Article
Urology & Nephrology
Nuria Lloberas, Josep M. Grinyo, Helena Colom, Anna Vidal-Alabro, Pere Fontova, Raul Rigo-Bonnin, Ariadna Padro, Oriol Bestard, Edoardo Melilli, Nuria Montero, Ana Coloma, Anna Manonelles, Maria Meneghini, Alex Fava, Joan Torras, Josep M. Cruzado
Summary: This study developed and validated a population pharmacokinetic model for tacrolimus dosing, which was found to be superior to traditional labeling-based dosing in achieving therapeutic targets. The model showed faster attainment of therapeutic levels and reduced dosage adjustments compared to the standard approach.
KIDNEY INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Pere Fontova, Helena Colom, Raul Rigo-Bonnin, Lisanne N. van Merendonk, Anna Vidal-Alabro, Nuria Montero, Edoardo Melilli, Maria Meneghini, Anna Manonelles, Josep M. Cruzado, Juan Torras, Josep Maria Grinyo, Oriol Bestard, Nuria Lloberas
Summary: The study compared the pharmacokinetic and pharmacodynamic profiles of tacrolimus between morning and night doses, showing significantly lower drug concentrations in whole blood and intracellular compartments after the night dose compared to the morning dose. However, this lower exposure did not translate into a significant reduction in pharmacodynamic effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Surgery
Klemens Budde, Lionel Rostaing, Umberto Maggiore, Giovanni Piotti, Daniela Surace, Silvia Geraci, Claudio Procaccianti, Gabriele Nicolini, Oliver Witzke, Nassim Kamar, Laetitia Albano, Matthias Buchler, Julio Pascual, Alex Gutierrez-Dalmau, Dirk Kuypers, Thomas Wekerle, Maciej Glyda, Mario Carmellini, Giuseppe Tisone, Karsten Midtvedt, Lars Wennberg, Josep M. Grinyo
Summary: The once-daily tacrolimus formulation, LCPT, achieves similar clinical outcomes to other tacrolimus formulations with a lower daily dose.
TRANSPLANT INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Maaike R. Schagen, Asiye Nur Ulu, Marith I. Francke, Jacqueline van de Wetering, Marleen C. van Buren, Sam Schoenmakers, Maja Matic, Ron H. N. van Schaik, Dennis A. Hesselink, Brenda C. M. de Winter
Summary: This study investigated the pharmacokinetics of tacrolimus during pregnancy and found that clearance of tacrolimus increases during pregnancy, resulting in decreased exposure to the drug. To maintain the therapeutic effect, the dose of tacrolimus needs to be increased during pregnancy.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Pere Fontova, Lisanne N. van Merendonk, Anna Vidal-Alabro, Raul Rigo-Bonnin, Gema Cerezo, Stefaan van Oevelen, Oriol Bestard, Edoardo Melilli, Nuria Montero, Ana Coloma, Anna Manonelles, Joan Torras, Josep M. Cruzado, Josep M. Grinyo, Helena Colom, Nuria Lloberas
Summary: Despite monitoring whole blood tacrolimus concentrations, acute rejection can still occur during tacrolimus therapy after kidney transplantation. This study aimed to investigate the intracellular pharmacokinetics (PK) of two tacrolimus formulations (immediate-release and extended-release) and their correlation with whole blood PK and pharmacodynamics (PD).
Review
Pharmacology & Pharmacy
Da-Hoon Lee, Hana Lee, Ha-Young Yoon, Jeong Yee, Hye-Sun Gwak
Summary: There is a correlation between the POR*28 genotype and the pharmacokinetics of TAC in early post-transplantation period in adult renal transplant recipients. Recipients with the POR*28 allele have lower standardized trough concentrations of TAC.
Article
Pharmacology & Pharmacy
M. I. Francke, W. J. Visser, D. Severs, A. M. E. de Mik-van Egmond, D. A. Hesselink, B. C. M. De Winter
Summary: This study investigated the relationship between tacrolimus pharmacokinetics and body composition parameters, and found that the phase angle was positively correlated with tacrolimus clearance. Incorporating the phase angle into a popPK model can improve the prediction of an individual's tacrolimus dose requirement after transplantation.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Thomas D. Nguyen, Nicholas M. Smith, Kris Attwood, Aijaz Gundroo, Shirley Chang, Mahfuz Yonis, Brian Murray, Kathleen M. Tornatore
Summary: This study compared the tacrolimus AUC(0-12) obtained by Non-Compartmental Analysis (NCA) with the Maximum a Posteriori-Bayesian (MAP-Bayesian) estimates from robust and sparse sampling in stable kidney transplant recipients. The results showed that the MAP-Bayesian estimation using sparse, two-specimen sampling is comparable to NCA and may enhance tacrolimus therapeutic drug monitoring (TDM) in stable kidney transplant recipients. Rating: 8/10.
Article
Pharmacology & Pharmacy
Jinhua Wen, Menghua ChenYang, Menghua Zhao, Weiqiang Hu, Yu Wei Xiao
Summary: The objective of this study was to investigate the effect of clarithromycin on the pharmacokinetics of tacrolimus in rats and better understand its mechanism. The results showed that clarithromycin increased the blood concentration of tacrolimus and affected its pharmacokinetic properties in rats.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Immunology
Violetta Dziedziejko, Krzysztof Safranow, Miros lawa Kijko-Nowak, Damian Malinowski, Leszek Domanski, Andrzej Pawlik
Summary: This study examined the association between leptin receptor gene polymorphisms and the development of post-transplant diabetes mellitus (PTDM) in patients treated with tacrolimus after kidney transplantation. The results found that patients with the LEPR gene rs1137101 G allele may have an increased risk of PTDM development.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medical Laboratory Technology
Marith Francke, Louise M. Andrews, Hoang Lan Le, Daan van de Velde, Marjolein Dieterich, Suwasin Udomkarnjananun, Marian C. Clahsen-van Groningen, Carla C. Baan, Teun van Gelder, Brenda C. M. de Winter, Dennis A. Hesselink
Summary: In the early phase after kidney transplantation, the exposure and distribution of tacrolimus appear stable. The tacrolimus concentration within peripheral blood mononuclear cells does not have a significant association with the occurrence of rejection.
CLINICAL BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Yi-Chang Zhao, Chen-Lin Xiao, Jing-Jing Hou, Jia-Kai Li, Bi-Kui Zhang, Xu-Biao Xie, Chun-Hua Fang, Feng-Hua Peng, Indy Sandaradura, Miao Yan
Summary: Tacrolimus exposure significantly increases during voriconazole co-therapy, with a highly variable magnitude that is difficult to predict quantitatively. Voriconazole is found to be the main factor causing variability in tacrolimus exposure, and the intensity of this effect is quantitative based on voriconazole concentration.
Article
Pharmacology & Pharmacy
Janaina B. F. Everton, Fernando J. B. Patricio, Manuel S. Faria, Teresa C. A. Ferreira, Elen A. Romao, Gyl E. B. Silva, Marcelo Magalhaes
Summary: Genetic polymorphisms in CYP3A5 and PPARA genes were found to be associated with the metabolism of tacrolimus in Brazilian kidney transplant recipients. These genetic variants may impact the individualized prescription of TAC in this population.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maaike R. Schagen, Helena Volarevic, Marith I. Francke, Sebastiaan D. T. Sassen, Marlies E. J. Reinders, Dennis A. Hesselink, Brenda C. M. de Winter
Summary: Tacrolimus is a potent immunosuppressive drug with many side effects. Therapeutic drug monitoring is performed to limit its toxicity, but the variability in its pharmacokinetics complicates its clinical management. Dosing algorithms have been developed to minimize exposure to off-target concentrations, but further evaluation is needed.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Amedeo De Nicolo, Michele Pinon, Alice Palermiti, Antonello Nonnato, Alessandra Manca, Jacopo Mula, Silvia Catalano, Francesco Tandoi, Renato Romagnoli, Antonio D'Avolio, Pier Luigi Calvo
Summary: The study aimed to describe the concentrations and variability of tacrolimus in whole blood and peripheral blood mononuclear cells (PBMC) in pediatric patients undergoing constant immunosuppressive maintenance therapy after liver transplantation. Variability in PBMC concentrations of tacrolimus was similar to the variability in whole blood, with weight-adjusted dose and age appearing as significant predictors of concentrations in both compartments. Seasonal variation of tacrolimus concentrations was observed in whole blood but not in PBMC within the same individual patients.
FRONTIERS IN PHARMACOLOGY
(2021)