Review
Pharmacology & Pharmacy
Nicolaj Mikkelsen, Per Damkier, Sidsel Arnspang Pedersen
Summary: This review provides a clinical overview of serotonin syndrome, covering its pathophysiology, epidemiology, clinical manifestations, diagnostic criteria, differential diagnosis and treatment, as well as classifying serotonergic drugs and their mechanism of action. The emphasis is on the pharmacological context, as it is crucial for the detection and management of serotonin syndrome.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jamie L. Archambault, Cassidy A. Delaney
Summary: This article discusses the impact of 5-HT on fetal and neonatal pulmonary circulation and summarizes the existing preclinical and clinical literature on 5-HT in neonatal PH.
Review
Pharmacology & Pharmacy
Carolina Ramos Mendonca, Raul Manhaes-de-Castro, Barbara Juacy Rodrigues Costa de Santana, Luana Olegario da Silva, Ana Elisa Toscano, Omar Guzman-Quevedo, Ligia Cristina Monteiro Galindo
Summary: This systematic review investigated the effects of flavonols on the serotonergic system. The results showed that flavonols can modify physiological aspects of the system, increasing serotonin levels, decreasing its metabolite levels, and promoting antioxidant effects. Additionally, flavonols were found to modulate the serotonergic system, associated with antidepressant and anxiolytic activities.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Toxicology
Sanjay Prakash, Chaturbhuj Rathore, Kaushik Rana, Anurag Prakash
Summary: Serotonin syndrome (SS) is a potentially life-threatening clinical condition caused by drug-induced effects. This systematic review aimed to characterize the epidemiological profile, clinical features, and risk factors associated with fatal SS. The study found that fatal SS is rare but commonly presents with hyperthermia, seizures, and elevated CK activities. The use of cyproheptadine appears to be infrequent for these patients.
CLINICAL TOXICOLOGY
(2021)
Review
Clinical Neurology
Sanjay Prakash, Chaturbhuj Rathore, Kaushik Rana, Harsh Patel
Summary: Serotonin syndrome (SS) is a potentially fatal clinical syndrome caused by drugs with serotonergic properties. This study reviewed literature on SS in patients receiving antiepileptic drugs (AEDs), suggesting that AEDs with serotonergic properties may induce SS, especially when used with other serotonergic agents. Most cases included in the study were published in the last 10 years, with the majority of patients exposed to multiple serotonergic drugs simultaneously.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Review
Pharmacology & Pharmacy
Fawzy Elbarbry, Nicholas Moshirian
Summary: This systematic review evaluates the evidence linking linezolid to serotonin toxicity when used alone or in combination with other serotonergic agents. The results show a low incidence of serotonin toxicity both in linezolid monotherapy and combination therapy, and symptom resolution is achieved in most cases after discontinuation of linezolid and serotonergic agents.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Cell Biology
Stefania Della Vecchia, Maria Marchese, Filippo Maria Santorelli, Federico Sicca
Summary: Serotonergic dysfunction is believed to be a major cause of depression, although other dysfunctional mechanisms may also be involved. The astrocytic inward rectifier potassium channel 4.1 (Kir4.1) may play an important role in neuronal excitability and glutamate metabolism, with its dysfunction potentially related to depression.
Review
Chemistry, Analytical
Dorin Dascalescu, Constantin Apetrei
Summary: This review discusses the recent progress made in the field of electrochemical detection of serotonin using electrochemical sensors based on various nanomaterials, which have excellent analytical performances and practical applications.
Review
Biochemistry & Molecular Biology
Mariana Lapo Pais, Joao Martins, Miguel Castelo-Branco, Joana Goncalves
Summary: Tryptophan is an essential amino acid that plays a role in neuropsychiatric diseases. Women have a higher susceptibility to serotonin alterations due to changes in tryptophan levels, leading to a female sex bias in neuropsychiatric diseases. Further research is needed on the impact of diet and sex steroids on tryptophan metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yaeko Hashimoto, Takuji Suzuki, Kenji Hashimoto
Summary: The ongoing COVID-19 pandemic has sparked interest in drug repurposing, particularly in the use of antidepressants. Clinical data suggest that early-stage COVID-19 patients who take antidepressants may have a lower risk of intubation or death. Fluvoxamine, among antidepressants, is the most attractive drug for mild to moderate COVID-19 cases. Additionally, there may be a possible link between maternal COVID-19 infection and a risk for neuropsychiatric disorders in offspring, such as autism spectrum disorder and schizophrenia.
MOLECULAR PSYCHIATRY
(2022)
Review
Clinical Neurology
Smi Choi-Kwon, Jong S. Kim
Summary: Post-stroke mood and emotional disturbances, including post-stroke anger (PSA), are frequent and diverse in their manifestations. PSA can be as frequent as post-stroke depression and can range from overt aggressive behaviors to becoming irritable and hostile. The possible mechanisms of PSA include neurochemical dysfunction, frustration, and genetic predisposition. PSA causes distress and negatively impacts the patient's quality of life and their caregivers. It can be treated or prevented with various methods, including pharmacological therapies. Anger or hostility may also be a risk or triggering factor for stroke, which highlights the importance of strategic management of anger for improving the patient's quality of life and preventing stroke occurrence.
Review
Plant Sciences
T. L. Olatunji, F. Siebert, A. E. Adetunji, B. H. Harvey, J. Gericke, J. H. Hamman, F. Van der Kooy
Summary: Sceletium tortuosum, a succulent forb endemic to South Africa, has been traditionally used for various medicinal purposes like pain relief, mood elevation, and cognitive enhancement. Recent research on this plant has revealed its potential in treating anxiety, depression, and enhancing cognitive functions through its bioactive alkaloids and extracts.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Health Care Sciences & Services
Bianca Codrina Morarasu, Adorata Elena Coman, Cristina Bologa, Catalina Lionte, Ovidiu Rusalim Petris, Alexandr Ceasovschih, Victorita Sorodoc, Raluca Ecaterina Haliga, Gabriela Puha, Alexandra Stoica, Oana Sirbu, Mihai Constantin, Laurentiu Sorodoc
Summary: Serotonin syndrome is a clinical toxidrome characterized by increased serotonin levels in the central nervous system. It can occur due to drug overdose, dose increase, or interaction between serotonergic agents. Diagnosis relies on patient history and clinical examination. Treatment involves supportive measures, discontinuation of the offending agent, and certain therapeutic agents.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Nutrition & Dietetics
Lucia Manfredi, Alessandra Accoto, Alessandro Couyoumdjian, David Conversi
Summary: This systematic review focuses on the genetic polymorphisms related to binge eating disorder (BED), highlighting potentially useful polymorphisms such as 5-HTTLPR, Taq1A, A118G, C957T, rs2283265, Val158Met, rs6198, Val103Ile, Ile251Leu, rs6265, and Leu72Met. Among these, Taq1A showed the most significant association with BED according to the research. Additional evidence is needed to confirm the impact of the other polymorphisms.
Review
Agriculture, Dairy & Animal Science
M. K. Connelly, A. A. Cheng, L. L. Hernandez
Summary: The peripartum period in dairy cows involves dynamic shifts in metabolic, mineral, and immune metabolism, with a focus on understanding the significant changes in calcium metabolism. Research has also explored the role of serotonin during the transition period and lactation, as well as its relationship with calcium. The review discusses recent advancements in calcium metabolism, mammary calcium transport, serotonin metabolism, and the serotonin-calcium axis, while acknowledging the challenges and limitations in current research on this topic.
JOURNAL OF DAIRY SCIENCE
(2021)
