期刊
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
卷 35, 期 4, 页码 397-401出版社
WILEY
DOI: 10.1111/j.1365-2885.2011.01337.x
关键词
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资金
- Nanjing Agricultural University [KJ070128]
- Key Laboratory of Genetic Breeding and Aquatic Animals and Aquaculture Biology of the Ministry of Agriculture [BZ2007-04]
Fang, X., Liu, X., Liu, W., Lu, C. Pharmacokinetics of enrofloxacin in allogynogenetic silver crucian carp, Carassius auratus gibelio. J. vet. Pharmacol. Therap. 35, 397-401. The pharmacokinetics of enrofloxacin (EF) was investigated after single intravenous (i.v.) and oral (p.o.) administration of 10 mg/kg body weight (b.w.) in 300 healthy allogynogenetic silver crucian carp at 2426 degrees C. The plasma concentrations of EF and its metabolite ciprofloxacin (CF) were determined by high-performance liquid chromatography. After i.v. administration, the plasma concentrationtime data were described by an open two-compartment model. The elimination half-life (T1/2 beta), area under the concentrationtime curve (AUC) and total body clearance of EF were 63.5 h, 239.6 mu g center dot h/mL and 0.04 L/h/kg, respectively. Following p.o. administration, the plasma concentrationtime data showed a double peakshaped curve, indicating the possibility of enterohepatic recirculation of EF in allogynogenetic silver crucian carp. The maximum plasma concentration (Cmax), T1/2 beta and AUC of EF were 4.5 mu g/mL, 62.7 h and 205.9 mu g center dot h/mL, respectively. Absorption of EF was very good with a bioavailability (F) of 86%, which could be correlated with the unique structure of the alimentary canal in allogynogenetic silver crucian. CF, an active metabolite of EF, was not detected in this study.
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