Article
Veterinary Sciences
Yuxin Yang, Jingyuan Kong, Yu Liu, Qinyao Wu, Yuying Cao, Jicheng Qiu, Lu Zhang, Xiaohui Gong, Fuhua Zhao, Xingyuan Cao, Jianzhong Wang
Summary: This study investigated the pharmacokinetic profiles and bioequivalence of two cyclosporine oral solutions in cats. The results showed no significant differences in major pharmacokinetic parameters between the two formulations and the blood profiles of cyclosporine were similar after administration.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Agriculture, Dairy & Animal Science
Federica Di Cesare, Viviana Negro, Giuliano Ravasio, Roberto Villa, Susanna Draghi, Petra Cagnardi
Summary: Gabapentin is an anticonvulsant drug that effectively controls neuropathic pain in humans. It is also used in veterinary medicine to control seizures and manage pain and anxiety. This review discusses the use and pharmacokinetic aspects of gabapentin in dogs, cats, and horses, highlighting its therapeutic potential for neuropathic diseases and analgesia. However, more trials and pharmacokinetic studies are needed to determine the optimal dosage and use of gabapentin in veterinary medicine.
Article
Veterinary Sciences
M. Schneider, F. Dron, E. Cuinet, F. Woehrle
Summary: Cats have lower clearance rates and longer terminal half-lives for Cimicoxib compared to dogs, with a reduced ability to produce metabolites of the drug. Quinidine, a specific CYP2D6 inhibitor, was found to be more potent in feline microsomes, indicating a lower affinity of Cimicoxib to the enzyme in cats.
VETERINARY JOURNAL
(2021)
Article
Veterinary Sciences
Rodney R. Walters, Joseph F. Boucher, Flavia De Toni
Summary: Frunevetmab shows promise in providing pain relief for cats with joint diseases, with favorable pharmacokinetics and low immunogenicity. The drug demonstrated good bioavailability and a long half-life, leading to sustained levels in the plasma. Additionally, the low incidence of immunogenicity highlights the safety profile of frunevetmab in feline patients.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Pharmacology & Pharmacy
J. Lakritz, T. K. Aarnes, B. Alva, J. Howard, G. Magnin, P. Lerche, B. Kukanich
Summary: This prospective experimental study evaluated the pharmacokinetics of tapentadol hydrochloride orally administered to cats. Blood samples were collected at various time points after drug administration and analyzed using ultra-performance liquid chromatography-tandem mass spectrometry. The results showed that tapentadol-O-sulfate was the predominant metabolite, and further studies are needed to assess the analgesic effect of tapentadol in relation to its plasma concentrations.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Agriculture, Dairy & Animal Science
Lilia Gutierrez, Graciela Tapia, Eduardo Gutierrez, Hector Sumano
Summary: The trial presents a new pharmaceutical preparation, DABE, that improves the oral bioavailability of enrofloxacin in cats while reducing adverse reactions. Pharmacokinetic (PK) study revealed that DABEs administered by concealing them in the cat's food achieves adequate drug concentration in cats without causing discomfort, unlike other oral formulations. No rejection of medicated food was observed among the cats in the study.
Article
Pharmacology & Pharmacy
Marta Garbin, Javier Benito, Helene L. M. Ruel, Ryota Watanabe, Beatriz P. Monteiro, Petra Cagnardi, Paulo Steagall
Summary: This study described the pharmacokinetics of two doses of bupivacaine administered via ultrasound-guided TAP block in cats. The results showed that both doses of bupivacaine produced concentrations below toxic levels in cats.
Article
Biochemistry & Molecular Biology
Yan Li, Ziqian Liu, Xin Wan, Lingying Xie, Hui Chen, Guo Qu, Han Zhang, Yue-Fei Zhang, Shicheng Zhao
Summary: In this study, xanthan gum-based composites were successfully graft-modified by amantadine (XG-Fe3+/AM) to enhance the adsorption capacity and selectivity for methylene blue (MB) from aqueous solutions. The adsorption equilibrium of MB was achieved within 5 minutes at an initial concentration of 100 mg/L, with a maximum adsorption capacity of 565 mg/g. XG-Fe3+/AM showed a high removal rate of 95% for MB even after 5 desorption-regeneration cycles. The adsorption performance of MB was systematically examined by pH, contact time, temperature, and initial dye concentration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Danuta Krasowska, Agnieszka Gerkowicz, Paula Wroblewska-Luczka, Aneta Grabarska, Katarzyna Zaluska-Ogryzek, Dorota Krasowska, Jarogniew J. Luszczki
Summary: Amantadine has anti-melanoma properties and can alleviate symptoms of Parkinson's disease. Amantadine combined with CDDP showed additive interaction in some melanoma cell lines, while its combination with MTO exhibited synergistic interaction in one cell line.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Inara Fernanda Misiuta Raupp-Barcaro, Isabella Caroline da Silva Dias, Erika Meyer, Jeane Cristina Fonseca Vieira, Giovana da Silva Pereira, Arthur Ribeiro Petkowicz, Rubia Maria Weffort de Oliveira, Roberto Andreatini
Summary: The antidepressant-like effects of amantadine in mice may be mediated by its actions on D2 and NMDA receptors, likely involving hippocampal neurogenesis.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Veterinary Sciences
Shiting Xie, Yixing Lu, Jun Wang, Changcheng Lin, Peiyu Ye, Xiaolin Liu, Wenguang Xiong, Zhenling Zeng, Dongping Zeng
Summary: A selective and sensitive LC-MS/MS method was developed and validated for the simultaneous quantification of MBO, PZQ, C-4-OH-PZQ, and T-4-OH-PZQ in cat plasma. The method showed good precision, accuracy, recovery, and linearity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Immunology
Nuha Milad Ashtiwi, Demba Sarr, Tamas Nagy, Z. Beau Reneer, Ralph A. Tripp, Balazs Rada
Summary: The combination treatment of OSCN- and AMT shows potential in curing lethal influenza virus infection. Monotherapy with OSCN- or AMT alone does not substantially improve survival outcomes, but the combination treatment significantly inhibits viral replication.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Parasitology
Virginie Jacquot, Prescillia Buellet, Laura Letendre, Wei Tong, Henry Li, Eric Tielemans
Summary: Esafoxolaner, eprinomectin, and praziquantel in NexGard((R)) Combo showed effective parasiticidal properties in cats, with rapid onset, sustained efficacy, and no relevant interference observed. Dose proportionality was demonstrated and steady state was reached after repeated monthly administrations with limited accumulation and safe drug plasma concentrations.
Article
Pharmacology & Pharmacy
Bruno H. Pypendop, Yael Shilo-Benjamini
Summary: This study characterized the pharmacokinetics of butorphanol in cats under isoflurane anesthesia, showing that a three-compartment model best fit the data. Pharmacokinetic simulation suggested that a specific dosing regimen could rapidly achieve and maintain stable plasma concentrations for up to 6.5 hours.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Infectious Diseases
Daniel Chober, Zenon Czajkowski, Bogusz Aksak-Was, Katarzyna Dalewska-Kucharczyk, Katarzyna Holubczak, Sylwia Karasinska-Milchert, Mateusz Jaremko, Milosz Skowron, Malwina Karasinska-Cieslak, Milosz Parczewski
Summary: In patients with severe respiratory failure treated in the ICU, the use of amantadine is associated with lower mortality, which may be attributed to its potential anti-inflammatory and immunomodulatory effects.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Veterinary Sciences
Jodie Daglish, Sarah S. le Jeune, Bruno H. Pypendop, Esther Millares Ramirez, Tracy A. Turner
JOURNAL OF EQUINE VETERINARY SCIENCE
(2017)
Article
Veterinary Sciences
Thaleia-Rengina Stathopoulou, Maria Kouki, Bruno H. Pypendop, Atholl Johnston, Serafeim Papadimitriou, Ludovic Pelligand
JOURNAL OF FELINE MEDICINE AND SURGERY
(2018)
Editorial Material
Veterinary Sciences
Scott A. Katzman, Marcos Perez-Noguez, Bruno H. Pypendop, Charles E. Alex, Verena K. Affolter
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2018)
Article
Veterinary Sciences
Bruno H. Pypendop, M. G. Ranasinghe, Kirby Pasloske
VETERINARY ANAESTHESIA AND ANALGESIA
(2018)
Article
Veterinary Sciences
Bruno H. Pypendop, Kristine T. Siao, M. G. Ranasinghe, Kirby Pasloske
VETERINARY ANAESTHESIA AND ANALGESIA
(2018)
Article
Veterinary Sciences
Bruno H. Pypendop, M. G. Ranasinghe, Kirby Pasloske
VETERINARY ANAESTHESIA AND ANALGESIA
(2018)
Article
Veterinary Sciences
Alonso G. P. Guedes, Julie M. Meadows, Bruno H. Pypendop, Eric G. Johnson, Bianca Zaffarano
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2018)
Article
Veterinary Sciences
Katherine J. Bennett, Reza Seddighi, Kaitlin A. Moorhead, Kristin Messenger, Sherry K. Cox, Xiaocun Sun, Kirby Pasloske, Bruno H. Pypendop, Thomas J. Doherty
VETERINARY ANAESTHESIA AND ANALGESIA
(2019)
Article
Veterinary Sciences
Elizabeth V. Acutt, Sarah S. le Jeune, Bruno H. Pypendop
JOURNAL OF EQUINE VETERINARY SCIENCE
(2019)
Article
Pharmacology & Pharmacy
Bruno H. Pypendop, Hanna Ahokoivu, Juhana Honkavaara
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Pharmacology & Pharmacy
Robert J. Brosnan, Bruno H. Pypendop, Scott D. Stanley
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2020)
Article
Pharmacology & Pharmacy
Chiara E. Hampton, Patricia Queiroz-Williams, Montana J. Oubre, Anna Martin, Andrea T. Gisclair, Bruno H. Pypendop
Summary: This study aimed to determine the pharmacokinetics of oral and compounded intravenous gabapentin in healthy adult Duroc pigs. The results showed that a two-compartment model best fitted the data following IV administration, and the estimated oral bioavailability was 47%. Additionally, short-lived sedation was observed after IV administration, and simulation based on the study suggested appropriate oral dosing regimens for achieving and maintaining desired plasma concentrations in pigs.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Bruno H. Pypendop, Yael Shilo-Benjamini
Summary: This study characterized the pharmacokinetics of butorphanol in cats under isoflurane anesthesia, showing that a three-compartment model best fit the data. Pharmacokinetic simulation suggested that a specific dosing regimen could rapidly achieve and maintain stable plasma concentrations for up to 6.5 hours.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Veterinary Sciences
Peter J. Pascoe, Bruno H. Pypendop, Juan C. Pavez Phillips, Heather K. DiMaio Knych, David Sanchez-Migallon Guzman, Michelle G. Hawkins
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2018)
Article
Veterinary Sciences
Alonso G. P. Guedes, Julie M. Meadows, Bruno H. Pypendop, Eric G. Johnson
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2018)