Article
Infectious Diseases
Richard J. Everts, Sharon J. Gardiner, Mei Zhang, Ronald Begg, Stephen T. Chambers, John Turnidge, Evan J. Begg
Summary: This study evaluated the effects of probenecid on the pharmacokinetics and pharmacodynamics of oral cephalexin in healthy volunteers. Results showed that probenecid increased cephalexin plasma concentrations and prolonged half-life, enhancing the likelihood of reaching PK/PD targets. Co-administration of probenecid may expand the clinical benefits of oral cephalexin.
JOURNAL OF INFECTION
(2021)
Article
Chemistry, Medicinal
Pureum Kang, Chang-Keun Cho, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee, Chang-Ik Choi, Jung-Woo Bae
Summary: The study investigated the effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide. The results showed that CYP2C9 and CYP2C19 genetic polymorphisms significantly affected the pharmacokinetics of gliclazide. However, the effects on plasma glucose and insulin responses were not significant, suggesting further research is needed.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Ki Young Huh, Jun Gi Hwang, Wonjung Shin, Seungjae Baek, JaeDuk Choi, Nora Lee, Young Min Cho, Howard Lee
Summary: HM15136, a novel long-acting glucagon analogue, was shown to be safe and well tolerated in doses ranging from 10-120 μg/kg in a randomized, double-blind, placebo-controlled study. It increased blood glucose levels and suppressed the secretion of endogenous glucagon.
DIABETES OBESITY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Ana Alarcia-Lacalle, Helena Barrasa, Javier Maynar, Andres Canut-Blasco, Carmen Gomez-Gonzalez, Maria Angeles Solinis, Arantxazu Isla, Alicia Rodriguez-Gascon
Summary: This study developed a rapid, simple and reproducible HPLC-UV method for quantifying ceftaroline in plasma samples, which was accurate and stable, successfully applied in two critically ill patients.
Article
Chemistry, Medicinal
Nam-Tae Kim, Chang-Keun Cho, Pureum Kang, Hye-Jung Park, Yun Jeong Lee, Jung-Woo Bae, Choon-Gon Jang, Seok-Yong Lee
Summary: The CYP2C9*3 and *13 alleles significantly affect the pharmacokinetics of glipizide, resulting in elevated plasma concentrations of the drug. Individuals with the CYP2C9*3 and *13 genotypes show a significant increase in mean AUC(0-infinity) of glipizide compared to those with the wild-type CYP2C9*1/*1 genotype, while the effects of glipizide on plasma glucose and insulin levels are not significantly different among CYP2C9 genotype groups.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Infectious Diseases
Yaxin Fan, Yi Li, Yuancheng Chen, Jicheng Yu, Xiaofen Liu, Wanzhen Li, Beining Guo, Xin Li, Jingjing Wang, Hailan Wu, Yu Wang, Jiali Hu, Yan Guo, Fupin Hu, Xiaoyong Xu, Guoying Cao, Jufang Wu, Yingyuan Zhang, Jing Zhang, Xiaojie Wu
Summary: This study evaluated the pharmacokinetic/pharmacodynamic profiles and safety of CMS in Chinese subjects following a recommended dosage. The results showed that CMS may be effective against most carbapenem-resistant organisms, but inadequate for some carbapenem-resistant Acinetobacter baumannii.
Article
Endocrinology & Metabolism
Qi Pan, Xiaoxia Wang, Wenjia Li, Xiaofeng Chen, Yulei Zhuang, Qinghong Zhou, Yuhui Huang, Yijie Zhou, Li Lan, Zhijie Wang, Wenjia Wang, Juan Hong, Wei-Hua Hao, Yu-Tsai Yang, Lixin Guo
Summary: This study aimed to verify whether the oral insulin N11005 is used as a prandial insulin by comparing its pharmacokinetics (PK), pharmacodynamics (PD), and safety profiles with a short-acting biosynthetic human insulin (Novolin R). A total of 12 healthy Chinese male subjects were enrolled in the study, and the results showed that N11005 has similar PD characteristics to prandial insulins, with a faster onset of action and comparable duration of action to the reference insulin. The study also demonstrated the safety and tolerability of N11005.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Banaz Abbas, Nagwa A. Sabri, Amal A. El-Khouly
Summary: The study aimed to investigate the effects of food and selected single nucleotide polymorphisms in the UGT2B7 gene on the pharmacokinetics and pharmacodynamics behavior of indapamide. The results showed that food had a modest impact on the maximum concentration and absorption time of indapamide, while genetic variations in the UGT2B7 gene had no significant impact on the pharmacokinetic parameters. It was concluded that food had a moderate effect on the pharmacokinetics, but there were no significant differences in safety and efficacy.
Article
Pharmacology & Pharmacy
Hanjing Chen, Weili Chen, Fei Yuan, Qingcheng Guo, Xunmin Zhang, Chenguang Wang, Xuening Li
Summary: This study evaluated the bioequivalence of CMAB807, a biosimilar to denosumab, for the treatment of osteoporosis. The results showed that CMAB807 had similar pharmacokinetics, pharmacodynamics, safety, and immunogenicity to denosumab. CMAB807 could potentially be a new treatment option for patients with osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yijing Liao, Anran Ma, Zhihong Wang, Yue Zhou, Lin Liu, Na Zhang, Li Zhang, Gerald J. Prud'homme, Qinghua Wang
Summary: This study demonstrated that supaglutide has linear pharmacokinetic characteristics and can produce prolonged hypoglycemic effects, suggesting its potential as a weekly dosing therapeutic agent for the treatment of type 2 diabetes and metabolic diseases.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xue Zhao, Hongzhong Liu, Wei Tian, Ligang Fang, Mengyang Yu, Xiaofei Wu, Aijing Liu, Ruijie Wan, Li Li, Jinghui Luo, Yuqiong Li, Bo Liu, Yu He, Xiaowen Chen, Yuan Li, Donghong Xu, Hongyun Wang, Xiaohong Han
Summary: This study aimed to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of aficamten in healthy Chinese adults. The results showed that aficamten was safe and well-tolerated in the Chinese population, with pharmacokinetics comparable to Western participants. These findings support future clinical studies of aficamten in Chinese patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Suping Niu, Min Chen, Diqin Yan, Xiangxing Liu, Shuren Guo, Lun Ou, Huaying Fan, Jie Lv, Qian Wang, Wenliang Dong, Lin Xia, Simin Wang, Gang Liu, Qun Gu, Danjie Guo, Hongxia Liu, Huiying Rao, Qingshan Zheng, Xiaoyan Nie, Haifeng Song, Yi Fang
Summary: This study aimed to explore the safety and efficacy of LY06006 when administered subcutaneously in healthy Chinese adults. The results showed that single-dose subcutaneous administration of LY06006 was safe and well-tolerated in this population, and exhibited linear pharmacokinetic characteristics.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Veterinary Sciences
Poonavit Pichayapaiboon, Lalida Tantisuwat, Pakit Boonpala, Nakkawee Saengklub, Tussapon Boonyarattanasoonthorn, Phisit Khemawoot, Anusak Kijtawornrat
Summary: The study showed that intravenous pimobendan at the recommended dose for dogs can effectively increase cardiac contraction and output, accelerate cardiac relaxation, and decrease vascular resistance. These findings support the use of injectable pimobendan in the treatment of acute heart failure.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Chemistry, Medicinal
Inseung Jeon, Jaeseong Oh, Yu-Kyung Kwon, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee
Summary: The study compared the pharmacokinetic (PK), pharmacodynamic (PD), and tolerability profiles of CKD-11101 with those of the reference drug in healthy subjects. Results showed that CKD-11101 was well tolerated and exhibited comparable PK and PD characteristics with the reference drug after a single intravenous (IV) or subcutaneous (SC) dose.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Medicine, Research & Experimental
Deok Y. Yoon, Jung Sunwoo, Naree Shin, Ah R. Kim, Bongtae Kim, Geun S. Song, In-Jin Jang, SeungHwan Lee
Summary: The study assessed the impact of meal timing on the pharmacokinetics and pharmacodynamics of tegoprazan 50 mg, finding that meal timing had no clinically significant effect on the drug.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Steven G. Friedenberg, Katharine F. Lunn, Kathryn M. Meurs
Article
Veterinary Sciences
Tiffany L. Wormhoudt, Mary-Keara Boss, Katharine Lunn, Lynn Griffin, Del Leary, Kristy Dowers, Sangeeta Rao, Susan M. LaRue
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2018)
Article
Veterinary Sciences
Whitney M. Young, Annie Oh, Jonathan G. Williams, Melanie L. Foster, William W. Miller, Katharine F. Lunn, Freya M. Mowat
VETERINARY OPHTHALMOLOGY
(2018)
Article
Multidisciplinary Sciences
Kathleen M. Aicher, John M. Cullen, Gabriela S. Seiler, Katharine F. Lunn, Kyle G. Mathews, Jody L. Gookin
Article
Veterinary Sciences
Annie Oh, Melanie L. Foster, Jonathan G. Williams, Chaowen Zheng, Hongyu Ru, Katharine F. Lunn, Freya M. Mowat
VETERINARY OPHTHALMOLOGY
(2019)
Article
Veterinary Sciences
Annie Oh, Melanie L. Foster, Katharine F. Lunn, Freya M. Mowat
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2019)
Article
Veterinary Sciences
Adam J. Birkenheuer, Kenneth D. Royal, Anthony Cerreta, Daniel Hemstreet, Katharine F. Lunn, Jody L. Gookin, Stephanie McGarvey
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2020)
Article
Veterinary Sciences
Kathryn A. LaQuaglia, James B. Robertson, Katharine F. Lunn
Summary: In dogs receiving vincristine for immune-mediated thrombocytopenia, administration of cyclosporine was significantly associated with the development of neutropenia. Neutropenic dogs had a significantly longer duration of hospitalization compared to non-neutropenic dogs, but there was no difference in survival rate.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Nanelle R. Barash, Erin Lashnits, Zachary T. Kern, Mary Katherine Tolbert, Katharine F. Lunn
Summary: This study describes the management and outcomes of dogs with esophageal or gastric bone foreign bodies. It found that dogs with esophageal foreign bodies were younger and had a larger bone cross-sectional area relative to body weight. Most gastric bone foreign bodies were left in place and dissolved without complications.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
Keira Sztukowski, Taylor Gin, Jennifer Neel, Katharine Lunn
Summary: This case report presents a 14-year-old castrated Pomeranian diagnosed with primary hyperparathyroidism and multiple myeloma, conditions rarely reported concurrently in veterinary literature. It emphasizes the importance of thoroughly investigating multiple issues when they cannot be explained by a single diagnosis.
VETERINARY RECORD CASE REPORTS
(2021)
Article
Veterinary Sciences
Jessica M. Quimby, Shannon M. McLeland, Rachel E. Cianciolo, Katharine F. Lunn, Jody P. Lulich, Andrea Erikson, Lara B. Barron
Summary: In cats without kidney disease, older cats have more glomerulosclerosis, tubular atrophy, and inflammation in the kidneys compared to younger cats, and these histopathologic lesions are weakly positively correlated with age.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2022)
Article
Veterinary Sciences
Rene E. Paschall, Jessica M. Quimby, Rachel E. Cianciolo, Shannon M. McLeland, Katharine F. Lunn, Jonathan Elliott
Summary: This study investigated capillary rarefaction in the kidneys of cats with chronic kidney disease (CKD) and found that capillary number and area were significantly decreased in CKD cats, and correlated with renal dysfunction and histopathologic lesions.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Alex M. M. Lynch, Laura K. K. Ruterbories, James B. B. Robertson, Katharine F. F. Lunn, Freya M. M. Mowat
Summary: This study investigated the hemostatic profiles of dogs with sudden acquired retinal degeneration syndrome (SARDS) and found that dogs with SARDS exhibited a hypercoagulable state. However, the role of hypercoagulability in the pathogenesis of SARDS remains to be determined.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
A. S. Berg, M. E. Jacob, L. B. Mamo, D. H. Pluta, K. F. Lunn
Summary: Sterility in refrigerated multi-dose insulin vials was evaluated over a 6-month period. The study found that multi-dose insulin products containing phenol and metacresol pose minimal risk of infection, even without alcohol swab preparation.
JOURNAL OF SMALL ANIMAL PRACTICE
(2023)
Article
Veterinary Sciences
Jessica Quimby, Andrea Erickson, Shannon Mcleland, Rachel Cianciolo, David Maranon, Katharine Lunn, Jonathan Elliott, Jack Lawson, Ann Hess, Rene Paschall, Susan Bailey
Summary: This study found significantly increased renal cell senescence, telomere shortening, and nitrosative stress in cats with CKD, suggesting that these patients may benefit from senolytic therapy.
VETERINARY SCIENCES
(2021)