Mei Cao, Wei-Min Cai
Summary: This study established a population pharmacokinetic model for INH and AcINH in Chinese population, evaluating the impact of NAT2 genotype on drug transformation and metabolism, which may be beneficial for individualized therapy.
FRONTIERS IN PHARMACOLOGY
(2022)