Article
Agriculture, Dairy & Animal Science
Enoch B. de S. Jr Jr Meira, Emily E. Wiloch, Emma Nixon, James L. Yeatts, Farha Ferdous Sheela, Geof W. Smith, Ronald E. Baynes
Summary: The study evaluated the pharmacokinetics of transdermal flunixin in dairy goats and established milk withdrawal intervals of 60 hours and 96 hours to prevent residue contamination in the food supply.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Sanna M. Makela, Sofia D. Forssten, Marita Kailajarvi, Ville L. Langen, Mika Scheinin, Kirsti Tiihonen, Arthur C. Ouwehand
Summary: The study aimed to evaluate whether oral administration of probiotic B420 can attenuate the increase of calprotectin excretion induced by diclofenac sustained-release tablets. The results showed that short-term administration of B420 did not protect healthy adult participants from diclofenac-induced gastrointestinal inflammation.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Environmental Sciences
Xiangju Li, Xue Xue, Jia Jia, Xiaocui Zou, Yongjing Guan, Long Zhu, Zaizhao Wang
Summary: The overuse of antimicrobial agents is a key factor in the emergence of antibiotic resistance bacteria (ARB), but it is unclear whether non-antibiotic chemicals like nonsteroidal anti-inflammatory drug (NSAID) can induce ARB. This study investigated whether NSAID diclofenac (DCF) promotes the emergence of antibiotic resistance in Escherichia coli K12 MG1655. The results showed that DCF induced hereditary stable ARB and caused gene variation on the chromosome. DCF also triggered bacterial oxidative stress and SOS response, leading to enhanced expression of antioxidant and SOS system-related genes. However, high-dosage DCF reduced mutation frequency but enhanced mutant resistance.
ENVIRONMENTAL POLLUTION
(2023)
Article
Pharmacology & Pharmacy
Bangtao Yao, Fei Wang, Xiaogui Zhao, Bei Wang, Xiaoli Yue, Yuhua Ding, Gang Liu
Summary: The study found that topical application of 0.1% pranoprofen effectively reduces the expression of VEGF and COX-2 in primary pterygium, showing potential in prevention of postoperative recurrence for patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Brooklyn K. Wagner, Emma Nixon, Ivelisse Robles, Ronald E. Baynes, Johann F. Coetzee, Monique D. Pairis-Garcia
Summary: Castration and disbudding procedures in cattle are recognized as painful, with frequent lack of pain mitigation in the U.S. Non-steroidal anti-inflammatory drugs are commonly used in food-animal production systems, but are not federally approved for controlling procedural pain in cattle in the U.S. Further research is needed to address the variability in pain assessment methodologies and lack of validated approaches for assessing pain in cattle during routine management practices.
Review
Biochemistry & Molecular Biology
Ana Rita da Silva Ferreira, Anne-Grete Martson, Alyse de Boer, Hannah R. Wardill, Jan-Willem Alffenaar, Hermie J. M. Harmsen, Wim J. E. Tissing
Summary: Chemotherapy leads to decreased mucosal surface area, affecting drug transport across barrier. Key factors in drug absorption include gut microbiota, intestinal luminal pH, motility, and diet. Longitudinal studies and tools development are essential to design strategies to reduce severity and impact of GI-M in cancer patients.
Article
Food Science & Technology
Guohua Zhang, Xianghui Yan, Jiaheng Xia, Zhihong Zhang, Dongsheng Wang, Ping Sheng, Ping Yu, Zheling Zeng
Summary: This study aimed to investigate the anti-inflammatory activity of ethanol extracts (EE) of C. camphora seed and the changes after digestion and hydrolysis. The results showed that EE, digested ethanol extracts (dEE), and hydrolysed ethanol extracts (hEE) exhibited cell protection function and significantly reduced pro-inflammatory mediators and cytokines secretion and expression. Although the anti-inflammatory activity of EE was decreased, most of it was retained after digestion and hydrolysis. The findings suggest that the anti-inflammatory activity of EE is relatively stable and may facilitate the processing and consumption of related products.
Article
Cardiac & Cardiovascular Systems
Anders Holt, Jarl E. Strange, Nina Nouhravesh, Sebastian Kinnberg Nielsen, Mariam Elmegaard Malik, Anne -Marie Schjerning, Lars Kober, Christian Torp-Pedersen, Gunnar H. Gislason, Patricia McGettigan, Morten Schou, Morten Lamberts
Summary: This study found an association between short-term use of NSAIDs and an increased risk of first-time hospitalization for heart failure in patients with type 2 diabetes. Patients in subgroups with advanced age, elevated HbA1c levels, and new users of NSAIDs were particularly susceptible.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Allergy
Lily Li, Jillian Bensko, Kathleen Buchheit, Rebecca R. Saff, Tanya M. Laidlaw
Summary: This study investigated the safety and outcomes of two-step outpatient NSAID challenges for patients with non-aspirin-exacerbated respiratory disease (AERD)-related NSAID hypersensitivity. The results showed that more than 85% of the challenges were negative, allowing patients to use clinically indicated NSAIDs. The challenge reactions were generally mild.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Pharmacology & Pharmacy
Els Mehuys, Tine De Backer, Filip De Keyser, Thierry Christiaens, Thierry Van Hees, Sophie Demarche, Inge Van Tongelen, Koen Boussery
Summary: The concomitant use of NSAIDs and antithrombotic agents increases the risk of bleeding and thromboembolism. In this intervention study, community pharmacists screened for and managed interactions between these drugs. The results showed that most interactions did not result in a change of pharmacotherapy, but in some cases, changes in medication were made.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Barbara Hutka, Anett Varallyay, Szilvia B. Laszlo, Andras S. Toth, Balint Scheich, Sandor Paku, Imre Voros, Zoltan Pos, Zoltan V. Varga, Derek D. Norman, Andrea Balogh, Zoltan Benyo, Gabor Tigyi, Klara Gyires, Zoltan S. Zadori
Summary: Lysophosphatidic acid (LPA) plays an important role in both NSAID-induced gastric injury and small intestinal injury. The signaling pathway of LPAR2 receptor is involved in the development of small intestinal injury, as well as the inflammatory responses associated with ulceration.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Orthopedics
Andrew N. Fleischman, William T. Li, Andrew J. Luzzi, Duncan S. Van Nest, Marc C. Torjman, Eric S. Schwenk, William A. Arnold, Javad Parvizi
Summary: This study aimed to investigate whether extended NSAIDs after joint arthroplasty is associated with increased risk of gastrointestinal bleeding. Results showed that there was no positive association between NSAID use and gastrointestinal bleeding within 90 days postoperatively. Gastrointestinal bleeding was associated with anticoagulants, antiplatelet agents, and history of peptic ulcers.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Biochemistry & Molecular Biology
Dabin Jeong, Wan-Kyu Ko, Seong-Jun Kim, Gong-Ho Han, Daye Lee, Seung-Hun Sheen, Seil Sohn
Summary: LOBE significantly reduces NO production and pro-inflammatory gene expression in LPS-induced BMDMs, potentially through inhibition of the MAPK signaling pathway by reducing phosphorylation levels of ERK and JNK.
Article
Chemistry, Analytical
Ruijuan Zheng, Yingchen Yang, Chang Yang, Yan Xia
Summary: A core-shell material (UiO@TapbTp) has been developed for detecting nonsteroidal anti-inflammatory drugs by MALDI-TOF MS, showing improved enrichment ability and matrix performance. Pre-enrichment under optimized conditions significantly reduces the detection limits of drugs, with good recoveries in complex samples like saliva and environmental water.
Review
Peripheral Vascular Disease
J. David Spence, Tilo Grosser, Garret A. FitzGerald
Summary: Recent studies have questioned the safety of using acetaminophen for pain relief and fever reduction in patients with cardiovascular disease and those taking anticoagulants. The studies suggest that acetaminophen, like most nonsteroidal anti-inflammatory drugs, can increase blood pressure and formulations containing sodium can increase cardiovascular risk. The influence of acetaminophen on coagulation through its effects on vitamin K metabolism is also discussed.